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المؤلفون: Mai H. Mekkawy, Albena T. Dinkova-Kostova, Mostafa M. Ghorab, Heba M. Karam, Aiten M. Soliman, Maureen Higgins
المصدر: Bioorganicmedicinal chemistry letters. 42
مصطلحات موضوعية: Antioxidant, Halogenation, NF-E2-Related Factor 2, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, 01 natural sciences, Biochemistry, Median lethal dose, Antioxidants, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Humans, Molecular Biology, Quinazolinones, chemistry.chemical_classification, Reactive oxygen species, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Malondialdehyde, KEAP1, Molecular biology, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Oxidative Stress, Molecular Medicine, Oxidative stress, Acetamide
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a02466f1c4857fb78d12859b05326d5Test
https://pubmed.ncbi.nlm.nih.gov/33811990Test -
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المؤلفون: Suqing Zheng, René V. Bensasson, Albena T. Dinkova-Kostova, Wei Li, Akira Saito, Vincent Zoete, Tadashi Honda
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4345-4349
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Electrons, Alkenes, 01 natural sciences, Biochemistry, Mice, 03 medical and health sciences, Cell Line, Tumor, Nitriles, Drug Discovery, NAD(P)H Dehydrogenase (Quinone), Animals, Potency, Reactivity (chemistry), Sulfhydryl Compounds, Enzyme inducer, Molecular Biology, HOMO/LUMO, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Molecular Structure, biology, Bicyclic molecule, 010405 organic chemistry, Chemistry, Organic Chemistry, Ketones, 0104 chemical sciences, 030104 developmental biology, Enzyme, Electron affinity (data page), Cyclization, Cytoprotection, Enzyme Induction, biology.protein, Quantum Theory, Molecular Medicine, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b72f814fedbc5f4e00f65a00584375eTest
https://doi.org/10.1016/j.bmcl.2016.07.028Test -
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المؤلفون: Emilie David, Chitra Sundararajan, Eric M. Padegimas, Albena T. Dinkova-Kostova, W. Christian Wigley, Melean Visnick, Tadashi Honda, Ron Bumeister
المصدر: Bioorganicmedicinal chemistry letters. 21(8)
مصطلحات موضوعية: Stereochemistry, medicine.drug_class, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Nitric Oxide, Biochemistry, Chemical synthesis, Anti-inflammatory, chemistry.chemical_compound, Interferon-gamma, Mice, Cell Line, Tumor, Drug Discovery, medicine, NAD(P)H Dehydrogenase (Quinone), Potency, Bioassay, Animals, Oleanolic Acid, Molecular Biology, Oleanolic acid, Chemistry, Organic Chemistry, Imidazoles, Biological activity, Cytoprotective Agent, In vitro, Cytoprotection, Molecular Medicine, Heme Oxygenase-1
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37e25ee20084c69fedc4c88ca8a4c85Test
https://pubmed.ncbi.nlm.nih.gov/21441026Test -
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المصدر: Chemistrybiology. 17(1)
مصطلحات موضوعية: Stereochemistry, NF-E2-Related Factor 2, Clinical Biochemistry, Catechols, medicine.disease_cause, Biochemistry, Cell Line, chemistry.chemical_compound, Catecholamines, Phenols, Genes, Reporter, Drug Discovery, medicine, Benzoquinones, Humans, Luciferase, Antioxidant Response Elements, Luciferases, Molecular Biology, Transcription factor, Pharmacology, A549 cell, Catechol, Kelch-Like ECH-Associated Protein 1, Chemistry, Intracellular Signaling Peptides and Proteins, Promoter, General Medicine, Glutathione, Hydroquinones, Oxygen, CHEMBIO, Gene Expression Regulation, SIGNALING, Electrophile, Molecular Medicine, Oxidation-Reduction, Oxidative stress, Copper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4799c0a7deba539c7f4ec44bcb4e9352Test
https://pubmed.ncbi.nlm.nih.gov/20142043Test -
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المصدر: BioFactors (Oxford, England). 35(2)
