التفاصيل البيبلوغرافية
العنوان:
The evolution of non-small cell lung cancer metastases in TRACERx
المؤلفون:
Al Bakir, Maise , Huebner, Ariana , Martinez-Ruiz, Carlos , Grigoriadis, Kristiana , Watkins, Thomas BK , Pich, Oriol , Moore, David A , Veeriah, Selvaraju , Ward, Sophia , Laycock, Joanne , Johnson, Diana , Rowan, Andrew , Razaq, Maryam , Akther, Mita , Naceur-Lombardelli, Cristina , Prymas, Paulina , Toncheva, Antonia , Hessey, Sonya , Dietzen, Michelle , Colliver, Emma , Frankell, Alexander , Bunkum, Abigail , Lim, Emilia L , Karasaki, Takahiro , Abbosh, Christopher , Hiley, Crispin T , Hill, Mark S , Cook, Daniel E , Wilson, Gareth A , Salgado, Roberto , Nye, Emma , Stone, Richard Kevin , Fennell, Dean A , Price, Gillian , Kerr, Keith M , Naidu, Babu , Middleton, Gary , Summers, Yvonne , Lindsay, Colin R , Blackhall, Fiona H , Cave, Judith , Blyth, Kevin G , Nair, Arjun , Ahmed, Asia , Taylor, Magali N , Procter, Alexander James , Falzon, Mary , Lawrence, David , Navani, Neal , Thakrar, Ricky M , Janes, Sam M , Papadatos-Pastos, Dionysis , Forster, Martin D , Lee, Siow Ming , Ahmad, Tanya , Quezada, Sergio , Peggs, Karl S , Van Loo, Peter , Dive, Caroline , Hackshaw, Allan , Birkbak, Nicolai J , Zaccaria, Simone , Jamal-Hanjani, Mariam , McGranahan, Nicholas , Swanton, Charles , Lester, Jason F , Bajaj, Amrita , Nakas, Apostolos , Sodha-Ramdeen, Azmina , Ang, Keng , Tufail, Mohamad , Chowdhry, Mohammed Fiyaz , Scotland, Molly , Boyles, Rebecca , Rathinam, Sridhar , Wilson, Claire , Marrone, Domenic , Dulloo, Sean , Matharu, Gurdeep , Shaw, Jacqui A , Riley, Joan , Primrose, Lindsay , Boleti, Ekaterini , Cheyne, Heather , Khalil, Mohammed , Richardson, Shirley , Cruickshank, Tracey , Benafif, Sarah , Gilbert, Kayleigh , Patel, Akshay J , Osman, Aya , Lacson, Christer , Langman, Gerald , Shackleford, Helen , Djearaman, Madava , Kadiri, Salma , Leek, Angela , Hodgkinson, Jack Davies , Totten, Nicola , Montero, Angeles , Smith, Elaine , Fontaine, Eustace , Granato, Felice , Doran, Helen , Novasio, Juliette , Rammohan, Kendadai , Joseph, Leena , Bishop, Paul , Shah, Rajesh , Moss, Stuart , Joshi, Vijay , Crosbie, Philip , Gomes, Fabio , Brown, Kate , Carter, Mathew , Chaturvedi, Anshuman , Priest, Lynsey , Oliveira, Pedro , Krebs, Matthew G , Clipson, Alexandra , Tugwood, Jonathan , Kerr, Alastair , Rothwell, Dominic G , Kilgour, Elaine , Aerts, Hugo JWL , Schwarz, Roland F , Kaufmann, Tom L , Rosenthal, Rachel , Szallasi, Zoltan , Kisistok, Judit , Sokac, Mateo , Diossy, Miklos , Demeulemeester, Jonas , Stewart, Aengus , Magness, Alastair , Karamani, Angeliki , Chain, Benny , Campbell, Brittany B , Castignani, Carla , Bailey, Chris , Puttick, Clare , Weeden, Clare E , Lee, Claudia , Richard, Corentin , Pearce, David R , Karagianni, Despoina , Biswas, Dhruva , Levi, Dina , Hoxha, Elena , Larose Cadieux, Elizabeth , Gronroos, Eva , Galvez-Cancino, Felip , Athanasopoulou, Foteini , Gimeno-Valiente, Francisco , Kassiotis, George , Stavrou, Georgia , Mastrokalos, Gerasimos , Zhai, Haoran , Lowe, Helen L , Matos, Ignacio , Goldman, Jacki , Reading, James L , Black, James RM , Herrero, Javier , Rane, Jayant K , Nicod, Jerome , Lam, Jie Min , Hartley, John A , Enfield, Katey SS , Selvaraju, Kayalvizhi , Thol, Kerstin , Litchfield, Kevin , Ng, Kevin W , Chen, Kezhong , Dijkstra, Krijn , Thakkar, Krupa , Ensell, Leah , Shah, Mansi , Vasquez, Marcos , Litovchenko, Maria , Werner Sunderland, Mariana , Leung, Michelle , Escudero, Mickael , Angelova, Mihaela , Tanic, Miljana , Sivakumar, Monica , Kanu, Nnennaya , Chervova, Olga , Lucas, Olivia , Al-Sawaf, Othman , Hobson, Philip , Pawlik, Piotr , Bentham, Robert , Hynds, Robert E , Vendramin, Roberto , Saghafinia, Sadegh , Lopez, Saioa , Gamble, Samuel , Ung, Seng Kuong Anakin , Vanloo, Sharon , Boeing, Stefan , Beck, Stephan , Bola, Supreet Kaur , Denner, Tamara , Marafioti, Teresa , Mourikis, Thanos P , Spanswick, Victoria , Barbe, Vittorio , Lu, Wei-Ting , Hill, William , Liu, Wing Kin , Wu, Yin , Naito, Yutaka , Ramsden, Zoe , Veiga, Catarina , Royle, Gary , Collins-Fekete, Charles-Antoine , Fraioli, Francesco , Ashford, Paul , Clark, Tristan , Borg, Elaine , Wilson, James , Patrini, Davide , Martinoni Hoogenboom, Emilie , Monk, Fleur , Holding, James W , Choudhary, Junaid , Bhakhri, Kunal , Scarci, Marco , Hayward, Martin , Panagiotopoulos, Nikolaos , Gorman, Pat , Khiroya, Reena , Stephens, Robert CM , Wong, Yien Ning Sophia , Bandula, Steve , Sharp, Abigail , Smith, Sean , Gower, Nicole , Dhanda, Harjot Kaur , Chan, Kitty , Pilotti, Camilla , Leslie, Rachel , Grapa, Anca , Zhang, Hanyun , AbdulJabbar, Khalid , Pan, Xiaoxi , Yuan, Yinyin , Chuter, David , MacKenzie, Mairead , Chee, Serena , Alzetani, Aiman , Scarlett, Lydia , Richards, Jennifer , Ingram, Papawadee , Austin, Silvia , Lim, Eric , De Sousa, Paulo , Jordan, Simon , Rice, Alexandra , Raubenheimer, Hilgardt , Bhayani, Harshil , Ambrose, Lyn , Devaraj, Anand , Chavan, Hema , Begum, Sofina , Buderi, Silviu , Kaniu, Daniel , Malima, Mpho , Booth, Sarah , Nicholson, Andrew G , Fernandes, Nadia , Shah, Pratibha , Proli, Chiara , Hewish, Madeleine , Danson, Sarah , Shackcloth, Michael J , Robinson, Lily , Russell, Peter , Dick, Craig , Le Quesne, John , Kirk, Alan , Asif, Mo , Bilancia, Rocco , Kostoulas, Nikos , Thomas, Mathew
بيانات النشر:
NATURE PORTFOLIO, 2023.
سنة النشر:
2023
مصطلحات موضوعية:
Clonal Evolution , Cohort Studies , Evolution, Molecular , Lung Neoplasms , Carcinoma, Non-Small-Cell Lung , Disease Progression , Humans , Neoplasm Metastasis , Neoplasm Recurrence, Local , Clone Cells
الوصف:
Metastatic disease is responsible for the majority of cancer-related deaths1. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited patients in TRACERx who developed metastatic disease, compared with a control cohort of 144 non-metastatic tumours. In 25% of cases, metastases diverged early, before the last clonal sweep in the primary tumour, and early divergence was enriched for patients who were smokers at the time of initial diagnosis. Simulations suggested that early metastatic divergence more frequently occurred at smaller tumour diameters (less than 8 mm). Single-region primary tumour sampling resulted in 83% of late divergence cases being misclassified as early, highlighting the importance of extensive primary tumour sampling. Polyclonal dissemination, which was associated with extrathoracic disease recurrence, was found in 32% of cases. Primary lymph node disease contributed to metastatic relapse in less than 20% of cases, representing a hallmark of metastatic potential rather than a route to subsequent recurrences/disease progression. Metastasis-seeding subclones exhibited subclonal expansions within primary tumours, probably reflecting positive selection. Our findings highlight the importance of selection in metastatic clone evolution within untreated primary tumours, the distinction between monoclonal versus polyclonal seeding in dictating site of recurrence, the limitations of current radiological screening approaches for early diverging tumours and the need to develop strategies to target metastasis-seeding subclones before relapse. ispartof: NATURE vol:616 issue:7957 ispartof: location:England status: Published online
وصف الملف:
Print-Electronic
اللغة:
English
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=od______1131::2ee2b4eed3d0189b1cb2ad1c2918165dTest https://lirias.kuleuven.be/handle/20.500.12942/721148Test
حقوق:
OPEN
رقم الانضمام:
edsair.od......1131..2ee2b4eed3d0189b1cb2ad1c2918165d
قاعدة البيانات:
OpenAIRE
