التفاصيل البيبلوغرافية
| العنوان: |
A Randomized Clinical Trial Assessing Continuous Glucose Monitoring (CGM) Use With Standardized Education With or Without a Family Behavioral Intervention Compared With Fingerstick Blood Glucose Monitoring in Very Young Children With Type 1 Diabetes. |
| المؤلفون: |
Laffel, Lori, Harrington, Kara, Hanono, Anat, Naik, Nisha, Ambler-Osborn, Louise, Schultz, Alan, DiMeglio, Linda, Woerne, Stephanie, Jolivette, Heather, Ismail, Heba, Tebbe, Megan, Newman, America, Legge, Megan, Tamborlane, William, Van Name, Michelle, Weyman, Kate, Finnegan, Jennifer, Steffen, Amy, Zgorski, Melinda, DeSalvo, Daniel |
| المصدر: |
Diabetes Care; Feb2021, Vol. 44 Issue 2, p464-472, 9p |
| مصطلحات موضوعية: |
BLOOD sugar monitoring, TYPE 1 diabetes, CLINICAL trials, GLUCOSE, STEPFAMILIES |
| مستخلص: |
Objective: This study evaluated the effects of continuous glucose monitoring (CGM) combined with family behavioral intervention (CGM+FBI) and CGM alone (Standard-CGM) on glycemic outcomes and parental quality of life compared with blood glucose monitoring (BGM) in children ages 2 to <8 years with type 1 diabetes.Research Design and Methods: This was a multicenter (N = 14), 6-month, randomized controlled trial including 143 youth 2 to <8 years of age with type 1 diabetes. Primary analysis included treatment group comparisons of percent time in range (TIR) (70-180 mg/dL) across follow-up visits.Results: Approximately 90% of participants in the CGM groups used CGM ≥6 days/week at 6 months. Between-group TIR comparisons showed no significant changes: CGM+FBI vs. BGM 3.2% (95% CI -0.5, 7.0), Standard-CGM vs. BGM 0.5% (-2.6 to 3.6), CGM+FBI vs. Standard-CGM 2.7% (-0.6, 6.1). Mean time with glucose level <70 mg/dL was reduced from baseline to follow-up in the CGM+FBI (from 5.2% to 2.6%) and Standard-CGM (5.8% to 2.5%) groups, compared with 5.4% to 5.8% with BGM (CGM+FBI vs. BGM, P < 0.001, and Standard-CGM vs. BGM, P < 0.001). No severe hypoglycemic events occurred in the CGM+FBI group, one occurred in the Standard-CGM group, and five occurred in the BGM group. CGM+FBI parents reported greater reductions in diabetes burden and fear of hypoglycemia compared with Standard-CGM (P = 0.008 and 0.04) and BGM (P = 0.02 and 0.002).Conclusions: CGM used consistently over a 6-month period in young children with type 1 diabetes did not improve TIR but did significantly reduce time in hypoglycemia. The FBI benefited parental well-being. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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