التفاصيل البيبلوغرافية
| العنوان: |
Headache in idiopathic/genetic epilepsy: Cluster analysis in a large cohort |
| المؤلفون: |
Arife Çimen Atalar, Bengi Gül Türk, Esme Ekizoglu, Duygu Kurt Gök, Betül Baykan, Aynur Özge, Semih Ayta, Füsun Ferda Erdoğan, Seher Naz Yeni, Bahar Taşdelen, Sibel K. Velioglu, Zuhal Yapıcı, İpek Midi, Serap Saygı, Ulufer Çelebi, Elif Sarıca Darol, Kadriye Ağan, Senem Ayça, Sibel Gazioğlu, Zeynep Vildan Okudan, Nermin Görkem Şirin, Nerses Bebek, Neşe Dericioğlu, İlknur Güçlü Altun, Ayşe Destina Yalçın, Reyhan Sürmeli, Oğuz Osman Erdinç, Abidin Erdal, Demet İlhan Algın, Gülnihal Kutlu, Semai Bek, Yüksel Erdal, Akçay Övünç Özön, Aylin Reyhani, Babürhan Güldiken, Barış Baklan, Bülent Oğuz Genç, Ebru Aykutlu Altındağ, Gökçen Karahan, Güray Koç, Handan Mısırlı, İbrahim Öztura, Kezban Aslan‐Kara, Merve Melodi Çakar, Nur Türkmen, Onur Bulut, Ömer Karadaş, Özlem Kesim Şahin, Sevgi Ferik, Mehmet Taylan Peköz, Pınar Topaloğlu, Sibel Üstün Özek, Ülkühan Düzgün, Vildan Yayla, Yasemin Gömceli, Zeynep Ünlüsoy Acar |
| المساهمون: |
Atalar A. C., TÜRK B. G., Ekizoglu E., Gok D. K., BAYKAL B., ÖZGE A., Ayta S., ERDOĞAN F. F., YENİ S. N., Tasdelen B., et al. |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Adult, Adolescent, CHILDHOOD, UNITED-STATES, CHILDREN, idiopathic epilepsy, CLINICAL NEUROLOGY, Sağlık Bilimleri, Clinical Medicine (MED), CLASSIFICATION, MIGRALEPSY, MECHANISMS, Cohort Studies, Nöroloji, Seizures, Health Sciences, Cluster Analysis, Humans, Klinik Tıp (MED), JUVENILE MYOCLONIC EPILEPSY, Child, KLİNİK NÖROLOJİ, Internal Medicine Sciences, Klinik Tıp, headache phenotypes, Myoclonic Epilepsy, Juvenile, Headache, Life Sciences, Electroencephalography, Dahili Tıp Bilimleri, CLINICAL MEDICINE, Tıp, PREVALENCE, MIGRAINE, Neurology, Medicine, myoclonic seizures, Epilepsy, Generalized, genetic epilepsy, Neurology (clinical), BURDEN |
| الوصف: |
© 2022 International League Against Epilepsy.Objective: The link between headache and epilepsy is more prominent in patients with idiopathic/genetic epilepsy (I/GE). We aimed to investigate the prevalence of headache and to cluster patients with regard to their headache and epilepsy features. Methods: Patients aged 6–40 years, with a definite diagnosis of I/GE, were consecutively enrolled. The patients were interviewed using standardized epilepsy and headache questionnaires, and their headache characteristics were investigated by experts in headache. Demographic and clinical variables were analyzed, and patients were clustered according to their epilepsy and headache characteristics using an unsupervised K-means algorithm. Results: Among 809 patients, 508 (62.8%) reported having any type of headache; 87.4% had interictal headache, and 41.2% had migraine. Cluster analysis revealed two distinct groups for both adults and children/adolescents. In adults, subjects having a family history of headache, ≥5 headache attacks, duration of headache ≥ 24 months, headaches lasting ≥1 h, and visual analog scale scores > 5 were grouped in one cluster, and subjects with juvenile myoclonic epilepsy (JME), myoclonic seizures, and generalized tonic–clonic seizures (GTCS) were clustered in this group (Cluster 1). Self-limited epilepsy with centrotemporal spikes and epilepsy with GTCS alone were clustered in Cluster 2 with the opposite characteristics. For children/adolescents, the same features as in adult Cluster 1 were clustered in a separate group, except for the presence of JME syndrome and GTCS alone as a seizure type. Focal seizures were clustered in another group with the opposite characteristics. In the entire group, the model revealed an additional cluster, including patients with the syndrome of GTCS alone (50.51%), with ≥5 attacks, headache lasting >4 h, and throbbing headache; 65.66% of patients had a family history of headache in this third cluster (n = 99). Significance: Patients with I/GE can be clustered into distinct groups according to headache features along with seizures. Our findings may help in management and planning for future studies. |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a892a180123968b021327440ab719cc7Test
https://avesis.kayseri.edu.tr/publication/details/8ddb45db-24d3-4b0b-93b5-f84d77e58095/oaiTest |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....a892a180123968b021327440ab719cc7 |
| قاعدة البيانات: |
OpenAIRE |
