التفاصيل البيبلوغرافية
| العنوان: |
Acute Myocardial Infarction in a Child with Systemic Lupus Erythematosus and Antiphospholipid Syndrome. |
| العنوان البديل: |
Sistemik Lupus Eritematozus ve Antifosfotipid Sendromu Olan Çocukta Akut Miyokard Enfarktüsü: Olgu Sunumu. (Turkish) |
| المؤلفون: |
Ayala, Zoilo Morel, Martínez, Rogelio, Mendieta, Samara, Benadón, Eduardo, Faugier, Enrique, Maldonado-Velázquez, María del Rocío |
| المصدر: |
Turkish Journal of Rheumatology; Sep2009, Vol. 24 Issue 3, p156-158, 3p, 1 Color Photograph, 1 Graph |
| مصطلحات موضوعية: |
MYOCARDIAL infarction, JUVENILE diseases, SYSTEMIC lupus erythematosus, ANTIPHOSPHOLIPID syndrome, CHRONIC pain, AUTOIMMUNE diseases, ARTERIAL diseases, CARCINOGENESIS, PHOSPHOLIPID antibodies |
| الملخص (بالإنجليزية): |
Systemic lupus erythematosus (SLE) is a chronic, autoimmune, complex, multi-organic and episodic disease. Approximately 15% of all cases experience onset in childhood and adolescence. The coronary pathology has been recognized as the primary cause of morbidity and mortality in patients with SLE, with an incidence 9 times higher and an attributed mortality of up to 36%. Different mechanisms, alone or combined, have been implicated in the pathogenesis of coronary disease in patients with SLE. The procoagulant state in SLE patients promotes the development of acute coronary events, determined not only by the antiphospholipid antibodies, but also by the high levels of fibrinogen and plasminogen inhibitor-1. The antiphospholipid syndrome (APS) is characterized by vascular thrombosis, pregnancy loss, and thrombocytopenia with antiphospholipid antibodies. The cardiac system is one of the primary targets in APS. Patients with SLE and APS have an increase risk of acute myocardial infarction (10 times greater). Prospective studies have demonstrated the association between antiphospholipid antibodies and the first episode of venous thrombosis, acute myocardial infarction and cerebral vascular accidents. We present the clinical case of a 13-year-old male with a diagnosis of SLE and secondary APS with an extensive acute myocardial infarction. In our patient, coronary alterations were not found, which correlates more to APS. It is important to remember that patients with SLE and secondary APS may develop thrombotic complications at any level, and even though thrombotic or ischemic cardiac events are unusual, they must always be considered. [ABSTRACT FROM AUTHOR] |
| Abstract (Turkish): |
Sistemik lupus eritematozus kronik, otoimmun, kompleks, multiorgan tutulumlu ve epizodik bir hastalıktır. Olguların yaklaşık %15'i çocukluk ve adölesan dönemde başlar. SLE gelişen hastalarda koroner patoloji görülme oranı 9 kat fazla olup %36'lara kadar çıkar. Bu nedenle en büyük morbidite ve mortalite nedenidir. Koroner hastalığın patogenezinde bir arada veya farklı işleyen çeşitli mekanizmalar sorumlu tutulmuştur. SLE'de görülen prokoagülan durum akut koroner olaylarının gelişimini hızlandırır. Bu durumdan sadece antifosfolipid antikorlar değil, yüksek fibrinojen ve plazminojen inhibitörü-1 düzeyleri de sorumludur. Antifosfolipid sendromu (APS), vasküler tromboz, düşük yapma ve trombositopeni ile karakterizedir. Kardiyak sistem APS'de primer hedeflerden birisidir. SLE ve APS'li hastalarda akut miyokard enfarktüsü gelişme riski 10 kat daha fazladır. Antifosfolipid antikorları ile venöz tromboz, akut miyokard enfarktüsü ve serebrobasküler olaylar arasındaki ilişki prospektif çalışmalar ile gösterilmiştir. Burada 13 yaşında SLE ve sekonder APS tanısı konulan ve ağır miyokard enfarktüsü olan bir erkek olguyu sunuyoruz. Hastamızda koroner değişimler bulunmaması daha çok APS ile ilişkilidir. SLE ve sekonder APS olan hastalarda, herhangi bir dönemde trombotik komplikasyonlar gelişebileceği hatırlanmalı ve seyrek de olsa trombotik yada iskemik kardiyak olaylar akla getirilmelidir. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
