Simultaneous Supratentorial and Infratentorial Pilocytic Astrocytomas in an Adult Patient with Concurrent Neurofibromatosis Type 1 and HIV Infection
| العنوان: | Simultaneous Supratentorial and Infratentorial Pilocytic Astrocytomas in an Adult Patient with Concurrent Neurofibromatosis Type 1 and HIV Infection |
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| المؤلفون: | Carlos Pontinha, Manuela Mafra, Dalila Forte, Luís Mateus, Anabela Nabais |
| المصدر: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP |
| بيانات النشر: | Elsevier BV, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Pathology, medicine.medical_specialty, Neurofibromatosis 1, Ataxia, medicine.medical_treatment, Central nervous system, HIV Infections, Infratentorial Neoplasms, Astrocytoma, Neoplasms, Multiple Primary, CHLC PAT CLIN, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Neurofibromatosis, Pilocytic astrocytoma, business.industry, Supratentorial Neoplasm, Brain, Supratentorial Neoplasms, Immunosuppression, medicine.disease, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Infratentorial Neoplasm, HIV-1, Female, Surgery, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, CHLC NCIR |
| الوصف: | BACKGROUND: Neurofibromatosis type 1 (NF1) has been identified as a predisposing factor in the development of pilocytic astrocytoma (PA), a common benign central nervous system tumor. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in nonoptic and hypothalamic locations. CASE DESCRIPTION: A 41-year-old female patient with NF1 and uncontrolled human immunodeficiency virus (HIV) type 1 infection presented with a first generalized seizure and associated headache and ataxia. Imaging studies revealed 2 large intra-axial PAs, nodular-cystic in the supratentorial compartment and solid in the infratentorial compartment. Both lesions were treated by gross total resection in 2 surgeries performed 1 week apart. Despite their different imaging patterns, the tumors were histologically and genetically identical. CONCLUSIONS: We present a unique case involving 2 histologically and genetically identical PAs occurring simultaneously in supratentorial and infratentorial locations. We suggest that an intrinsic predisposition to tumor development in patients with NF1 might have been enhanced by the HIV-related immunosuppression in this case. Strict oncologic surveillance is essential in patients with a tumor predisposition syndrome combined with immunosuppression. info:eu-repo/semantics/publishedVersion |
| تدمد: | 1878-8750 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beebba6ea843407d70b37315e9ef6604Test https://doi.org/10.1016/j.wneu.2018.06.011Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....beebba6ea843407d70b37315e9ef6604 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18788750 |
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