المؤلفون: Feduniw, Stepan¹ (AUTHOR), Krupa, Izabela² (AUTHOR), Łagowska, Katarzyna² (AUTHOR), Laudański, Piotr^3,4,5 (AUTHOR), Tabarkiewicz, Jacek^2,6 (AUTHOR), Stawarz, Barbara⁷ (AUTHOR), Raba, Grzegorz⁸ (AUTHOR)

المصدر: Journal of Pregnancy. 5/7/2024, Vol. 2024, p1-10. 10p.

مصطلحات موضوعية: *CANNABINOID receptors, *PREMATURE labor, *PLACENTA, *GENETIC transcription, *CHILDBIRTH

مستخلص: Background: The cannabinoid receptor (CBR) plays a significant role in oogenesis, pregnancy, and childbirth. It might also play a significant role in preterm birth (PTB). The aim of the study was to investigate the association between the expression of the CBR in the placenta and the incidence of PTB. Methods: This prospective, observational, multicentre preliminary study was conducted on placental samples obtained from 109 women. The study included 95 patients hospitalized due to the high risk of PTB. They were divided into two groups: Group 1, where the expression of the CBR1 and CBR1a was analyzed, and Group 2, in which we examined CBR2 expression. The control group, that is, Group 3, consisted of 14 women who delivered at term, and their placentas were tested for the presence of all three receptor types (CBR1, CBR1a, and CBR2). Results: The study used reverse transcription and real-time PCR methods to assess the expression of CBRs in the placental tissues. The expression of the CBR2, CBR1, and CBR1a receptors was significantly lower in the placentas of women after PTB compared to those after term births, p = 0.038 , 0.033, and 0.034, respectively. Conclusions: The presence of CBR mRNA in the human placental tissue was confirmed. The decreased expression of CBRs could serve as an indicator in predicting PTB. [ABSTRACT FROM AUTHOR]

المؤلفون: Qin, Wei^1,2 (AUTHOR), Shao, Ling^1,3 (AUTHOR), Wang, Jun² (AUTHOR), Zhang, Huan² (AUTHOR), Wang, Yao² (AUTHOR), Zhang, Xiaqing^2,4 (AUTHOR), Xie, Shaoyu² (AUTHOR), Pan, Fan² (AUTHOR), Cheng, Kai² (AUTHOR), Ma, Liguo² (AUTHOR), Chen, Yafei² (AUTHOR), Song, Jian¹ (AUTHOR), Gao, Dawei⁵ (AUTHOR), Chen, Zhichao⁵ (AUTHOR), Yang, Wei⁵ (AUTHOR), Zhu, Rui⁵ (AUTHOR), Su, Hong¹ (AUTHOR) suhong5151@sina.com

المصدر: Journal of Viral Hepatitis. Mar2024, Vol. 31 Issue 3, p143-150. 8p.

مصطلحات موضوعية: *PREMATURE labor, *LOW birth weight, *HEPATITIS B vaccines, *CHILDBIRTH, *PREMATURE infants, *BOOSTER vaccines

مستخلص: Previous studies did not provide substantial evidence for long‐term immune persistence after the hepatitis B vaccine (HepB) in preterm birth (PTB) children. Consequently, there is ongoing controversy surrounding the booster immunization strategy for these children. Therefore, we conducted a retrospective cohort study to evaluate the disparities in immune persistence between PTB children and full‐term children. A total of 1027 participants were enrolled in this study, including 505 PTB children in the exposure group and 522 full‐term children in the control group. The negative rate of hepatitis B surface antibody (HBsAb) in the PTB group was significantly lower than that in the control group (47.9% vs. 41.4%, p =.035). The risk of HBsAb‐negative in the exposure group was 1.5 times higher than that in the control group (adjusted odds ratio [aOR] = 1.5, 95% confidence interval [CI]: 1.1–2.0). The geometric mean concentration (GMC) of HBsAb was much lower for participants in the exposure group compared to participants in the control group (9.3 vs. 12.4 mIU/mL, p =.029). Subgroup analysis showed that the very preterm infants (gestational age <32 weeks) and the preterm low birth weight infants (birth weight <2000 g) had relatively low GMC levels of 3.2 mIU/mL (95% CI: 0.9–11.1) and 7.9 mIU/mL (95% CI: 4.2–14.8), respectively. Our findings demonstrated that PTB had a significant impact on the long‐term persistence of HBsAb after HepB vaccination. The very preterm infants (gestational age <32 weeks) and the preterm low birth weight infants (birth weight <2000 g) may be special populations that should be given priority for HepB booster vaccination. [ABSTRACT FROM AUTHOR]

