التفاصيل البيبلوغرافية
| العنوان: |
Postoperative evaluation of olfactory dysfunction in eosinophilic chronic rhinosinusitis – comparison of histopathological and clinical findings. |
| المؤلفون: |
Kashiwagi, Takashi, Tsunemi, Yasuhiro, Akutsu, Makoto, Nakajima, Itsuo, Haruna, Shinichi |
| المصدر: |
Acta Oto-Laryngologica; Oct2019, Vol. 139 Issue 10, p881-889, 9p |
| مصطلحات موضوعية: |
PARANASAL sinus surgery, CHRONIC diseases, COMPUTED tomography, ENDOSCOPY, EOSINOPHILIA, EOSINOPHILS, EPITHELIAL cells, HISTOLOGICAL techniques, INFLAMMATION, NERVE tissue proteins, NEUROLOGIC examination, NOSE, POSTOPERATIVE period, RESPIRATORY obstructions, SINUSITIS, SMELL disorders, DISEASE relapse, DISEASE complications, DISEASE risk factors |
| الملخص (بالإنجليزية): |
Background: Olfactory dysfunction in eosinophilic chronic rhinosinusitis (ECRS) is poorly understood. Objective: To compare olfactory mucosal injury due to eosinophil infiltration in ECRS with postoperative olfactory function. Methods: Seventeen ECRS patients (ECRS group) and 18 bilateral rhinosinusitis (non-ECRS group) patients were compared. At 3 and 12 months post-endoscopic sinus surgery (ESS), all patients were evaluated for subjective symptoms (nasal obstruction, nasal discharge and olfactory dysfunction), endoscopic nasal findings, CT score and T&T olfactometer recognition threshold test. The eosinophil count, OMP-positive cells and epithelial erosion in olfactory mucosa collected during ESS were compared with the postoperative olfactory function. Results: The non-ECRS group showed significant improvement in all clinical findings at 3 and 12 months, but the ECRS group showed worsening of the olfactory dysfunction symptoms and T&T olfactometer recognition threshold at 12 months because of recurrence of sinusitis. The groups differed significantly in the ΔT&T value (i.e. pre-ESS T&T recognition threshold – post-ESS T&T recognition threshold) at both 3 and 12 months, and the degree of olfactory improvement differed. Histologically, the ECRS group showed significantly more eosinophils, fewer OMP-positive cells and greater epithelial erosion than the non-ECRS group. Conclusions: Eosinophilic inflammation was thought to cause olfactory mucosal injury/dysfunction. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): |
背景：嗜酸粒细胞性慢性鼻窦炎（ECRS）患者的嗅觉功能障碍尚不清楚。 目的：比较ECRS患者的嗜酸性粒细胞浸润致嗅粘膜损伤与术后嗅觉功能的关系。 方法：对17例（ECRS组）和18例（非ECRS组）双侧鼻窦炎患者进行比较。在鼻内镜鼻窦手术（ESS）后的3个月和12个月, 对所有患者的主观症状（鼻阻塞、鼻分泌物和嗅觉障碍）、鼻内镜检查结果、CT评分和T&T嗅觉仪识别阈值测试进行评估。比较ESS术中收集的嗅粘膜嗜酸性粒细胞计数、OMP阳性细胞和上皮糜烂与术后嗅觉功能的关系。 结果：非ECRS组在3个月和12个月时的所有临床表现均有明显改善, 但由于鼻窦炎复发, ECRS组在12个月时的嗅觉功能障碍症状和T&T嗅觉仪识别阈值均变得更糟。两组在3个月和12个月时的ΔT&T值（即ESS前T&T识别阈值-ESS后T&T识别阈值）有显著差异, 嗅觉改善程度也有差异。组织学上, ECRS组比非ECRS组表现出更多的嗜酸性粒细胞、更少的OMP阳性细胞和程度更大的上皮侵蚀。 结论：嗜酸性炎症被认为会导致嗅觉粘膜损伤或功能障碍 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
