التفاصيل البيبلوغرافية
| العنوان: |
Off-Label Drug Use in Pediatric Out-Patient Care: A Multi-Center Observational Study. |
| المؤلفون: |
AlAzmi, Aeshah1,2,3 aeshah.alazmi@gmail.com, Alasmari, Zahra1,4, Yousef, Consuela5, Alenazi, Ahmed5, AlOtaibi, Mohammed1, AlSaedi, Hani1, AlShaikh, Adnan1,6, AlObathani, Amani1, Ahmed, Omaima1,2, Goronfolah, Loie1, Alahmari, Mousa1 |
| المصدر: |
Hospital Pharmacy. Dec2021, Vol. 56 Issue 6, p690-696. 7p. |
| مصطلحات موضوعية: |
*RESEARCH, *SCIENTIFIC observation, *CHILDREN'S hospitals, *AGE distribution, *RETROSPECTIVE studies, *ANTI-infective agents, *MEDICAL cooperation, *SEX distribution, *DRUG prescribing, *DESCRIPTIVE statistics, *PHYSICIAN practice patterns, *STATISTICAL sampling, *OUTPATIENT services in hospitals, *OFF-label use (Drugs) |
| مصطلحات جغرافية: |
SAUDI Arabia |
| مستخلص: |
Objective: Prescribing a drug for a child is not an easy task and requires using the best available evidence as a guide, especially when a drug is used off-label. The practice of prescribing a drug for off-label use is fairly widespread worldwide. The FDA does not regulate prescribing patterns or practices of individual practitioners and, therefore, allows off-label use. The main objective of this study is to evaluate off-label prescribing among the pediatric population in the Kingdom of Saudi Arabia (KSA). Method: This is a retrospective, simple random selection observational study of children (≤15 years) who visited pediatric clinics and had at least 1 drug prescribed over a 12-month period (January to December 2018). Results: A total of 865 drugs (mean 1 and SD 0.24) were prescribed to 326 children. Off-label was identified in 39.4% of the drugs with a frequency of 512 (as 1 drug may belong to more than 1 off-label category). The most common reason for off-label prescribing was related to doses that were "higher or lower than the recommended use" (48.6%), and the most frequently identified drug class prescribed for off-label use was anti-infective drugs for systemic use (39.9%). The percentage of off-label drug use was found to be higher in girls and in the age group of 1 month to 2 years (P =.001) for both variables. In addition, a significant association was found between off label drug use and the total number of drugs prescribed, P <.001. Conclusion: The findings of this study showed a high incidence of off-label prescribing mainly related to dosing and indication. The results of this observational study support the need to establish a unified national pediatric dosing formulary guide to ensure safe drug use in pediatrics. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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