المؤلفون: Spaegele, Nina¹ (AUTHOR), Ditzer, Julia^1,2 (AUTHOR) julia.ditzer@gmail.com, Rodrigues, Mariana¹ (AUTHOR), Talmon, Anat^1,3 (AUTHOR) atalmon@mail.huji.ac.il

المصدر: BMC Pregnancy & Childbirth. 2/5/2024, Vol. 24 Issue 1, p1-10. 10p.

مصطلحات موضوعية: *PREMATURE labor, *SOMATIC sensation, *SELF-presentation, *PREGNANT women, *DOULAS, *INFANT mortality

مستخلص: Background: Preterm birth, which occurs when a baby is born before 37 weeks, has enormous implications for public health. It is the leading cause of infant death and mortality in children under the age of five. Unfortunately, the multifaceted causes of preterm birth are not fully understood. One construct that has received increasing attention in women's transition to motherhood is body boundaries, i.e., the metaphorical barriers that separate the self from the outer, surrounding "not self." This study aims to examine the role of well-defined and disturbed body boundaries in predicting preterm birth. Methods: A sample of 655 Israeli pregnant women reported their sense of body boundaries (BBS, as measured by the Sense of Body Boundaries Survey) pre- and postnatally. We performed a General Linear Model (GLM) testing the effect of the BBS total score on the days women delivered before their due date and controlling for whether it was the women's first child. Results: Our GLMs controlling for whether it was the women's first child showed that the BBS total mean exhibited a significant predictive effect on the number of days delivered before the due date (F(57,313) = 3.65, p <.001). Conclusions: These results demonstrate heterogeneity in women's sense of body boundaries during pregnancy and are the first to disentangle a link between disturbed body boundaries and preterm birth. Mediating mechanisms in this relation, e.g., psychosocial stress, as well as clinical implications are discussed in detail. [ABSTRACT FROM AUTHOR]

المؤلفون: Pambet, Mathilde¹ (AUTHOR), Sirodot, Fanny¹ (AUTHOR), Pereira, Bruno² (AUTHOR), Cahierc, Romain¹ (AUTHOR), Delabaere, Amélie^1,3 (AUTHOR), Comptour, Aurélie¹ (AUTHOR), Rouzaire, Marion¹ (AUTHOR), Sapin, Vincent^4,5 (AUTHOR), Gallot, Denis^1,5 (AUTHOR) dgallot@chu-clermontferrand.fr

المصدر: Journal of Clinical Medicine. Sep2023, Vol. 12 Issue 17, p5707. 11p.

مصطلحات موضوعية: *PREMATURE labor, *CHILDBIRTH, *UNIVERSITY hospitals, *FIBRONECTINS, *LONGITUDINAL method

مصطلحات جغرافية: CLERMONT-Ferrand (France)

