Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots
| العنوان: | Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots |
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| المؤلفون: | Simona Conea, Claudia Crina Toma, Oliviu Vostinaru, Irina Cazacu, Laurian Vlase, Cristina Pop, Ioana Cuc Hepcal, Cristina Mogosan |
| المصدر: | Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 45:59-64 |
| بيانات النشر: | University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0106 biological sciences, Traditional medicine, medicine.drug_class, Stereochemistry, Plant Science, Horticulture, 01 natural sciences, Quercitrin, Anti-inflammatory, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Acetic acid, chemistry.chemical_compound, Nociception, chemistry, Chlorogenic acid, Polyphenol, Randall–Selitto test, Arctium lappa, medicine, Agronomy and Crop Science, 010606 plant biology & botany |
| الوصف: | The aim of the study was to assess the polyphenolic profile, anti-inflammatory and antinociceptive activity of Arctium lappa, a medicinal plant traditionally used in the treatment of gout, hepatitis and other inflammatory disorders. Polyphenolic profile of a hydro-glycero-ethanolic extract from Arctium lappa roots (ALE) was evaluated by HPLC-MS method. Anti-inflammatory effect of the Arctium lappa extract (ALE) was determined by carrageenan-induced rat paw oedema test, while antinociceptive effect was determined by acetic acid induced writhing test in mice and Randall Selitto test in rats. HPLC-MS analysis of the extract showed the presence of chlorogenic acid (158.9 μg/mL) and quercitrin (14.4 μg/mL). The administration of ALE reduced the oedema formation in the carrageenan-induced rat paw oedema test, especially at dose of 500 mg/kg, the results being statistically significant and dose-dependent. Also, ALE showed statistically significant and dose-dependent antinociceptive effects in the acetic acid induced writhing test in mice and Randall Selitto test in rats. The results of the pharmacological experiments suggest that the anti-inflammatory and antinociceptive effects of the Arctium lappa extract (ALE) may be related to the ability of polyphenols such as chlorogenic acid to inhibit the synthesis and release of some pro-inflammatory mediators. Our experimental data justify the traditional use of this plant in the management of some inflammatory disease. |
| تدمد: | 1842-4309 0255-965X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::ec14047abe32e021b33d1e5d7a9a0612Test https://doi.org/10.15835/nbha45110549Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........ec14047abe32e021b33d1e5d7a9a0612 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18424309 0255965X |
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