المؤلفون: Mai H. Mekkawy, Albena T. Dinkova-Kostova, Mostafa M. Ghorab, Heba M. Karam, Aiten M. Soliman, Maureen Higgins

المصدر: Bioorganicmedicinal chemistry letters. 42

مصطلحات موضوعية: Antioxidant, Halogenation, NF-E2-Related Factor 2, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, 01 natural sciences, Biochemistry, Median lethal dose, Antioxidants, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Humans, Molecular Biology, Quinazolinones, chemistry.chemical_classification, Reactive oxygen species, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Malondialdehyde, KEAP1, Molecular biology, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Oxidative Stress, Molecular Medicine, Oxidative stress, Acetamide

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a02466f1c4857fb78d12859b05326d5Test
https://pubmed.ncbi.nlm.nih.gov/33811990Test

المؤلفون: Suqing Zheng, René V. Bensasson, Albena T. Dinkova-Kostova, Wei Li, Akira Saito, Vincent Zoete, Tadashi Honda

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4345-4349

مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Electrons, Alkenes, 01 natural sciences, Biochemistry, Mice, 03 medical and health sciences, Cell Line, Tumor, Nitriles, Drug Discovery, NAD(P)H Dehydrogenase (Quinone), Animals, Potency, Reactivity (chemistry), Sulfhydryl Compounds, Enzyme inducer, Molecular Biology, HOMO/LUMO, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Molecular Structure, biology, Bicyclic molecule, 010405 organic chemistry, Chemistry, Organic Chemistry, Ketones, 0104 chemical sciences, 030104 developmental biology, Enzyme, Electron affinity (data page), Cyclization, Cytoprotection, Enzyme Induction, biology.protein, Quantum Theory, Molecular Medicine, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b72f814fedbc5f4e00f65a00584375eTest
https://doi.org/10.1016/j.bmcl.2016.07.028Test

المؤلفون: Emilie David, Chitra Sundararajan, Eric M. Padegimas, Albena T. Dinkova-Kostova, W. Christian Wigley, Melean Visnick, Tadashi Honda, Ron Bumeister

المصدر: Bioorganicmedicinal chemistry letters. 21(8)

مصطلحات موضوعية: Stereochemistry, medicine.drug_class, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Nitric Oxide, Biochemistry, Chemical synthesis, Anti-inflammatory, chemistry.chemical_compound, Interferon-gamma, Mice, Cell Line, Tumor, Drug Discovery, medicine, NAD(P)H Dehydrogenase (Quinone), Potency, Bioassay, Animals, Oleanolic Acid, Molecular Biology, Oleanolic acid, Chemistry, Organic Chemistry, Imidazoles, Biological activity, Cytoprotective Agent, In vitro, Cytoprotection, Molecular Medicine, Heme Oxygenase-1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c37e25ee20084c69fedc4c88ca8a4c85Test
https://pubmed.ncbi.nlm.nih.gov/21441026Test

المؤلفون: John D. Hayes, Larry G. Higgins, C. Roland Wolf, Xiu Jun Wang, Albena T. Dinkova-Kostova

المصدر: Chemistrybiology. 17(1)

مصطلحات موضوعية: Stereochemistry, NF-E2-Related Factor 2, Clinical Biochemistry, Catechols, medicine.disease_cause, Biochemistry, Cell Line, chemistry.chemical_compound, Catecholamines, Phenols, Genes, Reporter, Drug Discovery, medicine, Benzoquinones, Humans, Luciferase, Antioxidant Response Elements, Luciferases, Molecular Biology, Transcription factor, Pharmacology, A549 cell, Catechol, Kelch-Like ECH-Associated Protein 1, Chemistry, Intracellular Signaling Peptides and Proteins, Promoter, General Medicine, Glutathione, Hydroquinones, Oxygen, CHEMBIO, Gene Expression Regulation, SIGNALING, Electrophile, Molecular Medicine, Oxidation-Reduction, Oxidative stress, Copper

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4799c0a7deba539c7f4ec44bcb4e9352Test
https://pubmed.ncbi.nlm.nih.gov/20142043Test

المؤلفون: Michael A. Costa, Laurence B. Davin, Huai Bin Wang, Masayuki Fujita, Albena T. Dinkova-Kostova, Vincent Burlat, Simo Sarkanen, David R. Gang, William Martin, Norman G. Lewis

