التفاصيل البيبلوغرافية
| العنوان: |
Application prospect of circular RNA-based neoantigen vaccine in tumor immunotherapy. |
| المؤلفون: |
Li, Mohan1,2,3 (AUTHOR), Wang, Yian1,4 (AUTHOR), Wu, Pan2 (AUTHOR), Zhang, Shanshan3 (AUTHOR), Gong, Zhaojian5 (AUTHOR), Liao, Qianjin1 (AUTHOR), Guo, Can2 (AUTHOR), Wang, Fuyan2 (AUTHOR), Li, Yong2 (AUTHOR), Zeng, Zhaoyang1,2 (AUTHOR), Yan, Qijia1,2,3 (AUTHOR) yanqijia77@126.com, Xiong, Wei1,2 (AUTHOR) xiongwei@csu.edu.cn |
| المصدر: |
Cancer Letters. Jun2023, Vol. 563, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*CANCER vaccines, *CIRCULAR RNA, *NON-coding RNA, *TUMOR proteins, *PEPTIDES, *SYNCRIP protein, *BACTERIAL vaccines |
| مستخلص: |
Neoantigen is a protein produced by mutant gene, which is only expressed in tumor cells. It is an ideal target for therapeutic tumor vaccines. Although synthetic long peptide (SLP)-based neoantigen vaccine, DNA-based neoantigen vaccine, and mRNA-based neoantigen vaccine are all in the development stage, they have some inherent shortcomings. Therefore, researchers turned their attention to a new type of "non-coding RNA (ncRNA)", circular RNA (circRNA), for potential better choice. Because of its unique high stability and protein-coding capacity, circRNA is a promising target in the field of neoantigen vaccine. In this paper, we reviewed the feasibility of circRNA encoding neoantigens, summarized the construction process, explained the mechanism of circRNA vaccine in vitro , and discussed the advantages and disadvantages of circRNA vaccine and possible combination with other immunotherapies. • Tumor vaccine is a new direction of cancer prevention and treatment. • Tumor neoantigens are tumor specific proteins and are ideal targets for tumor vaccines. • circRNA can be used as a vector for tumor vaccines because of its ability to encode small peptides. • In this paper, the construction method and application prospect of circRNA vaccine are described in detail. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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