مستخلص: We conducted a prospective double-blind study to compare two vaginal diagnostic methods in singleton pregnancies with threatened preterm labor (TPL) at the University Hospital of Clermont-Ferrand (France) from August 2018 to December 2020. Our main objective was to compare the diagnostic capacity at admission, in terms of positive predictive value (PPV) and negative predictive value (NPV), of Premaquick® (combined detection of IL-6/total IGFBP-1/native IGFBP-1) and QuikCheck fFN™ (fetal fibronectin) for delivery within 7 days in cases of TPL. We included 193 patients. Premaquick® had a sensitivity close to 89%, equivalent to QuikCheck fFN™, but a higher statistical specificity of 49.5% against 38.6% for QuikCheck fFN™. We found no superiority of Premaquick® over QuickCheck fFN™ in terms of PPV (6.6% vs. 7.9%), with NPV being equivalent in predicting childbirth within 7 days in cases of TPL (98.6% vs. 98.9%). Nevertheless, the combination of positive native and total IGFBP-1 and the combination of all three positive markers were associated with a higher PPV. Our results, though non-significant, support this combined multiple-biomarker approach to improve testing in terms of predictive values. [ABSTRACT FROM AUTHOR]

المؤلفون: Husby, Anne Engtrø, Simpson, Melanie Rae, Dalbye, Rebecka, Larsen, Marit, Vanky, Eszter, Løvvik, Tone Shetelig

المصدر: Acta Obstetricia et Gynecologica Scandinavica; Jun2024, Vol. 103 Issue 6, p1092-1100, 9p

مصطلحات موضوعية: POLYCYSTIC ovary syndrome, CHILDBIRTH, PREMATURE labor, PREGNANCY complications, PREGNANCY outcomes, LABOR complications (Obstetrics)

مصطلحات جغرافية: ICELAND, NORWAY, SWEDEN

مستخلص: Introduction: Women with polycystic ovary syndrome (PCOS) have more pregnancy complications like gestational diabetes, hypertension, and preterm labor than other women. Metformin has been used in an attempt to improve pregnancy outcomes. Our study aims to explore childbirth experiences in women with PCOS compared with a reference population. It also explores the potential influence of metformin, obesity, pregnancy complications, and the duration and mode of birth on childbirth experiences. Material and methods: This study is a cohort study combining data from two randomized trials conducted in Norway, Sweden and Iceland. The PregMet2 study (ClinicalTrials.gov, NCT01587378) investigated the use of metformin vs. placebo in pregnant women with PCOS. The Labour Progression Study (ClinicalTrials.gov, NCT02221427) compared the WHO partograph to Zhang's guidelines for progression of labor and were used as the reference population. A total of 365 women with PCOS and 3604 reference women were included. Both studies used the Childbirth Experience Questionnaire (CEQ). Main outcome measures were total CEQ score and four domain scores. The CEQ scores were compared using Mann–Whitney U test for women in Robson group 1 with PCOS (n = 131) and reference women (n = 3604). CEQ scores were also compared between metformin‐treated (n = 180) and placebo‐treated (n = 185) women with PCOS, and for different subgroups of women with PCOS. Results: There was no difference in total CEQ score between women with PCOS and reference women—Wilcoxon–Mann–Whitney (WMW)‐odds 0.96 (95% confidence interval [CI] 0.78–1.17). We detected no difference in CEQ scores between the metformin‐ and placebo‐treated women with PCOS (WMW‐odds 1.13, 95% CI 0.89–1.43). Complications in pregnancy did not affect CEQ (WMW‐odds 1, 95% CI 0.76–1.31). Higher body mass index (WMW‐odds 0.75, 95% CI 0.58–0.96), longer duration of labor (WMW‐odds 0.69, 95% CI 0.49–0.96), and cesarean section (WMW‐odds 0.29, 95% CI 0.2–0.42) were associated with lower CEQ scores in women with PCOS. Conclusions: Women with PCOS experience childbirth similarly to the reference women. Metformin did not influence childbirth experience in women with PCOS, neither did pregnancy complications. Obesity, long duration of labor or cesarean section had a negative impact on childbirth experience. [ABSTRACT FROM AUTHOR]

: Copyright of Acta Obstetricia et Gynecologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Ribeiro, Reitan¹ (AUTHOR) reitanribeiro@hotmail.com, Anselmi, Maria Cristina² (AUTHOR), Schneider, Gunther Alex³ (AUTHOR), Rodrigues Furtado, José Pio⁴ (AUTHOR), Mohamed Abau Shwareb, Mohamed Gaber³ (AUTHOR), Linhares, José Clemente¹ (AUTHOR)

المصدر: Fertility & Sterility. Jul2023, Vol. 120 Issue 1, p188-193. 6p.

