دورية أكاديمية
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
| العنوان: | Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. |
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| المؤلفون: | Eeles RA, Olama AA, Benlloch S, Saunders EJ, Leongamornlert DA, Tymrakiewicz M, Ghoussaini M, Luccarini C, Dennis J, Jugurnauth Little S, Dadaev T, Neal DE, Hamdy FC, Donovan JL, Muir K, Giles GG, Severi G, Wiklund F, Gronberg H, Haiman CA, Schumacher F, Henderson BE, Le Marchand L, Lindstrom S, Kraft P, Hunter DJ, Gapstur S, Chanock SJ, Berndt SI, Albanes D, Andriole G, Schleutker J, Weischer M, Canzian F, Riboli E, Key TJ, Travis RC, Ingles SA, John EM, Hayes RB, Pharoah PD, Pashayan N, Khaw KT, Stanford JL, Ostrander EA, Signorello LB, Thibodeau SN, Schaid D, Maier C, Vogel W, Kibel AS, Cybulski C, Lubinski J, Cannon Albright L, Brenner H, Park JY, Kaneva R, Batra J, Spurdle AB, Clements JA, Teixeira MR, Dicks E, Lee A, Dunning AM, Baynes C, Conroy D, Maranian MJ, Ahmed S, Govindasami K, Guy M, Wilkinson RA, Sawyer EJ, Morgan A, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As NJ, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatananon A, Cox A, Southey MC, Hopper JL, English DR, Aly M, Adolfsson J, Xu J, Zheng SL, Yeager M, Kaaks R, Diver WR, Gaudet MM, Stern MC, Corral R, Joshi AD, Shahabi A, Wahlfors T, Tammela TL, Auvinen A, Virtamo J, Klarskov P, Nordestgaard BG, Røder MA, Nielsen SF, Bojesen SE, Siddiq A, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Blot WJ, Zheng W, Cai Q, McDonnell SK, Rinckleb AE, Drake B, Colditz G, Wokolorczyk D, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Sellers TA, Lin HY, Slavov C, Mitev V, Lose F, Srinivasan S, Maia S, Paulo P, Lange E, Cooney KA, Antoniou AC, Vincent D, Bacot F, Tessier DC, COGS–Cancer Research UK GWAS–ELLIPSE Initiative, Australian Prostate Cancer Bioresource, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK ProtecT Study Collaborators, PRACTICAL Consortium, Kote Jarai Z, Easton D.F., CAMPA, DANIELE |
| المساهمون: | Eeles, Ra, Olama, Aa, Benlloch, S, Saunders, Ej, Leongamornlert, Da, Tymrakiewicz, M, Ghoussaini, M, Luccarini, C, Dennis, J, Jugurnauth Little, S, Dadaev, T, Neal, De, Hamdy, Fc, Donovan, Jl, Muir, K, Giles, Gg, Severi, G, Wiklund, F, Gronberg, H, Haiman, Ca, Schumacher, F, Henderson, Be, Le Marchand, L, Lindstrom, S, Kraft, P, Hunter, Dj, Gapstur, S, Chanock, Sj, Berndt, Si, Albanes, D, Andriole, G, Schleutker, J, Weischer, M, Canzian, F, Riboli, E, Key, Tj, Travis, Rc, Campa, Daniele, Ingles, Sa, John, Em, Hayes, Rb, Pharoah, Pd, Pashayan, N, Khaw, Kt, Stanford, Jl, Ostrander, Ea, Signorello, Lb, Thibodeau, Sn, Schaid, D, Maier, C, Vogel, W, Kibel, A, Cybulski, C, Lubinski, J, Cannon Albright, L, Brenner, H, Park, Jy, Kaneva, R, Batra, J, Spurdle, Ab, Clements, Ja, Teixeira, Mr, Dicks, E, Lee, A, Dunning, Am, Baynes, C, Conroy, D, Maranian, Mj, Ahmed, S, Govindasami, K, Guy, M, Wilkinson, Ra, Sawyer, Ej, Morgan, A, Dearnaley, Dp, Horwich, A, Huddart, Ra, Khoo, V, Parker, Cc, Van As, Nj, Woodhouse, Cj, Thompson, A, Dudderidge, T, Ogden, C, Cooper, C, Lophatananon, A, Cox, A, Southey, Mc, Hopper, Jl, English, Dr, Aly, M, Adolfsson, J, Xu, J, Zheng, Sl, Yeager, M, Kaaks, R, Diver, Wr, Gaudet, Mm, Stern, Mc, Corral, R |
| سنة النشر: | 2013 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | breast cancer, cancer prognosi, cancer susceptibility, cell adhesion, cell cycle arrest, chromosome 14, chromosome 2, developed country, double stranded DNA break, embryo development, extracellular matrix, gene frequency, gene linkage disequilibrium, genetic association, genetic predisposition, genetic risk, genotype, Gleason score, heterozygote, human, intron, priority journal, promoter region, prostate cancer, quality control, regulator gene |
| الوصف: | Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10(-8)). More than 70 prostate cancer susceptibility loci, explaining ∼30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23535732; info:eu-repo/semantics/altIdentifier/wos/WOS:000316840600008; volume:45; issue:4; firstpage:385; lastpage:391; numberofpages:7; journal:NATURE GENETICS; http://hdl.handle.net/11568/458485Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84875739291 |
| DOI: | 10.1038/ng.2560 |
| الإتاحة: | https://doi.org/10.1038/ng.2560Test http://hdl.handle.net/11568/458485Test |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.E79C5C7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ng.2560 |
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