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1
المؤلفون: Stefania Ursu, Daqing Sun, Yosup Rew, Juan C. Jaen, Jay P. Powers, Xiao He, Hua Tu, Dustin McMinn, Michael DeGraffenreid
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3786-3790
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Transfection, Biochemistry, Piperazines, 11β hsd1 inhibitors, Structure-Activity Relationship, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Humans, Anilides, Enzyme Inhibitors, Piperazine, Molecular Biology, Biological evaluation, chemistry.chemical_classification, Sulfonamides, Aniline Compounds, Chemistry, Organic Chemistry, Combinatorial chemistry, Sulfonamide, Enzyme Activation, HEK293 Cells, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dba869c5b86ee839f3659912c3cf28cTest
https://doi.org/10.1016/j.bmcl.2012.04.005Test -
2
المؤلفون: Minqing Rong, Brian Lucas, Wendy Zhong, Guifen Xu, Gary Lee, Ben Jiang, Angela Chong, Qiuping Ye, Michael DeGraffenreid, Tom Huang, Dineli Wickramasinghe, Randall W. Hungate, Wade Aaron, Michael G. Johnson, Jessica Orf, Dustin McMinn, Matthew L. Brown, Richard J. Austin, Maria M. Toteva, Jacob Kaizerman, Jay P. Powers
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5206-5209
مصطلحات موضوعية: Molecular Structure, Drug discovery, Chemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, Pharmaceutical Science, Stereoisomerism, Amides, Biochemistry, Hedgehog signaling pathway, In vitro, High-Throughput Screening Assays, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Amide, Drug Discovery, Molecular Medicine, Structure–activity relationship, Enzyme Inhibitors, Smoothened, Molecular Biology, Acyltransferases
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04781a646e08a0a28c33cc60de02716aTest
https://doi.org/10.1016/j.bmcl.2011.07.052Test -
3
المؤلفون: Hua Tu, Lisa Julian, Nigel Walker, Maren Gulsrud Willcockson, Yosup Rew, Michael DeGraffenreid, Zhulun Wang, Juan C. Jaen, Daqing Sun, Ron C. Kelly, Athena Sudom, Seb Caille, Jacob Kaizerman, Jay P. Powers, Xuelei Yan, Qiuping Ye, Stefania Ursu, Ben Jiang, Felix Gonzalez-Lopez de Turiso, Randall W. Hungate, Dustin McMinn
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:405-410
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, 11β hsd1 inhibitors, Structure-Activity Relationship, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Organic Chemistry, Highly selective, Combinatorial chemistry, Rats, Macaca fascicularis, Enzyme, Enzyme inhibitor, Benzamides, Microsomes, Liver, biology.protein, Molecular Medicine, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d541a6a690483f033c76a34f9400098Test
https://doi.org/10.1016/j.bmcl.2010.10.129Test -
4
المؤلفون: Qiuping Ye, Daqing Sun, Jay P. Powers, Liang Tang, Craig Tomooka, Stefania Ursu, Hua Tu, Yongmei Di, Athena Sudom, Xuelei Yan, Juan C. Jaen, Shichang Miao, Nigel Walker, Ji Ma, Zhulun Wang, Marc Labelle
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3513-3516
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Nitro compound, Pharmaceutical Science, Dehydrogenase, Crystallography, X-Ray, Biochemistry, Isozyme, Chemical synthesis, Piperazines, Small Molecule Libraries, Mice, Structure-Activity Relationship, Oxidoreductase, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Animals, Humans, Sulfhydryl Compounds, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Chemistry, Organic Chemistry, Stereoisomerism, Molecular Weight, Enzyme, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feda87be89ed15aa5be09784f6a201c2Test
https://doi.org/10.1016/j.bmcl.2008.05.025Test -
5
المؤلفون: H. DiMaio, Xi Chen, Jay P. Powers, Lingming Liang, Matt Wright, C. Stein, M.G. Peterson, J. Adrian, V. Mayorga, F. Spector, D. Xu, Timothy D. Cushing, Juan C. Jaen, Shichang Miao, Qiuping Ye
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2188-2192
مصطلحات موضوعية: DNA Replication, Ganciclovir, Human cytomegalovirus, Drug-Related Side Effects and Adverse Reactions, viruses, Clinical Biochemistry, Administration, Oral, Biological Availability, Cytomegalovirus, Pharmaceutical Science, DNA Primase, Antiviral Agents, Biochemistry, Virus, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Cytotoxicity, Molecular Biology, Organic Chemistry, virus diseases, Viral Load, medicine.disease, Virology, In vitro, Rats, Pyrimidines, chemistry, Molecular Medicine, Primase, DNA, medicine.drug, Cidofovir
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162f4c78a289c611f72251a3cfad2530Test
https://doi.org/10.1016/j.bmcl.2007.01.109Test -
6
