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1دورية أكاديمية
المؤلفون: Forte, D, Nabais, A, Pontinha, C, Mafra, M, Mateus, L
مصطلحات موضوعية: Adult, Astrocytoma, Brain, Female, HIV Infections, HIV-1, Humans, Infratentorial Neoplasms, Neoplasms, Multiple Primary, Neurofibromatosis 1, Supratentorial Neoplasms, CHLC NCIR, CHLC PAT CLIN
الوصف: BACKGROUND: Neurofibromatosis type 1 (NF1) has been identified as a predisposing factor in the development of pilocytic astrocytoma (PA), a common benign central nervous system tumor. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in nonoptic and hypothalamic locations. CASE DESCRIPTION: A 41-year-old female patient with NF1 and uncontrolled human immunodeficiency virus (HIV) type 1 infection presented with a first generalized seizure and associated headache and ataxia. Imaging studies revealed 2 large intra-axial PAs, nodular-cystic in the supratentorial compartment and solid in the infratentorial compartment. Both lesions were treated by gross total resection in 2 surgeries performed 1 week apart. Despite their different imaging patterns, the tumors were histologically and genetically identical. CONCLUSIONS: We present a unique case involving 2 histologically and genetically identical PAs occurring simultaneously in supratentorial and infratentorial locations. We suggest that an intrinsic predisposition to tumor development in patients with NF1 might have been enhanced by the HIV-related immunosuppression in this case. Strict oncologic surveillance is essential in patients with a tumor predisposition syndrome combined with immunosuppression. ; info:eu-repo/semantics/publishedVersion
العلاقة: World Neurosurg. 2018 Sep;117:172-177.; http://hdl.handle.net/10400.17/3388Test
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2دورية أكاديمية
المؤلفون: Forte, Da, Irañeta, A, Nabais, A, Figueiredo, A, Mafra, M, Gonçalves, V
مصطلحات موضوعية: CHLC NCIR, CHLC PAT CLIN, Lobular Capillary Hemangioma, Pyogenic Granuloma, Endoscopic Transsphenoidal Pituitary Surgery
الوصف: Background Lobular capillary hemangioma is a rare benign tumor, most frequently located in the head or neck region, the nasal cavity being uncommonly affected. Its etiopathogenesis is not fully established, although traumatic and hormonal factors have been implied. Case Description A 50-year-old female patient underwent an uneventful endoscopic transsphenoidal removal of a pituitary cystic macroadenoma at our institution. Nasal packing was used in postoperative hemostasis. Histopathology was compatible with a gonadotrophin-producing adenoma. One month after the surgery, the patient presented with frequent episodes of epistaxis and a progressively growing nasal mass, which was removed endoscopically. Its pathological examination confirmed a lobular capillary hemangioma. Conclusions The authors present a clinical case combining two possible predisposing factors to the development of a nasal lobular capillary hemangioma: local traumatic injury through surgery and postoperative nasal packing and hormonal influence. This lesion is a rare complication of endoscopic transsphenoidal resections of pituitary adenomas. ; info:eu-repo/semantics/publishedVersion
العلاقة: J Neurol Surg Rep. 2017 Jan;78(1):e59-e61; http://hdl.handle.net/10400.17/2710Test
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3
المؤلفون: Carlos Pontinha, Manuela Mafra, Dalila Forte, Luís Mateus, Anabela Nabais
المصدر: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAPمصطلحات موضوعية: Adult, Pathology, medicine.medical_specialty, Neurofibromatosis 1, Ataxia, medicine.medical_treatment, Central nervous system, HIV Infections, Infratentorial Neoplasms, Astrocytoma, Neoplasms, Multiple Primary, CHLC PAT CLIN, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Neurofibromatosis, Pilocytic astrocytoma, business.industry, Supratentorial Neoplasm, Brain, Supratentorial Neoplasms, Immunosuppression, medicine.disease, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Infratentorial Neoplasm, HIV-1, Female, Surgery, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, CHLC NCIR
الوصف: BACKGROUND: Neurofibromatosis type 1 (NF1) has been identified as a predisposing factor in the development of pilocytic astrocytoma (PA), a common benign central nervous system tumor. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in nonoptic and hypothalamic locations. CASE DESCRIPTION: A 41-year-old female patient with NF1 and uncontrolled human immunodeficiency virus (HIV) type 1 infection presented with a first generalized seizure and associated headache and ataxia. Imaging studies revealed 2 large intra-axial PAs, nodular-cystic in the supratentorial compartment and solid in the infratentorial compartment. Both lesions were treated by gross total resection in 2 surgeries performed 1 week apart. Despite their different imaging patterns, the tumors were histologically and genetically identical. CONCLUSIONS: We present a unique case involving 2 histologically and genetically identical PAs occurring simultaneously in supratentorial and infratentorial locations. We suggest that an intrinsic predisposition to tumor development in patients with NF1 might have been enhanced by the HIV-related immunosuppression in this case. Strict oncologic surveillance is essential in patients with a tumor predisposition syndrome combined with immunosuppression. info:eu-repo/semantics/publishedVersion
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beebba6ea843407d70b37315e9ef6604Test
https://doi.org/10.1016/j.wneu.2018.06.011Test -
4
المؤلفون: Amets Sagarribay Irañeta, Victor Gonçalves, Anabela Nabais, António Figueiredo, Manuela Mafra, Dalila Forte
المصدر: Journal of Neurological Surgery Reports
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP
Journal of Neurological Surgery Reports, Vol 78, Iss 01, Pp e52-e54 (2017)مصطلحات موضوعية: Nasal cavity, Pyogenic Granuloma, medicine.medical_specialty, Adenoma, lcsh:Surgery, Case Report, pyogenic granuloma, lcsh:RC346-429, Benign tumor, lobular capillary hemangioma, endoscopic transsphenoidal pituitary surgery, 03 medical and health sciences, CHLC PAT CLIN, 0302 clinical medicine, Pituitary adenoma, medicine, Endoscopic Transsphenoidal Pituitary Surgery, 030223 otorhinolaryngology, lcsh:Neurology. Diseases of the nervous system, business.industry, Pyogenic granuloma, Capillary hemangioma, Lobular Capillary Hemangioma, lcsh:RD1-811, medicine.disease, Surgery, medicine.anatomical_structure, Histopathology, Neurology (clinical), business, Complication, 030217 neurology & neurosurgery, CHLC NCIR
الوصف: Background Lobular capillary hemangioma is a rare benign tumor, most frequently located in the head or neck region, the nasal cavity being uncommonly affected. Its etiopathogenesis is not fully established, although traumatic and hormonal factors have been implied. Case Description A 50-year-old female patient underwent an uneventful endoscopic transsphenoidal removal of a pituitary cystic macroadenoma at our institution. Nasal packing was used in postoperative hemostasis. Histopathology was compatible with a gonadotrophin-producing adenoma. One month after the surgery, the patient presented with frequent episodes of epistaxis and a progressively growing nasal mass, which was removed endoscopically. Its pathological examination confirmed a lobular capillary hemangioma. Conclusions The authors present a clinical case combining two possible predisposing factors to the development of a nasal lobular capillary hemangioma: local traumatic injury through surgery and postoperative nasal packing and hormonal influence. This lesion is a rare complication of endoscopic transsphenoidal resections of pituitary adenomas.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b437bd3247f4bdefa4e8602a468825Test
http://europepmc.org/articles/PMC5359141Test