Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring
| العنوان: | Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring |
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| المؤلفون: | Wen Li, Ji-Bin Liu, Li-Kun Hou, Fei Yu, Jie Zhang, Wei Wu, Xiao-Mei Tang, Feng Sun, Hai-Min Lu, Jing Deng, Jie Bai, Juan Li, Chun-Yan Wu, Qin-Lu Lin, Zhong-Wei Lv, Gao-Ren Wang, Geng-Xi Jiang, Yu-Shui Ma, Da Fu |
| المصدر: | Molecular Cancer Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022) |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cancer Research, Lung Neoplasms, Liquid biopsy, Clinical Decision-Making, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Disease Management, High-Throughput Nucleotide Sequencing, Review, ctDNA, Exosomes, Neoplastic Cells, Circulating, Prognosis, Circulating Tumor DNA, Oncology, Biomarkers, Tumor, Animals, Humans, Molecular Medicine, Disease Susceptibility, Lung cancer, CTCs, Diagnostics, RC254-282 |
| الوصف: | Primary lung cancer is one of the most common malignant tumors in China. Approximately 60% of lung cancer patients have distant metastasis at the initial diagnosis, so it is necessary to find new tumor markers for early diagnosis and individualized treatment. Tumor markers contribute to the early diagnosis of lung cancer and play important roles in early detection and treatment, as well as in precision medicine, efficacy monitoring, and prognosis prediction. The pathological diagnosis of lung cancer in small biopsy specimens determines whether there are tumor cells in the biopsy and tumor type. Because biopsy is traumatic and the compliance of patients with multiple biopsies is poor, liquid biopsy has become a hot research direction. Liquid biopsies are advantageous because they are nontraumatic, easy to obtain, reflect the overall state of the tumor, and allow for real-time monitoring. At present, liquid biopsies mainly include circulating tumor cells, circulating tumor DNA, exosomes, microRNA, circulating RNA, tumor platelets, and tumor endothelial cells. This review introduces the research progress and clinical application prospect of liquid biopsy technology for lung cancer. |
| تدمد: | 1476-4598 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9baea70a88bf796087ab3c0fe3d98a32Test https://doi.org/10.1186/s12943-022-01505-zTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9baea70a88bf796087ab3c0fe3d98a32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14764598 |
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