التفاصيل البيبلوغرافية
| العنوان: |
Epstein-Barr virus and methotrexate-related CNS lymphoma in a patient with rheumatoid arthritis. |
| المؤلفون: |
Migita, Kiyoshi, Miyashita, Taiichiro, Mijin, Toma, Sakito, Sohko, Kurohama, Hirokazu, Ito, Masahiro, Toda, Keisuke, Tsustumi, Keisuke, Baba, Hiroshi, Izumi, Yasumori, Kawakami, Atsushi, Niino, Daisuke, Ohshima, Kouichi |
| المصدر: |
Modern Rheumatology; Jul2013, Vol. 23 Issue 4, p832-836, 5p |
| مصطلحات موضوعية: |
EPSTEIN-Barr virus diseases, METHOTREXATE, CENTRAL nervous system cancer, LYMPHOMAS, RHEUMATOID arthritis treatment, LYMPHOPROLIFERATIVE disorders, TUMOR markers, DISEASE risk factors |
| مستخلص: |
Patients with rheumatoid arthritis (RA), especially those treated with methotrexate (MTX), might have an increased risk of lymphoproliferative disorders that are associated with Epstein-Barr virus (EBV). We describe a case of EBV-associated central nervous system (CNS) lymphoma (diffuse large B-cell lymphoma) in a patient with RA on a short course of MTX treatment. The neoplastic cells express the B-cell surface markers (CD20, Pax-5 and CD30), and EBV-encoded RNA was demonstrated by in situ hybridization. The patient's lymphoma did not recur for the 8-year follow-up period after the tumor resection and cessation of MTX. MTX may promote EBV-positive CNS lymphoma in RA patient due to its immunosuppressive properties as well as reactivating latent EBV infection. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
