التفاصيل البيبلوغرافية
| العنوان: |
Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells. |
| المؤلفون: |
Lord, James D.1,2 jdlord@u.washington.edu, Hackman, Robert C.3,4, Moklebust, Amanda4, Thompson, John A.1,4, Higano, Celestia S.1, Chielens, Deborah, Steinbach, Gideon1, McDonald, George B.1 |
| المصدر: |
Digestive Diseases & Sciences. May2010, Vol. 55 Issue 5, p1396-1405. 10p. 3 Color Photographs, 2 Charts, 1 Graph. |
| مصطلحات موضوعية: |
*COLITIS treatment, *THERAPEUTIC use of immunoglobulins, *T cells, *LYMPHOCYTES, *CANCER treatment, *IMMUNOSUPPRESSION, *OPPORTUNISTIC infections, *COLITIS diagnosis, *THERAPEUTIC use of monoclonal antibodies, *BIOPSY, *CLINICAL trials, *COLITIS, *COMPARATIVE studies, *CAUSES of death, *RESEARCH methodology, *MEDICAL cooperation, *MELANOMA, *MONOCLONAL antibodies, *PROSTATE tumors, *PROTEINS, *RESEARCH, *EVALUATION research, *TREATMENT effectiveness |
| مستخلص: |
Ipilimumab is a humanized antibody to CTLA4 and is used to treat cancers refractory to conventional treatment. We treated 21 patients with refractory melanoma or prostate cancer with anti-CTLA4 antibody (ipilimumab), with subsequent development of significant colitis in nine cases. Two of these nine did not respond rapidly to high-dose (2 mg kg(-1) day(-1)) glucocorticoids or infliximab. They required additional immunosuppression, and one ultimately died of opportunistic infection, representing a more refractory course than has previously been described complicating ipilimumab therapy. Both patients had received radiation to the pelvis for prostate cancer less than 1 year prior to receiving ipilimumab. We performed immunohistochemical analysis of colon biopsies from ipilimumab recipients to determine if colitis correlates with depletion of intramucosal FOXP3(+) regulatory T cells (Tregs), which normally express CTLA4. However, we found no evidence of FOXP3(+) T cell depletion in any of the nine patients who developed colitis. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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