مصطلحات موضوعية: and the sirtuin protein systems. Dietary antioxidants, Clinical Biochemistry, Cellular homeostasis, such as polyphenols and L-carnitine/acetyl-L-carnitine, Biochemistry, Hsp70, Stress Response Signaling, and transcriptional processes. Maintenance of optimal long-term health conditions is accomplished by a complex network of longevity assurance processes that are controlled by vitagenes, Modulation of endogenous cellular defense mechanisms via the stress response signaling represents ad innovative approach to therapeutic intervention in diseases causing chronic damage, Stress, Physiological, Heat shock protein, Cellular stress response, challenges long-standing beliefs about the nature of the dose-response in a low dose zone, Animals, Homeostasis, Humans, Heat shock, biology, General Medicine, such as neurodegeneration and cancer. Protein thiols play a key role in redox sensing, including vitagenes. The hormetic dose-response, Cell biology, Heat shock factor, and regulation of cellular redox state is crucial mediator of multiple metabolic, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways, having the potential to affect significantly the design of. pre-clinical studies and clinical trials as well as strategies for optimal patient dosing in the treatment of numerous diseases. Given the broad cytoprotective properties of the heat shock response, the thioredoxin, Modulation of endogenous cellular defense mechanisms via the stress response signaling represents ad innovative approach to therapeutic intervention in diseases causing chronic damage, such as neurodegeneration and cancer. Protein thiols play a key role in redox sensing, and regulation of cellular redox state is crucial mediator of multiple metabolic, signaling, and transcriptional processes. Maintenance of optimal long-term health conditions is accomplished by a complex network of longevity assurance processes that are controlled by vitagenes, a group of genes involved in preserving cellular homeostasis during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Hsp70, the thioredoxin, and the sirtuin protein systems. Dietary antioxidants, such as polyphenols and L-carnitine/acetyl-L-carnitine, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways, including vitagenes. The hormetic dose-response, challenges long-standing beliefs about the nature of the dose-response in a low dose zone, having the potential to affect significantly the design of. pre-clinical studies and clinical trials as well as strategies for optimal patient dosing in the treatment of numerous diseases. Given the broad cytoprotective properties of the heat shock response, there is now strong interest in discovering and developing pharmacological agents capable of inducing these responses. In this review we discuss the most current and up-to-date understanding of the possible signaling mechanisms by which acetylcarnitine by activating vitagenes can differentially modulate signal transduction cascades inducing apoptosis/cell death in abnormal cancer cells but at the same time enhancing defensive enzymes to protect against carcinogenesis and neurodegeneration in normal cells, Cytoprotection, Sirtuin, biology.protein, a group of genes involved in preserving cellular homeostasis during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Molecular Medicine, Thioredoxin, there is now strong interest in discovering and developing pharmacological agents capable of inducing these responses. In this review we discuss the most current and up-to-date understanding of the possible signaling mechanisms by which acetylcarnitine by activating vitagenes can differentially modulate signal transduction cascades inducing apoptosis/cell death in abnormal cancer cells but at the same time enhancing defensive enzymes to protect against carcinogenesis and neurodegeneration in normal cells, signaling, Acetylcarnitine, Energy Metabolism, Molecular Chaperones
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1db97388cee7d07d428c80a3d0beb3Test
https://pubmed.ncbi.nlm.nih.gov/19449442Test -