المؤلفون: Zhaodan Cao, Zhulun Wang, Xiong Gao, Shichang Miao, Nigel Walker, Daqing Sun, Jingqian Liu, Xuelei Yan, Juan C. Jaen, Jay P. Powers, Sheree Johnstone, Matt Wright, Sarah E. Lively, Craig Tomooka, Athena Sudom, Qiuping Ye
المصدر: Bioorganicmedicinal chemistry letters. 25(23)
مصطلحات موضوعية: Benzimidazole, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Plasma protein binding, Interleukin-1 receptor, Biochemistry, Enzyme activator, chemistry.chemical_compound, Structure-Activity Relationship, Interleukin-1 Receptor-Associated Kinases, Drug Discovery, Structure–activity relationship, Animals, Molecular Biology, Protein Kinase Inhibitors, Molecular Structure, Kinase, Drug discovery, Organic Chemistry, Rats, Enzyme Activation, chemistry, Molecular Medicine, Benzimidazoles, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd44dcd29b0a637c7841b3cba44835baTest
https://pubmed.ncbi.nlm.nih.gov/26526214Test -
7
المؤلفون: Juan C. Jaen, Jay P. Powers, Nigel Walker, Zhulun Wang, Holger Wesche, Jinqian Liu, Shyun Li
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:2842-2845
مصطلحات موضوعية: Alkylation, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Interleukin-1 receptor, Biochemistry, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Molecular Structure, biology, Kinase, Chemistry, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Amides, Small molecule, Cross-Linking Reagents, Interleukin-1 Receptor-Associated Kinases, Enzyme inhibitor, biology.protein, Cancer research, Molecular Medicine, Benzimidazoles, Signal transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafa1dfbff1d49a203522f7ff6c7cd8cTest
https://doi.org/10.1016/j.bmcl.2006.03.020Test -
8
المؤلفون: Pingchen Fan, Dustin McMinn, Shichang Miao, Jinsong Liu, Ji Ma, Liang Tang, Xuelei Yan, Marc Labelle, Athena Sudom, Stefania Ursu, Michael DeGraffenreid, Yongmei Di, Xiao He, Zhulun Wang, Juan C. Jaen, Jay P. Powers, Daqing Sun, Hua Tu, Nigel Walker, Mario G. Cardozo, Qiuping Ye
المصدر: Bioorganicmedicinal chemistry letters. 20(23)
مصطلحات موضوعية: education, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Structure-Activity Relationship, In vivo, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Structure–activity relationship, Animals, Humans, Pharmacokinetics, Sulfones, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Biological activity, humanities, In vitro, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daae63f2306af982135000129eb9d5f9Test
https://pubmed.ncbi.nlm.nih.gov/20971000Test -
9
المؤلفون: Randall W. Hungate, Brian Lucas, Hon Chan, Maria M. Toteva, Tom Huang, Dineli Wickramasinghe, Gary Lee, Minqing Rong, Matthew L. Brown, Ben Jiang, Dustin McMinn, Richard J. Austin, Songzhu An, Craig Uyeda, Jacob Kaizerman, Guifen Xu, Wade Aaron, Angela Chong, Qiuping Ye, Wendy Zhong, Jessica Orf, Jay P. Powers, Michael G. Johnson
المصدر: Bioorganicmedicinal chemistry letters. 20(12)
مصطلحات موضوعية: Patched, medicine.medical_specialty, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Biochemistry, Receptors, G-Protein-Coupled, Mice, Cytochrome P-450 Enzyme System, Internal medicine, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Hedgehog Proteins, Molecular Biology, Hedgehog, G protein-coupled receptor, Cell growth, Chemistry, Organic Chemistry, Smoothened Receptor, Hedgehog signaling pathway, Endocrinology, Drug Design, Cancer research, Molecular Medicine, Phthalazines, Signal transduction, Smoothened, Medulloblastoma, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d88f5beb31bc32720cc5c1c19dadd9Test
https://pubmed.ncbi.nlm.nih.gov/20493695Test -
10
المؤلفون: Qiuping Ye, Stefania Ursu, Jay P. Powers, Yosup Rew, Juan C. Jaen, Randall W. Hungate, Daqing Sun, Elisia Villemure, Dustin McMinn, Xuelei Yan, Hua Tu, Zhulun Wang, Athena Sudom, Nigel Walker, Xiao He
المصدر: Bioorganicmedicinal chemistry letters. 19(6)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, In vitro cytotoxicity, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Piperidines, In vivo, Microsomes, Drug Discovery, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Humans, Insulin, Benzamide, Molecular Biology, biology, Molecular Structure, Organic Chemistry, Insulin sensitivity, Metabolic stability, chemistry, Diabetes Mellitus, Type 2, Models, Chemical, Solubility, Enzyme inhibitor, Drug Design, Benzamides, biology.protein, Hepatocytes, Molecular Medicine, Selectivity
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37418dd9817f150928c58401b1067457Test
https://pubmed.ncbi.nlm.nih.gov/19217779Test