Effect of milk fat on LDL cholesterol and other cardiovascular risk markers in healthy humans: the INNOVALAIT project
| العنوان: | Effect of milk fat on LDL cholesterol and other cardiovascular risk markers in healthy humans: the INNOVALAIT project |
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| المؤلفون: | Bard, Jean-Marie, Drouet, Ludovic, Lairon, Denis, Cazaubiel, Murielle, Marmonier, Corinne, Ninio, Ewa, Bal dit Sollier, Claire, Martin, Jean-Charles, Boyer, Constance, Bobin-Dubigeon, Christine, LeRuyet, Pascale, Moreau, Daniel, goldschmidt, Benoît, Bonneau, Michel, Marchal, Philippe, Durand, Hervé |
| المساهمون: | Mer, molécules et santé EA 2160 (MMS), Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN)-Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biofortis, Centre National Interprofessionnel de l'Economie Laitière (CNIEL), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Groupe Lactalis, Entremont Alliance, Partenaires INRAE, Unité de recherche sur les Biopolymères, Interactions Assemblages (BIA), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche d'Écologie et Physiologie du Système Digestif (UEPSD), Institut National de la Recherche Agronomique (INRA), Bba, Sorbonne Université (SU), Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| المصدر: | European Journal of Clinical Nutrition European Journal of Clinical Nutrition, Nature Publishing Group, 2020, 74 (2), pp.285-296. ⟨10.1038/s41430-019-0528-4⟩ European Journal of Clinical Nutrition, 2020, 74 (2), pp.285-296. ⟨10.1038/s41430-019-0528-4⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Medicine (miscellaneous), chemistry.chemical_element, 030209 endocrinology & metabolism, Calcium, Palmitic acid, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Animals, Humans, Medicine, Food science, Triglycerides, 2. Zero hunger, chemistry.chemical_classification, Ldl cholesterol, Meal, 030109 nutrition & dietetics, Nutrition and Dietetics, Cholesterol, business.industry, Cholesterol, HDL, Fatty acid, Cholesterol, LDL, Dietary Fats, 3. Good health, Milk, chemistry, Cardiovascular Diseases, Heart Disease Risk Factors, Milk fat, Saturated fatty acid, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience; Background Milk has a specific saturated fatty acid profile and its calcium content may change the kinetics of fat absorption. Objective The goal of this study was to compare the effect on LDL Cholesterol and other risk markers of four isolipidic diets differing by their fat food source, vegetable fat, spring milk fat, winter milk fat or winter milk fat supplemented with calcium, in healthy moderately hypercholesterolemic humans. Individuals and methods This double-blind, randomized trial with four parallel arms included 172 healthy adults with plasma LDL cholesterol (LDL-C) from 130 to 220 mg/dL and triglycerides below 300 mg/dL. Individual meal plans ensured a stable energy intake. In the three diets containing milk fat, milk fat provided 38% of energy. Vegetable fat and spring milk fat diets provided the same amount of saturated fatty acids while the winter milk fat diets were slightly richer in saturated fatty acids. Vegetable fat diet and winter milk fat diets provided the same amount of palmitic acid (7.0% EI), while the spring milk fat diet was slightly poorer in this fatty acid (5.1% EI). Cardiovascular risk markers were analyzed after 8 weeks of dietary intervention. Results There was no significant difference in LDL-C and other markers, except total cholesterol (TC), apo C3 and CRP. TC was significantly higher with spring milk fat than with vegetable fat. Conclusions In this trial, the chosen vegetable fat did not have a significant beneficial effect on LDL-C compared to dairy fat. However, sub-group analysis showed differences in TC, apo C3 and CRP. These results need confirmation and long-term studies aiming at cardiovascular endpoints are warranted. |
| اللغة: | English |
| تدمد: | 0954-3007 1476-5640 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24b6276499ae4e56e592b660f1e7b38Test https://hal.inrae.fr/hal-02622670Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d24b6276499ae4e56e592b660f1e7b38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09543007 14765640 |
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