مصطلحات موضوعية: *PREMATURE labor, *CHILDBIRTH, *CESAREAN section, *CANCER hospitals, *APGAR score, *LIPOSARCOMA

الملخص (بالإنجليزية): To our knowledge, to report the first case of live birth of a child after uterine transposition (UT), pelvic radiotherapy, and subsequent uterine repositioning. Case report. Tertiary referral cancer hospital. A 28-year-old nulligravid woman with left iliac and thoracic synchronous myxoid low-grade liposarcoma, which was resected with close margins. The patient underwent UT before undergoing pelvic (60 Gy) and thoracic (60 Gy) radiation on October 25, 2018. After radiotherapy, her uterus was reimplanted in the pelvis on February 20, 2019. The patient became pregnant in June 2021 and experienced an uneventful pregnancy until 36 weeks, when the patient started preterm labor and had a cesarean section delivery on January 26, 2022. A boy was delivered after a gestation period of 36 weeks and 2 days (2686 g and 46.5 cm), with Apgar scores of 5 and 9, respectively; both mother and child were discharged the following day. After 1 year of follow-ups, the infant maintained normal development and the patient showed no signs of recurrence. To our knowledge, this case of the first live birth after UT is a proof-of-concept for the viability of UT as a procedure to prevent infertility in patients requiring pelvic radiotherapy. [ABSTRACT FROM AUTHOR]

Abstract (Spanish): Primer nacido vivo tras transposición uterina Hasta donde sabemos, reportar el primer caso de nacido vivo de un niño tras transposición uterina (UT), radioterapia pélvica y posterior reposicionamiento uterino. Caso de estudio. Hospital oncológico terciario de referencia. Mujer de 28 años nuligesta, con liposarcoma mixoide de bajo grado sincrónico torácico e ilíaco izquierdo, que fue extirpado con márgenes estrechos. La paciente fue sometida a UT antes de recibir radioterapia pélvica (60Gy) y torácica (60Gy) el 25 de octubre de 2018. Tras la radioterapia, su útero fue reimplantado en la pelvis el 20 de febrero de 2019. La paciente resultó embarazada en junio de 2021 y experimentó una gestación sin incidentes hasta las 36 semanas, cuando la paciente inició trabajo de parto prematuro y tuvo un parto por cesárea el 26 de enero de 2022. Un niño nació tras de un período de gestación de 36 semanas y 2 días (2686 g y 46,5 cm), con puntuaciones de Apgar de 5 y 9, respectivamente; tanto la madre como el niño fueron dados de alta al día siguiente. Después de 1 año de seguimiento, el bebé mantuvo un desarrollo normal y la paciente no mostró signos de recurrencia. Para nuestro conocimiento. Este primer caso de recién nacido vivo tras UT es una prueba de concepto para la viabilidad del UTcomo procedimiento para prevenir la infertilidad en pacientes que requieran radioterapia pélvica. [ABSTRACT FROM AUTHOR]

المؤلفون: Abuduxike, Gulifeiya, Cali, Sanda, Vaizoğlu, Songül Acar, Aşut, Özen, Çavuş, Mahmut, Olgu, Musa, Çavuş, Simay Naime, Arkut, Meryem, Idehen, Blessing Oluwaseun, Almezghwi, Heyam Abdalla Saleh, Asswayeh, Hana Muftah Ali, Abawu, Janet James, Hossain, Mohammad Jayed, Almawali, Nusaiba AbdulMunaem

