التفاصيل البيبلوغرافية
| العنوان: |
Black Pigment Gallstone Inspired Platinum-Chelated Bilirubin Nanoparticles for Combined Photoacoustic Imaging and Photothermal Therapy of Cancers. |
| المؤلفون: |
Lee, Dong Yun, Kim, Jin Yong, Lee, Yonghyun, Lee, Soyoung, Miao, Wenjun, Kim, Hyeon Sik, Min, Jung‐Joon, Jon, Sangyong |
| المصدر: |
Angewandte Chemie; 10/23/2017, Vol. 129 Issue 44, p13872-13876, 5p |
| مصطلحات موضوعية: |
BILIRUBIN, ACOUSTIC imaging, CANCER treatment, CANCER cells, NANOMEDICINE |
| الملخص (بالإنجليزية): |
Bilirubin (BR), a bile pigment that exerts potent antioxidant and anti-inflammatory effects, is also a major constituent of black pigment gallstones found in bile ducts under certain pathological conditions. Inspired by the intrinsic metal-chelating power of BR found in gallstones, herein we report a cisplatin-chelated BR-based nanoparticle (cisPt@BRNP) for use as a new photonic nanomedicine for combined photoacoustic imaging and photothermal therapy of cancers. The cisPt@BRNPs were prepared by simply mixing cisplatin with BRNPs, yielding ca. 150-nm-size NPs. Upon near-IR laser irradiation at 808 nm, cisPt@BRNPs generated considerable heat and induced clear death of cancer cells in vitro. Following intravenous injection into human colon cancer-bearing mice, cisPt@BRNPs allowed effective tumor visualization by photoacoustic imaging and remarkable antitumor efficacy by photothermal therapy, suggesting their potential for use as a new photonic nanomedicine for cancer therapy. [ABSTRACT FROM AUTHOR] |
| Abstract (German): |
Gallig gegen Krebs: Biologisch verträgliche und abbaubare, auf Nahinfrarotlicht reagierende photonische Nanomaterialien auf Basis des metallchelatisierenden Gallenfarbstoffs Bilirubin wurden entwickelt. Bilirubin‐Nanopartikel mit chelatisiertem Cisplatin (cisPt@BRNPs) sind vielversprechend für eine kombinierte Krebsbehandlungen mit photoakustischer Bildgebung (PAI) und Photothermaltherapie (PTT). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
