Lipids methabolism and antioxidant status in exogenous constitutional obesity in girls of Buryatia
| العنوان: | Lipids methabolism and antioxidant status in exogenous constitutional obesity in girls of Buryatia |
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| المؤلفون: | L. I. Kolesnikova, M. A. Darenskaya, L. V. Rychkova, L. A. Grebenkina, N. V. Semenova, S. I. Kolesnikov |
| المصدر: | Rossijskij Vestnik Perinatologii i Pediatrii, Vol 66, Iss 1, Pp 80-86 (2021) |
| بيانات النشر: | Ltd. “The National Academy of Pediatric Science and Innovation”, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Very low-density lipoprotein, obesity, Physiology, Disease, Mongoloid, Pediatrics, RJ1-570, lipids, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, buryatia, children, Medicine, business.industry, Cholesterol, Incidence (epidemiology), girls, medicine.disease, Obesity, 030104 developmental biology, antioxidants, chemistry, Pediatrics, Perinatology and Child Health, business, 030217 neurology & neurosurgery, Dyslipidemia |
| الوصف: | The study of adolescent obesity and pathogenic factors of its development is getting more and more important as the disease aggravates in adulthood. The serious progress in the study of the pathogenesis of this process can be achieved by analyzing the molecular mechanisms of the obesity development in childhood and adolescence. An individual approach to the diagnosis and treatment of obesity includes various factors, including the patient’s nationality. In recent decades there is an increase in the incidence of obesity among the representatives of the Mongoloid race, which is not characteristic of this racial group. Thus, the aim of the study was to analyze the state of lipid metabolism and the level of antioxidant components in the Buryat girls with exogenous constitutional obesity of the 1st degree. The authors examined 44 girls with exogenous constitutional obesity of the 1st degree and 48 practically healthy adolescent girls (comparison group) of the same age. All the girls belonged to the Buryat ethnic group. They used spectrophotometric and fluorometric research methods. The study revealed that exogenous constitutional obesity in adolescent girls is accompanied by the development of dyslipidemia (increased concentrations of total cholesterol, triacylglycerols, very low density lipoprotein cholesterol, an increase in the atherogenic coefficient, a decreased level of high density lipoprotein cholesterol), as well as a deficiency of antioxidant defense components (decreased levels α-tocopherol, retinol, activity of superoxide dismutase and glutathione-S-transferase). These results expand the understanding of the pathophysiological mechanisms of adolescent obesity and develop individual approaches to the treatment of this condition. |
| اللغة: | Russian |
| تدمد: | 2500-2228 1027-4065 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbb3a2dcde9e4ccc13dae658571ea99Test https://www.ped-perinatology.ru/jour/article/view/1342Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0cbb3a2dcde9e4ccc13dae658571ea99 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25002228 10274065 |
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