التفاصيل البيبلوغرافية
العنوان:
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-α levels in patients with gestational diabetes mellitus
المؤلفون:
Osman Ciftci , Rauf Melekoglu , Ercan Nurcan Yilmaz , Ebru Celik , Ayse Gulcin Bastemur
بيانات النشر:
Blackwell Publishing, 2019.
سنة النشر:
2019
مصطلحات موضوعية:
amnion fluid analysis , Amniotic fluid , thrombospondin , Gastroenterology , Pregnancy , gestational age , tumor necrosis factor-alpha , amnion , clinical article , medicine.diagnostic_test , biology , Amnion , amnion fluid , disease course , pathogenesis , Obstetrics and Gynecology , Gestational age , karyotyping , cohort analysis , ADAMTS4 protein, human , gestational diabetes mellitus , TNF protein, human , Gestational diabetes , A Disintegrin and Metalloprotease Protein , medicine.anatomical_structure , female , pregnancy diabetes mellitus , Pregnancy Trimester, Second , Cohort , Amniocentesis , ADAMTS4 Protein , Female , ADAMTS5 protein, human , prospective study , Adult , medicine.medical_specialty , tumor necrosis factor , ADAMTS4 Protein/*metabolism , ADAMTS5 Protein/*metabolism , Amniotic Fluid/*chemistry , Diabetes, Gestational/*metabolism , Humans , Interleukin-6/*metabolism , Pregnancy Trimester, Second/*metabolism , Tumor Necrosis Factor-alpha/*metabolism , interleukin 6 , IL6 protein, human , chemistry , Article , second trimester pregnancy , Internal medicine , medicine , aggrecanase 1 , controlled study , human , Interleukin 6 , business.industry , Interleukin-6 , Tumor Necrosis Factor-alpha , aggrecanase 2 , case control study , medicine.disease , Amniotic Fluid , body mass , Diabetes, Gestational , age , biology.protein , amniocentesis , ADAMTS5 Protein , business , Body mass index , metabolism
الوصف:
Aim: To test the hypothesis that altered A Disintegrin and Metalloproteinase Domains with Thrombospondins motifs (ADAMTS) is implicated in the etiopathogenesis of gestational diabetes mellitus (GDM). Methods: All pregnant women who underwent elective amniocentesis for karyotype analysis between January 1, 2016, and January 1, 2018, were included in this study. From this cohort, the study group consisting of 20 patients diagnosed with GDM was selected and compared against a control group consisting of 20 age- and body mass index (BMI)-matched patients without GDM. ADAMTS4, ADAMTS5, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) levels were compared in the second trimester amniotic fluid of patients with GDM and normoglycemic pregnant women. Results: No significant differences were observed between GDM and control groups regarding age, BMI, gestational age at amniocentesis and indication for amniocentesis. Mean amniotic fluid ADAMTS4 and ADAMTS5 levels were significantly increased in the GDM group compared with the control group (253.5 ± 18.7 pg/mL and 188.5 ± 21.3 pg/mL, P < 0.001; 192.9 ± 16.4 pg/mL and 154.8 ± 19.9 pg/mL, P = 0.021, respectively). Significant increases in IL-6 and TNF-α levels were also detected in the amniotic fluid of GDM patients relative to controls (136.2 ± 17.3 pg/mL and 98.3 ± 11.5 pg/mL, P < 0.001; 154.2 ± 12.5 pg/mL and 86.2 ± 10.8 pg/mL, P < 0.001, respectively). Conclusion: The data presented here suggest that increased levels of ADAMTS4, ADAMTS5, IL-6 and TNF-α may play an important role in the progression of GDM. © 2019 Japan Society of Obstetrics and Gynecology
اللغة:
English
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d970e0e847e97fe40e45e72ba775f41Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....3d970e0e847e97fe40e45e72ba775f41
قاعدة البيانات:
OpenAIRE
