Hereditary Polycystic Kidney Disease Associated with Osteorenal Syndrome in Rats
| العنوان: | Hereditary Polycystic Kidney Disease Associated with Osteorenal Syndrome in Rats |
|---|---|
| المؤلفون: | K. G. Rapp, F. Deerberg, J. Kaspareit-Rittinghausen, A. Wcislo, C. Messow |
| المصدر: | Veterinary Pathology. 26:195-201 |
| بيانات النشر: | SAGE Publications, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Heterozygote, medicine.medical_specialty, 040301 veterinary sciences, Kidney, Blood Urea Nitrogen, Enteritis, 0403 veterinary science, 03 medical and health sciences, Cecum, Internal medicine, medicine, Polycystic kidney disease, Animals, Blood urea nitrogen, Chronic Kidney Disease-Mineral and Bone Disorder, Polycystic Kidney Diseases, Sex Characteristics, Hyperparathyroidism, General Veterinary, Metastatic calcification, business.industry, Homozygote, Calcinosis, Heterozygote advantage, 04 agricultural and veterinary sciences, medicine.disease, Pedigree, Rats, Disease Models, Animal, Phenotype, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Kidney Failure, Chronic, Female, Hyperparathyroidism, Secondary, Secondary hyperparathyroidism, business |
| الوصف: | Hereditary polycystic kidney disease (PKD) was seen in Han: SPRD rats and identified as an autosomal, incomplete dominant trait. Homozygous animals died at 3 to 4 weeks of age, while heterozygous males were severely ill or moribund within about 6 months. Heterozygous females developed PKD to a lesser extent than males and survived longer. Renal secondary hyperparathyroidism and osteodystrophia fibrosa were seen in most males but were absent in females. In male rats metastatic calcification was found in kidneys, lungs, glandular and forestomach, blood vessels, and heart. In a few uremic males ulcerative enteritis occurred in cecum and colon. Blood urea nitrogen values were significantly increased in both sexes. |
| تدمد: | 1544-2217 0300-9858 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d655a2a8420b7c8b1db8969c142a575Test https://doi.org/10.1177/030098588902600302Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....3d655a2a8420b7c8b1db8969c142a575 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15442217 03009858 |
|---|