التفاصيل البيبلوغرافية
| العنوان: |
Use of medication for attention‐deficit/hyperactivity disorder and risk of unintentional injuries in children and adolescents with co‐occurring neurodevelopmental disorders. |
| المؤلفون: |
Ghirardi, Laura, Chen, Qi, Chang, Zheng, Kuja‐Halkola, Ralf, Skoglund, Charlotte, Quinn, Patrick D., D'Onofrio, Brian M., Larsson, Henrik |
| المصدر: |
Journal of Child Psychology; Feb2020, Vol. 61 Issue 2, p140-147, 8p, 5 Charts |
| مصطلحات موضوعية: |
ATTENTION-deficit hyperactivity disorder, BRAIN injuries, CHILDREN'S injuries, CONFIDENCE intervals, DEVELOPMENTAL disabilities, RISK assessment, WOUNDS & injuries, PROPORTIONAL hazards models, DESCRIPTIVE statistics, DISEASE risk factors |
| مصطلحات جغرافية: |
SWEDEN |
| مستخلص: |
Background: Attention‐deficit/hyperactivity disorder (ADHD) is often associated with other neurodevelopmental disorders (NDs) and with risky behaviors and adverse health outcomes, including injuries. Treatment with ADHD medication has been associated with reduced risk of injuries. However, it is unknown whether the association is present in individuals with co‐occurring NDs. The aim of the present study was to estimate the association between ADHD medication use and unintentional injuries in Sweden in children and adolescents with ADHD, including those with co‐occurring NDs. Methods: Using a linkage of several national registers via the unique personal identification number, we identified individuals with a diagnosis of ADHD and of other NDs, including autism spectrum disorder, intellectual disability, communication disorders, learning disorders and motor disorders. The primary outcome was unintentional injuries. Secondary outcome was traumatic brain injury (TBI). Individuals were followed from January 1st 2006 or their 5th birthday or the date of the first unintentional injury, whichever came last, to December 31st 2013 or their 18th birthday or death, whichever came first. We compared the rate of injuries during periods on‐treatment with the rate of injuries during periods off‐treatment within the same individual using stratified Cox regression to calculate hazard ratio (HR) with 95% confidence intervals (CIs). Results: For children and adolescents with ADHD (N = 9,421) the rate of any unintentional injuries (HR = 0.85; 95% CI = 0.78–0.92) and TBIs (HR = 0.27; 95% CIs = 0.20–0.38) during medicated periods was lower than during non‐medicated periods. Similar results were found among individuals with co‐occurring NDs (N = 2,986), for unintentional injuries (HR = 0.88; 95% CI = 0.77–1.01) and for TBIs (HR = 0.27; 95% CI = 0.16–0.44). Conclusions: Beneficial effects of ADHD medication may extend beyond reduction of ADHD core symptoms to prevention of unintentional injuries in children and adolescents, including individuals with co‐occurring NDs. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Child Psychology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
