التفاصيل البيبلوغرافية
| العنوان: |
Myelodysplastic syndrome in a patient with adult T-cell leukaemia. |
| المؤلفون: |
Kawabata, Hisashi, Utsunomiya, Atae, Hanada, Shuichi, Makino, Torahiko, Takatsuka, Yoshifusa, Takeuchi, Shogo, Suzuki, Shinsuke, Suzumiya, Junji, Ohshima, Kouichi, Horiike, Shigeo |
| المصدر: |
British Journal of Haematology; Sep99, Vol. 106 Issue 3, p702-705, 4p, 1 Black and White Photograph, 1 Diagram |
| مصطلحات موضوعية: |
MYELODYSPLASTIC syndromes, ADULT T-cell leukemia, CHROMOSOME abnormalities |
| مستخلص: |
A 53-year-old female who developed myelodysplastic syndrome (MDS) after chemotherapy for adult T-cell leukaemia (ATL) is described. The latent period of therapy-related MDS (t-MDS) from the time of diagnosis of ATL was approximately 35 months. Cytogenetic analysis of the bone marrow cells at the time of diagnosis of t-MDS revealed a clonal abnormality; 46,XX,add(7)(p13), der(17)t(3;17)(p11;p13). Although monoclonal integration of human T lymphotropic virus type I (HTLV-I) proviral DNA was detected in the peripheral blood lymphocytes at ATL diagnosis, bone marrow cells at t-MDS diagnosis did not show monoclonal integration of HTLV-I. To our knowledge, this is the first report of t-MDS associated with ATL. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
