التفاصيل البيبلوغرافية
| العنوان: |
Renal damage in patients with Type 2 diabetes: a strong predictor of mortality. |
| المؤلفون: |
Bo, S., Ciccone, G., Rosato, R., Gancia, R., Grassi, G., Merletti, F., Pagano, G. F. |
| المصدر: |
Diabetic Medicine; Mar2005, Vol. 22 Issue 3, p258-265, 8p |
| مصطلحات موضوعية: |
DEATH rate, PEOPLE with diabetes, DISEASES, KIDNEY diseases, CANCER patients, CARDIOVASCULAR diseases, DIABETES, CORONARY disease, ETIOLOGY of diseases |
| مستخلص: |
(i) To compare mortality rates in a cohort of Type 2 diabetic patients with those of the general population; (ii) to assess the prognostic role of pre-existing chronic conditions; (iii) to evaluate the impact of different severity of renal damage on mortality.All 3892 patients with Type 2 diabetes attending our Diabetic Clinic during 1995 and alive on 1 January 1996 were identified and followed for 4.5 years. Information on vital status (100% complete) and causes of death (98.5% complete) for 599 deceased subjects was derived from death certificates.In comparison with the general population, standardized mortality ratios (× 100) were: 125 (95% confidence interval 104–148) in patients aged< 75 and 85 (75–95) in patients≥ 75 years. Cardiovascular diseases and diabetes were responsible for most of the excess deaths. In a Cox-proportional hazard model, renal damage was a powerful predictor of death (hazard ratio = 2.39; 95% confidence intervals = 2.00–2.85). The severity of renal damage was associated with increasing hazard ratios for death from all-cause mortality and from specific causes (especially coronary artery disease, other cardiovascular causes and diabetes) after multiple adjustments. Other significant predictors of death were: greater age, glycated haemoglobin, smoking, lower body mass index, pre-existing coronary and peripheral artery disease and known co-morbidity (cirrhosis and cancer).Renal damage of any severity is significantly associated with subsequent mortality from all causes and from cardiovascular diseases. These associations are not confounded by pre-existing co-morbidity or coronary diseases.Diabet. Med. (2004) [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
