المؤلفون: Grønbæk, Lisbet, Omeife, Harmony, Ban, Lu, Crooks, Colin J, Card, Timothy R, Jepsen, Peter, West, Joe

المصدر: Clinical Epidemiology; Jan2024, Vol. 16, p23-30, 8p

مصطلحات موضوعية: AUTOIMMUNE hepatitis, DISEASE risk factors, CHRONIC active hepatitis, ODDS ratio, SMOKING statistics, CASE-control method, SMOKING

مصطلحات جغرافية: ENGLAND

مستخلص: Purpose: Smoking is a risk factor for some autoimmune diseases, but its association with autoimmune hepatitis remains unknown. We conducted a population-based matched case–control study to examine the association between tobacco smoking and the risk of autoimmune hepatitis in England. Patients and Methods: From the Clinical Practice Research Datalink and linked Hospital Episode Statistics, 2005– 2017, we included 987 cases diagnosed with autoimmune hepatitis after age 18 years and up to 10 frequency-matched population controls per case. We used multiple logistic regression to estimate the odds ratio of autoimmune hepatitis in ever-smokers vs never-smokers, adjusting for sex, age, general practice, calendar time of registration with the general practice, and socioeconomic status. Results: The autoimmune hepatitis cases were more likely to be ever-smokers than the controls (44% vs 37%). The ever-smokers had an increased risk of autoimmune hepatitis compared with the never-smokers (adjusted odds ratio = 1.20, 95% confidence interval 1.03– 1.39). Conclusion: Smoking was associated with an increased risk of autoimmune hepatitis. Plain Language Summary: Autoimmune hepatitis is a chronic liver disease associated with genetic variants and environmental exposures, but the causes of autoimmune hepatitis remain unknown. Using registry data, we evaluated the association between tobacco smoking and the risk for autoimmune hepatitis. We found that tobacco smoking was associated with an increased risk of autoimmune hepatitis. [ABSTRACT FROM AUTHOR]

: Copyright of Clinical Epidemiology is the property of Dove Medical Press Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Grønbæk, Lisbet, Otete, Harmony, Ban, Lu, Crooks, Colin, Card, Timothy, Jepsen, Peter, West, Joe

المصدر: Grønbæk , L , Otete , H , Ban , L , Crooks , C , Card , T , Jepsen , P & West , J 2020 , ' Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study ' , Liver International , vol. 40 , no. 7 , pp. 1634-1644 . https://doi.org/10.1111/liv.14480Test

مصطلحات موضوعية: autoimmune, cohort study, epidemiology, hepatitis, incidence, prevalence, prognosis, registry, CRITERIA, AIH, DIAGNOSIS, CHRONIC ACTIVE HEPATITIS, LIVER-DISEASES, TIME, CIRRHOSIS, PRIMARY SCLEROSING CHOLANGITIS

الوصف: Background & Aims There are few population-based studies of the incidence and mortality of autoimmune hepatitis. The burden of the disease and how it has changed over time have not been fully explored. We conducted a population-based cohort study on the incidence and mortality of autoimmune hepatitis in England, 1997-2015. Methods From the Clinical Practice Research Datalink we included 882 patients diagnosed with autoimmune hepatitis in England, 1997-2015. The patients were followed through 2015, and we calculated the sex- and age-standardized incidence and prevalence of autoimmune hepatitis. We examined variation in incidence by sex, age, calendar year, geographical region and socioeconomic status, and incidence rate ratios were calculated with Poisson regression. We calculated all-cause and cause-specific mortality. Results The overall standardized incidence rate of autoimmune hepatitis was 2.08 (95% confidence interval 1.94-2.22) per 100,000 population per year, higher in women, higher in older age and independent of region and socioeconomic status. From 1997 to 2015 the incidence doubled from 1.27 (95% confidence interval 0.51-2.02) to 2.56 (95% confidence interval 1.79-3.33) per 100,000 population per year. The 10-year cumulative all-cause mortality was 31.9% (95% confidence interval 27.6-36.5), and the 10-year cumulative liver-related mortality, including hepatocellular carcinoma was similar to 10.5%. Conclusions This population-based study showed that the incidence of autoimmune hepatitis doubled over an eighteen-year period. The incidence was particularly high in older women and was similar across all regions of England and independent of socioeconomic status. Patients with autoimmune hepatitis had a high mortality.

الإتاحة: https://doi.org/10.1111/liv.14480Test
https://pure.au.dk/portal/da/publications/incidence-prevalence-and-mortality-of-autoimmune-hepatitis-in-england-19972015-a-populationbased-cohort-studyTest(0d36297d-523f-452d-acd6-8861dc3e011c).html
http://www.scopus.com/inward/record.url?scp=85084228523&partnerID=8YFLogxKTest

المؤلفون: Grønbæk, Lisbet, Otete, Harmony, Ban, Lu, Crooks, Colin, Card, Timothy, Jepsen, Peter, West, Joe

المصدر: Journal of Hepatology. Apr2019 Supplement, Vol. 70, pe394-e394. 1p.

مصطلحات موضوعية: *CHRONIC active hepatitis, *EXPERIMENTAL medicine, *COHORT analysis, *DISEASE prevalence, *MEDICAL research, *CLINICAL epidemiology

مصطلحات جغرافية: ENGLAND