دورية أكاديمية
Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series
| العنوان: | Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series |
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| المؤلفون: | Galvan, Antonella, Colombo, Francesca, Frullanti, Elisa, Dassano, Alice, Noci, Sara, Wang, Yufei, Eisen, Timothy, Matakidou, Athena, Dugo, Matteo, Ambrogi, Federico, Iacobucci, Ilaria, Incarbone, Matteo, Alloisio, Marco, Nosotti, Mario, Tosi, Davide, Santambrogio, Luigi, Pastorino, Ugo, Houlston, Richard S, Dragani, Tommaso A., Tomasello, Luisa, VEZZALINI, Marzia, SORIO, Claudio, MARTINELLI, Giovanni, Pelosi, Giuseppe |
| المساهمون: | Galvan, Antonella, Colombo, Francesca, Frullanti, Elisa, Dassano, Alice, Noci, Sara, Wang, Yufei, Eisen, Timothy, Matakidou, Athena, Tomasello, Luisa, Vezzalini, Marzia, Sorio, Claudio, Dugo, Matteo, Ambrogi, Federico, Iacobucci, Ilaria, Martinelli, Giovanni, Incarbone, Matteo, Alloisio, Marco, Nosotti, Mario, Tosi, Davide, Santambrogio, Luigi, Pelosi, Giuseppe, Pastorino, Ugo, Houlston, Richard S, Dragani, Tommaso A. |
| سنة النشر: | 2015 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | PTPRG, clinical stage, clonogenicity, genome-wide association, prognostic marker, tumor progression, Adenocarcinoma, Biomarkers, Tumor, European Continental Ancestry Group, Follow-Up Studie, Genetic Predisposition to Disease, Germ-Line Mutation, Human, Lung Neoplasm, Neoplasm Staging, Polymorphism, Single Nucleotide, Prognosi, Receptor-Like Protein Tyrosine Phosphatases, Class 5, Survival Rate, Validation Studies as Topic, Genome-Wide Association Study |
| الوصف: | In lung cancer, the survival of patients with the same clinical stage varies widely for unknown reasons. In this two-phase study, we examined the hypothesis that germline variations influence the survival of patients with lung adenocarcinoma. First, we analyzed existing genotype and clinical data from 289 UK-resident patients with lung adenocarcinoma, identifying 86 single nucleotide polymorphisms (SNPs) that associated with survival (p < 0.01). We then genotyped these candidate SNPs in a validation series of 748 patients from Italy that resulted genetically compatible with the UK series based on principal component analysis. In a Cox proportional hazard model adjusted for age, sex and clinical stage, four SNPs were confirmed on the basis of their having a hazard ratio (HR) indicating the same direction of effect in the two series and p < 0.05. The strongest association was provided by rs2107561, an intronic SNP of PTPRG, protein tyrosine phosphatase, receptor type, G; the C allele was associated with poorer survival in both patient series (pooled analysis loge HR = 0.31; 95% CI: 0.15-0.46, p = 8.5 × 10(-5) ). PTPRG mRNA levels in 43 samples of lung adenocarcinoma were 40% of those observed in noninvolved lung tissue from the same patients. PTPRG overexpression significantly inhibited the clonogenicity of A549 lung carcinoma cells and the anchorage-independent growth of the NCI-H460 large cell lung cancer line. These four germline variants represent promising candidates that, with further study, may help predict clinical outcome. In addition, the PTPRG locus may have a role in tumor progression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/25196286; info:eu-repo/semantics/altIdentifier/wos/WOS:000346350500006; volume:136; issue:5; firstpage:E262-71; lastpage:E271; numberofpages:9; journal:INTERNATIONAL JOURNAL OF CANCER; http://hdl.handle.net/11562/950121Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84918561286 |
| DOI: | 10.1002/ijc.29195 |
| الإتاحة: | https://doi.org/10.1002/ijc.29195Test http://hdl.handle.net/11562/950121Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.36A13941 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ijc.29195 |
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