Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study
| العنوان: | Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study |
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| المؤلفون: | Alessio Luzi, Ottavia Porzio, Rainer H. Böger, Arianna Massimi, Rossella Menghini, Andrea Magrini, Nikolaus Marx, Massimo Federici, Juliane Hannemann, Maria Mavilio, Peter J. Grant, Stefano Rizza, Michael Lehrke, Bart Staels, Marta Ballanti |
| المصدر: | Acta Diabetologica |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Gene Expression, Nurses, Settore MED/09, Blood Pressure, Pittsburgh Sleep Quality Index, Leukocyte Count, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Medicine, Subclinical infection, Diabetes, Circadian, ARNTL Transcription Factors, Shift Work Schedule, General Medicine, Middle Aged, Hospitals, Circadian Rhythm, medicine.anatomical_structure, Female, Original Article, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, 03 medical and health sciences, Insulin resistance, Internal medicine, White blood cell, Diabetes mellitus, Internal Medicine, Humans, Obesity, Circadian rhythm, Glycated Hemoglobin, Inflammation, business.industry, medicine.disease, Cross-Sectional Studies, 030104 developmental biology, Blood pressure, chemistry, Nuclear Receptor Subfamily 1, Group D, Member 1, Leukocytes, Mononuclear, RNA, Glycated hemoglobin, Sleep, business |
| الوصف: | Objective To detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms. Design and methods We performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW, n = 111) and former (f-NSW, n = 98) rotating night shift workers with diurnal workers (controls, n = 69). All participants were hospital nurses. We also evaluated the Pittsburgh Sleep Quality Index (PSQI) and assessed expression of transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs), as indicators of the molecular clock. Results Both a-NSW and f-NSW participants had significantly higher glycated hemoglobin (HbA1c) and white blood cell counts (WBC) (p p = 0.001) and diastolic blood pressure levels (p = 0.024) compared with controls. Expression of REV-ERBα/BMAL1 RNA in PBMC was significantly higher in a-NSW (p = 0.05) than in f-NSW or control participants. Multivariate regression analysis showed that working status and PSQI were independent determinants of higher HbA1c levels (p Conclusions We demonstrated that young, healthy night shift workers show subclinical abnormalities in HbA1c and changes in peripheral clock gene expression. |
| تدمد: | 1432-5233 0940-5429 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cba2c39f09c228f8cbf55086fac5f83Test https://doi.org/10.1007/s00592-021-01676-zTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3cba2c39f09c228f8cbf55086fac5f83 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14325233 09405429 |
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