دورية أكاديمية
HLA-B*57 and IFNL4-Related Polymorphisms Are Associated With Protection Against HIV-1 Disease Progression in Controllers
| العنوان: | HLA-B*57 and IFNL4-Related Polymorphisms Are Associated With Protection Against HIV-1 Disease Progression in Controllers |
|---|---|
| المؤلفون: | Dominguez-Molina B, Tarancon-Diez L, Hua S, Abad-Molina C, Rodriguez-Gallego E, Machmach K, Vidal F, Tural C, Moreno S, Goñi JM, Ramírez de Arellano E, Del Val M, Gonzalez-Escribano MF, Del Romero J, Rodriguez C, Capa L, Viciana P, Alcamí J, Yu XG, Walker BD, Leal M, Lichterfeld M, Ruiz-Mateos E, ECRIS integrated in the Spanish AIDS Research Network |
| المساهمون: | Universitat Rovira i Virgili |
| المصدر: | Clinical Infectious Diseases ; 10.1093/cid/ciw833 ; Clinical Infectious Diseases. 64 (5): 621-628 |
| سنة النشر: | 2017 |
| المجموعة: | Universitat Rovira i Virgili: Repositori institucional URV |
| مصطلحات موضوعية: | Immunology,Infectious Diseases,Microbiology,Microbiology (Medical), Progression, ifnl4, hla-b*57, hiv-controllers, Saúde coletiva, Odontología, Microbiology (medical), Microbiology, Medicina veterinaria, Medicina iii, Medicina ii, Medicina i, Interdisciplinar, Infectious diseases, Immunology, General medicine, Farmacia, Engenharias ii, Engenharias i, Enfermagem, Ciências biológicas iii, Ciências biológicas ii, Ciências biológicas i, Biotecnología, Biodiversidade |
| الوصف: | Background. Human immunodeficiency virus type 1 (HIV-1) controllers maintain HIV-1 viremia at low levels (normally <2000 HIV-RNA copies/mL) without antiretroviral treatment. However, some HIV-1 controllers have evidence of immunologic progression with marked CD4+ T-cell decline. We investigated host genetic factors associated with protection against CD4+ T-cell loss in HIV-1 controllers. Methods. We analyzed the association of interferon-lambda 4 (IFNL4)-related polymorphisms and human leukocyte antigen (HLA)-B haplotypes within long-term nonprogressor HIV-1 controllers (LTNP-Cs; defined by maintaining CD4+ T-cells counts >500 cells/mm3 for more than 7 years after HIV-1 diagnosis) vs non-LTNP-Cs who developed CD4+ T-cell counts <500 cells/mm3. Both a Spanish study cohort (n = 140) and an international validation cohort (n = 914) were examined. Additionally, in a subgroup of individuals, HIV-1-specific T-cell responses and soluble cytokines were analyzed. Results. HLA-B∗57 was independently associated with the LTNP-C phenotype (odds ratio [OR], 3.056 [1.029-9.069]; P = .044 and OR, 1.924 [1.252-2.957]; P = .003) while IFNL4 genotypes represented independent factors for becoming non-LTNP-C (TT/TT, ss469415590; OR, 0.401 [0.171-0.942]; P = .036 or A/A, rs12980275; OR, 0.637 [0.434-0.934]; P = .021) in the Spanish and validation cohorts, respectively, after adjusting for sex, age at HIV-1 diagnosis, IFNL4-related polymorphisms, and different HLA-B haplotypes. LTNP-Cs showed lower plasma induced protein 10 (P = .019) and higher IFN-γ (P = .02) levels than the HIV-1 controllers with diminished CD4+ T-cell numbers. Moreover, LTNP-Cs exhibited higher quantities of interleukin (IL)2+CD57- and IFN-γ +CD57-HIV-1-specific CD8+ T cells (P = .002 and .041, respectively) than non-LTNP |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | unknown |
| العلاقة: | http://hdl.handle.net/20.500.11797/imarina3661866Test |
| الإتاحة: | https://doi.org/20.500.11797/imarina3661866Test https://doi.org/10.1093/cid/ciw833Test https://hdl.handle.net/20.500.11797/imarina3661866Test |
| حقوق: | openAccess |
| رقم الانضمام: | edsbas.7A7D5AD1 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |