دورية أكاديمية
Prognostic role of clinical and laboratory criteria to identify earlyventilator-associated pneumonia in brain injury.
| العنوان: | Prognostic role of clinical and laboratory criteria to identify earlyventilator-associated pneumonia in brain injury. |
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| المؤلفون: | PELOSI, PAOLO PASQUALINO, BARASSI A, SEVERGNINI P, GOMIERO B, FINAZZI S, MERLINI G, D'ERIL G. M, CHIARANDA M, NIEDERMAN M. S. |
| المساهمون: | Pelosi, PAOLO PASQUALINO, Barassi, A, Severgnini, P, Gomiero, B, Finazzi, S, Merlini, G, D'Eril, G. M., Chiaranda, M, Niederman, M. S. |
| بيانات النشر: | American College of Chest Physicians USA Northbrook |
| سنة النشر: | 2008 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | Clinical pulmonary infection score, Procalcitonin, C-reactive protein, Amyloid A, Ventilator-associated pneumonia |
| الوصف: | BACKGROUND: We investigated the role of the clinical pulmonary infection score (CPIS), serum levels of procalcitonin (PCT), C-reactive protein (CRP), and serum amyloid A (SAA) in the detection of patients with early ventilator-associated pneumonia (VAP). METHODS: Observational study in a university hospital. In 58 patients with severe brain injury receiving mechanical ventilation, CPIS, PCT, CRP and SAA were evaluated at ICU entry and at days 3 to 4 of hospital stay for VAP diagnosis (confirmed by endotracheal aspirate or BAL cultures). RESULTS: We found the following: (1) PCT at entry was increased in patients who later had early VAP develop (25 patients) compared to no VAP (median, 1.4 ng/mL; 25-75 percentiles, 0.14-0.78; vs median, 0.2 ng/mL; 25-75 percentiles, 0.76-2.4, p<0.001; sensitivity, 76%; and specificity, 75%); (2) CPIS increased at the day of VAP diagnosis, compared to entry (median, 6.6+/-1.1 vs 1.5+/-1.1, p<0.001; sensitivity, 97%; specificity, 100%), while other serum inflammatory markers did not change; and (3) deterioration in oxygenation and changes in tracheal secretions were the main determinants of CPIS changes. CONCLUSIONS: PCT may be a useful marker to predict which patients subsequently have early VAP. The CPIS could help as an early way to detect the patients with early VAP and who need further diagnostic testing. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000257850100018; volume:134(1); firstpage:101; lastpage:108; numberofpages:8; journal:CHEST; http://hdl.handle.net/11567/254874Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-47549084857 |
| DOI: | 10.1378/chest.07-2546 |
| الإتاحة: | https://doi.org/10.1378/chest.07-2546Test http://hdl.handle.net/11567/254874Test |
| رقم الانضمام: | edsbas.348EC9EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1378/chest.07-2546 |
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