التفاصيل البيبلوغرافية
| العنوان: |
Immunomodulatory Effect of Chinese Herbal Medicine Formula Sheng-Fei-Yu-Chuan-Tang in Lipopolysaccharide-Induced Acute Lung Injury Mice. |
| المؤلفون: |
Chia-Hung Lin1, Ching-Hua Yeh2, Li-Jen Lin3, Shulhn-Der Wang4, Jen-Shu Wang5,6 wang0826@tzuchi.com.tw, Shung-Te Kao1,7 stkao@mail.cmu.edu.tw |
| المصدر: |
Evidence-based Complementary & Alternative Medicine (eCAM). 2013, Vol. 2013, p1-12. 12p. 2 Charts, 6 Graphs. |
| مصطلحات موضوعية: |
*LUNG disease treatment, *REACTIVE oxygen species, *ANIMAL experimentation, *CYTOKINES, *FREE radicals, *CHINESE medicine, *MICE, *POLYMERASE chain reaction, *PROBABILITY theory, *RESEARCH funding, *TUMOR necrosis factors, *WESTERN immunoblotting, *DATA analysis software |
| مصطلحات جغرافية: |
TAIWAN |
| مستخلص: |
Traditional Chinese medicine formula Sheng-Fei-Yu-Chuan-Tang (SFYCT), consisting of 13 medicinal plants, was used to treat patients with lung diseases. This study investigated the immunoregulatory effect of SFYCT on intratracheal lipopolysaccharides-(LPS-) challenged acute lung injury (ALI) mice. SFYCT attenuated pulmonary edema, macrophages, and neutrophils infiltration in the airways. SFYCT decreased inflammatory cytokines, including tumor necrosis factor-α (TNFα), interleukin-1β, and interleukin-6 and inhibited nitric oxide (NO) production but increased anti-inflammatory cytokines, interleukin-4, and interleukin-10, in the bronchoalveolar lavage fluid of LPS-challenged mice. TNFα and monocyte chemotactic protein-1 mRNA expression in the lung of LPS-challenged mice as well as LPS-stimulated lung epithelial cell and macrophage were decreased by SFYCT treatment. SFYCT treatment also decreased the inducible nitric oxide synthase expression and phosphorylation of nuclear factor-κB (NF-κB) in the lung of mice and macrophage with LPS stimulation. SFYCT treatment dose dependently decreased the LPS-induced NO and reactive oxygen species generation in LPS-stimulated macrophage. In conclusion, SFYCT attenuated lung inflammation during LPS-induced ALI through decreasing inflammatory cytokines production while increasing anti-inflammatory cytokines production. The immunoregulatory effect of SFYCT is related to inhibiting NF-κB phosphorylation. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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