التفاصيل البيبلوغرافية
| العنوان: |
Airway models in a pandemic: Suitability of models in modeling SARS-CoV-2. |
| المؤلفون: |
Teo, Andrew, Chua, Caroline Lin Lin, Chan, Louisa L. Y. |
| المصدر: |
PLoS Pathogens; 3/29/2022, Vol. 18 Issue 3, p1-10, 10p |
| مصطلحات موضوعية: |
COVID-19, SARS-CoV-2, TRANSFORMING growth factors, CHROMATIN-remodeling complexes |
| مستخلص: |
In a global pandemic involving respiratory pathogens such as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), intensified scientific research is required to delineate pathways involved in infectivity, transmissibility, and pathogenicity of the causative pathogen. Alveolar organoids were shown to be more resistant to SARS-CoV-2 infection compared with bronchial organoids, possibly due to their lower levels of ACE2 expression; hence, SARS-CoV-2 demonstrates tissue tropism toward the bronchial region through microaerosol inhalation [[43], [48]]. Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation. [Extracted from the article] |
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| قاعدة البيانات: |
Complementary Index |
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