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المؤلفون: Michael A. Costa, Laurence B. Davin, Huai Bin Wang, Masayuki Fujita, Albena T. Dinkova-Kostova, Vincent Burlat, Simo Sarkanen, David R. Gang, William Martin, Norman G. Lewis
المصدر: Chemistrybiology. 6(3)
مصطلحات موضوعية: DNA, Plant, Free Radicals, Clinical Biochemistry, Blotting, Western, Molecular Sequence Data, Biology, Biochemistry, Lignin, Polymerase Chain Reaction, Lignans, chemistry.chemical_compound, Epitopes, radical coupling, Drug Discovery, Amino Acid Sequence, dirigent protein, Molecular Biology, Peptide sequence, lignins, Plant Proteins, Pharmacology, chemistry.chemical_classification, Lignan, Genome, fungi, General Medicine, Plants, Recombinant Proteins, Amino acid, Blotting, Southern, Dirigent protein, chemistry, biology.protein, Molecular Medicine, Stereoselectivity, Monolignol, Function (biology), Subcellular Fractions
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe5dc60660a5ba899fde0ebfd2994e7Test
https://pubmed.ncbi.nlm.nih.gov/10074466Test -
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المؤلفون: Philip A. Cole, Ying Zhang, Vittorio Calabrese, Ronald J. Hicks, Young Hoon Ahn, Ivor J. Benjamin, Albena T. Dinkova-Kostova, Tadashi Honda
المصدر: Chemistry & Biology. (11):1355-1361
مصطلحات موضوعية: NF-E2-Related Factor 2, Clinical Biochemistry, Biology, Biochemistry, digestive system, environment and public health, Article, Cell Line, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, Heat Shock Transcription Factors, Heat shock protein, Drug Discovery, Animals, Humans, HSP70 Heat-Shock Proteins, Sulfhydryl Compounds, Heat shock, HSF1, Transcription factor, Molecular Biology, 030304 developmental biology, Pharmacology, 0303 health sciences, Kelch-Like ECH-Associated Protein 1, fungi, Intracellular Signaling Peptides and Proteins, General Medicine, respiratory system, KEAP1, Triterpenes, Hsp70, Cell biology, Up-Regulation, Heat shock factor, DNA-Binding Proteins, Molecular Medicine, Pentacyclic Triterpenes, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffedb8a0a3f46aa31dc08b85405b40ceTest
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المؤلفون: John Landers, J. Lawrence Marsh, Donald C. Lo, Teresa F. Pais, Eddine Saiah, Sébastien Moniot, Linda S. Kaltenbach, Aleksey G. Kazantsev, Clemens Steegborn, Michelle M. Maxwell, Sharadha Dayalan Naidu, Lisa Meisel, Albena T. Dinkova-Kostova, Leslie M. Thompson, Heike Runne, Michael J. Van Kanegan, Ryan G. Lim, Malcolm Casale, Judit Pallos, Nazifa Abdul Rauf, Ruben Abagyan, Luisa Quinti, Ruth Luthi-Carter, Dmitriy Leyfer
المصدر: Cell chemical biology, vol 23, iss 7
Quinti, L; Casale, M; Moniot, S; Pais, TF; Van Kanegan, MJ; Kaltenbach, LS; et al.(2016). SIRT2-and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models. CELL CHEMICAL BIOLOGY, 23(7), 849-861. doi: 10.1016/j.chembiol.2016.05.015. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3bp0f2h0Testمصطلحات موضوعية: Huntington's Disease, 0301 basic medicine, NF-E2-Related Factor 2, Stereochemistry, Systems biology, Clinical Biochemistry, Neurodegenerative, Pharmacology, SIRT2, Biochemistry, Neuroprotection, Cell Line, Dose-Response Relationship, Structure-Activity Relationship, 03 medical and health sciences, Sirtuin 2, Rare Diseases, Slice preparation, Huntington's disease, Drug Discovery, medicine, Animals, Structure–activity relationship, Molecular Biology, Dose-Response Relationship, Drug, Animal, Activator (genetics), Chemistry, Neurosciences, medicine.disease, Rats, Brain Disorders, Disease Models, Animal, Thiazoles, Huntington Disease, Neuroprotective Agents, Orphan Drug, 030104 developmental biology, 5.1 Pharmaceuticals, Cell culture, Disease Models, Neurological, Molecular Medicine, Drosophila, Development of treatments and therapeutic interventions, Drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f06b599a60590742964de076360eeb8Test
https://infoscience.epfl.ch/record/222350Test
