المؤلفون: Sahu, Biswajyoti, Hartonen, Tuomo, Pihlajamaa, Päivi, Wei, Bei, Dave, Kashyap, Zhu, Fangjie, Kaasinen, Eevi, Lidschreiber, Katja, Lidschreiber, Michael, Daub, Carsten O., Cramer, Patrick, Kivioja, Teemu, Taipale, Jussi

المساهمون: Research Programs Unit, Medicum, Department of Biochemistry and Developmental Biology, ATG - Applied Tumor Genomics, Faculty of Medicine, Institute for Molecular Medicine Finland, Jussi Taipale / Principal Investigator, HUSLAB, Department of Pathology

مصطلحات موضوعية: TRANSCRIPTION-FACTOR-BINDING, DEVELOPMENTAL ENHANCERS, ACTIVE ENHANCERS, DNA, CHROMATIN, PROTEINS, MAPS, SITE, SPECIFICITIES, EXPRESSION, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology

وصف الملف: application/pdf

العلاقة: We thank M. Taipale, S. Wickstrom and M. Vartiainen for critical reading of the manuscript; A. M. Luoto, K. Jussila and A. Kolterud for technical assistance; and L. Fei, J. Xia and N. Poddar for their help during the revision. We also thank HiLIFE research infrastructures, including Biomedium Functional Genomics, FIMM technology center and sequencing core facilities of Karolinska Institute and SciLifeLab. We wish to acknowledge CSC -IT Center for Science, Finland for computational resources. J.T. was supported by the Academy of Finland (Finnish Center of Excellence program grants 2012-2017, 250345 and 2018-2025, 312042), United Kingdom Research and Innovation Medical Research Council (grant MR/V000500/1) and Cancer Research UK (grant C55958/A28801/RG99643). B.S. was supported by the Academy of Finland (grants 274555 and 317807), the Finnish Cancer Foundation and the Sigrid Juselius and Jane and Aatos Erkko foundations. T.H. was supported by a personal grant from Emil Aaltonen Foundation, and P.P. was supported by the Academy of Finland (grant 288836). K.L., M.L. and P.C. were funded by The Center for Medical Innovation (CIMED) and SciLifeLab.; Sahu , B , Hartonen , T , Pihlajamaa , P , Wei , B , Dave , K , Zhu , F , Kaasinen , E , Lidschreiber , K , Lidschreiber , M , Daub , C O , Cramer , P , Kivioja , T & Taipale , J 2022 , ' Sequence determinants of human gene regulatory elements ' , Nature Genetics , vol. 54 , no. 3 , pp. 283-+ . https://doi.org/10.1038/s41588-021-01009-4Test; ORCID: /0000-0001-6576-5440/work/111914855; ORCID: /0000-0002-1333-8049/work/111917992; ORCID: /0000-0001-9725-6907/work/137860639; 85b88be6-7ee2-4fee-a838-7e05979d4837; http://hdl.handle.net/10138/342898Test; 000758968100001

الإتاحة: http://hdl.handle.net/10138/342898Test

المؤلفون: Biswajyoti Sahu, Tuomo Hartonen, Päivi Pihlajamaa, Bei Wei, Kashyap Dave, Fangjie Zhu, Eevi Kaasinen, Katja Lidschreiber, Michael Lidschreiber, Carsten O. Daub, Patrick Cramer, Teemu Kivioja, Jussi Taipale

المساهمون: Sahu, Biswajyoti [0000-0001-6576-5440], Pihlajamaa, Päivi [0000-0001-9725-6907], Kaasinen, Eevi [0000-0002-1333-8049], Lidschreiber, Katja [0000-0001-6319-1076], Lidschreiber, Michael [0000-0002-6740-2755], Daub, Carsten O [0000-0002-3295-8729], Cramer, Patrick [0000-0001-5454-7755], Taipale, Jussi [0000-0003-4204-0951], Apollo - University of Cambridge Repository, Research Programs Unit, Medicum, Department of Biochemistry and Developmental Biology, ATG - Applied Tumor Genomics, Faculty of Medicine, Institute for Molecular Medicine Finland, Jussi Taipale / Principal Investigator, HUSLAB, Department of Pathology

المصدر: Nature Genetics

مصطلحات موضوعية: CHROMATIN, EXPRESSION, TRANSCRIPTION-FACTOR-BINDING, Binding Sites, PROTEINS, Genome, Human, SPECIFICITIES, fungi, 1184 Genetics, developmental biology, physiology, SITE, DNA, Regulatory Sequences, Nucleic Acid, ACTIVE ENHANCERS, humanities, MAPS, Genetics, DEVELOPMENTAL ENHANCERS, Humans, 3111 Biomedicine, Protein Binding, Transcription Factors

وصف الملف: application/pdf; text/xml; application/zip

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a921b9355f20739b39b8d1b6f0a9a6fTest