المصدر: Chemistrybiology. 6(3)

مصطلحات موضوعية: DNA, Plant, Free Radicals, Clinical Biochemistry, Blotting, Western, Molecular Sequence Data, Biology, Biochemistry, Lignin, Polymerase Chain Reaction, Lignans, chemistry.chemical_compound, Epitopes, radical coupling, Drug Discovery, Amino Acid Sequence, dirigent protein, Molecular Biology, Peptide sequence, lignins, Plant Proteins, Pharmacology, chemistry.chemical_classification, Lignan, Genome, fungi, General Medicine, Plants, Recombinant Proteins, Amino acid, Blotting, Southern, Dirigent protein, chemistry, biology.protein, Molecular Medicine, Stereoselectivity, Monolignol, Function (biology), Subcellular Fractions

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe5dc60660a5ba899fde0ebfd2994e7Test
https://pubmed.ncbi.nlm.nih.gov/10074466Test

المؤلفون: Philip A. Cole, Ying Zhang, Vittorio Calabrese, Ronald J. Hicks, Young Hoon Ahn, Ivor J. Benjamin, Albena T. Dinkova-Kostova, Tadashi Honda

المصدر: Chemistry & Biology. (11):1355-1361

مصطلحات موضوعية: NF-E2-Related Factor 2, Clinical Biochemistry, Biology, Biochemistry, digestive system, environment and public health, Article, Cell Line, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, Heat Shock Transcription Factors, Heat shock protein, Drug Discovery, Animals, Humans, HSP70 Heat-Shock Proteins, Sulfhydryl Compounds, Heat shock, HSF1, Transcription factor, Molecular Biology, 030304 developmental biology, Pharmacology, 0303 health sciences, Kelch-Like ECH-Associated Protein 1, fungi, Intracellular Signaling Peptides and Proteins, General Medicine, respiratory system, KEAP1, Triterpenes, Hsp70, Cell biology, Up-Regulation, Heat shock factor, DNA-Binding Proteins, Molecular Medicine, Pentacyclic Triterpenes, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffedb8a0a3f46aa31dc08b85405b40ceTest

المؤلفون: John Landers, J. Lawrence Marsh, Donald C. Lo, Teresa F. Pais, Eddine Saiah, Sébastien Moniot, Linda S. Kaltenbach, Aleksey G. Kazantsev, Clemens Steegborn, Michelle M. Maxwell, Sharadha Dayalan Naidu, Lisa Meisel, Albena T. Dinkova-Kostova, Leslie M. Thompson, Heike Runne, Michael J. Van Kanegan, Ryan G. Lim, Malcolm Casale, Judit Pallos, Nazifa Abdul Rauf, Ruben Abagyan, Luisa Quinti, Ruth Luthi-Carter, Dmitriy Leyfer

المصدر: Cell chemical biology, vol 23, iss 7
Quinti, L; Casale, M; Moniot, S; Pais, TF; Van Kanegan, MJ; Kaltenbach, LS; et al.(2016). SIRT2-and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models. CELL CHEMICAL BIOLOGY, 23(7), 849-861. doi: 10.1016/j.chembiol.2016.05.015. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3bp0f2h0Test

مصطلحات موضوعية: Huntington's Disease, 0301 basic medicine, NF-E2-Related Factor 2, Stereochemistry, Systems biology, Clinical Biochemistry, Neurodegenerative, Pharmacology, SIRT2, Biochemistry, Neuroprotection, Cell Line, Dose-Response Relationship, Structure-Activity Relationship, 03 medical and health sciences, Sirtuin 2, Rare Diseases, Slice preparation, Huntington's disease, Drug Discovery, medicine, Animals, Structure–activity relationship, Molecular Biology, Dose-Response Relationship, Drug, Animal, Activator (genetics), Chemistry, Neurosciences, medicine.disease, Rats, Brain Disorders, Disease Models, Animal, Thiazoles, Huntington Disease, Neuroprotective Agents, Orphan Drug, 030104 developmental biology, 5.1 Pharmaceuticals, Cell culture, Disease Models, Neurological, Molecular Medicine, Drosophila, Development of treatments and therapeutic interventions, Drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f06b599a60590742964de076360eeb8Test
https://infoscience.epfl.ch/record/222350Test