دورية أكاديمية
Higher rates of t(11;18) in Chinese patients with transformed type of MALT lymphoma suggest novel pathways for progression of the disease
| العنوان: | Higher rates of t(11;18) in Chinese patients with transformed type of MALT lymphoma suggest novel pathways for progression of the disease |
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| المؤلفون: | Ke, Xiaoyan, Zhao, Linzhi, Gao, Zifen, Wang, Jing, Dong, Fei, Zhou, Xiaoge, Shi, Lin, Huang, Xuebiao, Jing, Hongmei, Wang, Jijun, Zhao, Wei, Yang, Xiao-Feng |
| المساهمون: | Ke, XY (reprint author), Peking Univ, Third Hosp, Dept Hematol, Peking Univ Hlth Sci Ctr, Beijing 100083, Peoples R China., Peking Univ, Third Hosp, Dept Hematol, Peking Univ Hlth Sci Ctr, Beijing 100083, Peoples R China., Peking Univ, Third Hosp, Lymphoma Res Ctr, Peking Univ Hlth Sci Ctr, Beijing 100083, Peoples R China., Peking Univ, Third Hosp, Dept Pathol, Peking Univ Hlth Sci Ctr, Beijing 100083, Peoples R China., Beijing Youyi Hos, Dept Pathol, Beijing, Peoples R China., Peking Univ, Third Hosp, Dept Gastroenterol Dis, Peking Univ Hlth Sci Ctr, Beijing 100083, Peoples R China., Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19122 USA. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | leukemia lymphoma |
| سنة النشر: | 2007 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | MALT lymphoma, chromosomal translocation t(11, 18), BCL-10 expression, Chinese patients, anti-H.-pylori therapy, B-CELL LYMPHOMA, HELICOBACTER-PYLORI, TISSUE LYMPHOMA, BCL10, GENE, T(11/18)(Q21,Q21), T(1/14)(P22,Q32), CLASSIFICATION, TRANSLOCATION, ERADICATION |
| الوصف: | To detect the t(11; 18) chromosome translocation in different stages of mucosa-associated lymphoid tissue (MALT) lymphoma, we established a RT-PCR method by adopting three new primer pairs and using the RNA extracted from the paraffin tissues to amplify the t(11; 18) fusion gene API2-MALT1 in shorter lengths. Our results showed five key findings, which are (a) higher detection rates of t(11; 18) (21.13%) in Chinese patients with transformed MALT lymphoma, (b) lower detection rates of t(11; 18) in stomach MALT lymphoma, (c) different organ localizations of MALT lymphoma in Chinese patients, (d) higher nuclear expression rates of Bcl-10 in low grade MALT (51.72%), and (e) lower response rates (50% CR, and 50% PR) to anti -H.-pylori therapy. These findings suggest novel pathways for low-grade MALT lymphoma to be progressed into transformed MALT lymphoma. This study also suggests that amplification of shorter length of PCR products from the paraffin-fixed tissues increases sensitivity, which is significant in improving the selection of the therapeutic regimen and assessing the prognosis of the disease. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000250839100013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Oncology ; Hematology ; SCI(E) ; PubMed ; 3 ; ARTICLE ; 11 ; 2157-2166 ; 48 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1042-8194 |
| العلاقة: | LEUKEMIA & LYMPHOMA.2007,48,(11),2157-2166.; 673211; http://hdl.handle.net/20.500.11897/198094Test; WOS:000250839100013 |
| DOI: | 10.1080/10428190701606818 |
| الإتاحة: | https://doi.org/20.500.11897/198094Test https://doi.org/10.1080/10428190701606818Test https://hdl.handle.net/20.500.11897/198094Test |
| رقم الانضمام: | edsbas.A2B7E496 |
| قاعدة البيانات: | BASE |
| تدمد: | 10428194 |
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| DOI: | 10.1080/10428190701606818 |