المصدر: Maternal & Child Health Journal; Apr2024, Vol. 28 Issue 4, p667-678, 12p

مصطلحات موضوعية: CESAREAN section, RISK assessment, PUBLIC hospitals, DELIVERY (Obstetrics), VAGINA, CYPRIOTS, SCIENTIFIC observation, PREMATURE infants, RETROSPECTIVE studies, DESCRIPTIVE statistics, CHI-squared test, AGE distribution, BIRTH rate, RESEARCH methodology, MEDICAL records, ACQUISITION of data, DATA quality, COMPARATIVE studies, DATA analysis software, TURKISH Cypriots, PREGNANCY complications, CHILDBIRTH, FETAL presentation, PREMATURE labor

مصطلحات جغرافية: ISLANDS of the Mediterranean

مستخلص: Objective: We aimed to understand the utilization of the mode of delivery and related risk factors. Further aimed to apply the Robson classification system to evaluate the data quality and analyze the CS rates in subgroups. Methods: We conducted a retrospective descriptive study by reviewing the medical records of all women who delivered at the State Hospital in 2019. A proforma was developed for extracting data from patient records. All women with six obstetric parameters were categorized into Robson groups to determine the absolute and relative contributions of each group to the overall CS rate. Results: Of 797 deliveries, 401 (50.2%) were CSs. Being older, being Turkish Cypriot, having preterm births, previous CS, multiple fetuses, and having breech or transverse fetal presentations were related to having higher risks of CS. The most common medical indication for CSs (52.3%) was a history of previous CSs. Robson Group 5 contributed the most (50.7%) to the overall CS rate, with the highest absolute contribution of 21.8%. Group 10 and Group 8 were the second and third highest contributors to the overall CS rate, with relative contributions of 25.3% and 9.0%, respectively. Conclusions: Findings revealed the substandard quality of obstetric data and a noticeably high overall CS rate. The top priority should be given to improving the quality of medical records. It underscored the necessity of implementing the Robson classification system as a standard clinical practice to enhance data quality, which helps to effectively evaluate and monitor the CS rates in obstetric populations. Significance: Caesarean section rates are increasing worldwide, and the Robson Classification System is recommended by the WHO to evaluate and monitor the CS rates. This study is the first to use Robson classifications and revealed high CS rates in specific subgroups of the obstetric population. The inadequate, substandard data quality highlighted the areas that urgently needed improvement in clinical practices at the largest state hospital. The study lays the foundation for further nationwide studies and demonstrates the importance of the Robson classification system. Specific recommendations were provided to the hospital management for improving the quality of the obstetric data and monitoring CS rates. [ABSTRACT FROM AUTHOR]

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المؤلفون: Flis, Wojciech, Socha, Maciej W.

المصدر: Cells (2073-4409); Apr2024, Vol. 13 Issue 7, p600, 22p

مصطلحات موضوعية: FRUIT ripening, NLRP3 protein, CHILDBIRTH, INFLAMMASOMES, PREMATURE labor, CERVIX uteri, INFLAMMATORY mediators

مستخلص: The uterine cervix is one of the key factors involved in ensuring a proper track of gestation and labor. At the end of the gestational period, the cervix undergoes extensive changes, which can be summarized as a transformation from a non-favorable cervix to one that is soft and prone to dilation. During a process called cervical ripening, fundamental remodeling of the cervical extracellular matrix (ECM) occurs. The cervical ripening process is a derivative of many interlocking and mutually driving biochemical and molecular pathways under the strict control of mediators such as inflammatory cytokines, nitric oxide, prostaglandins, and reactive oxygen species. A thorough understanding of all these pathways and learning about possible triggering factors will allow us to develop new, better treatment algorithms and therapeutic goals that could protect women from both dysfunctional childbirth and premature birth. This review aims to present the possible role of the NLRP3 inflammasome in the cervical ripening process, emphasizing possible mechanisms of action and regulatory factors. [ABSTRACT FROM AUTHOR]

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المؤلفون: Suarez, Anna, Yakupova, Vera

المصدر: BMC Pregnancy & Childbirth; 3/11/2024, Vol. 24 Issue 1, p1-11, 11p

مصطلحات موضوعية: CHILD abuse, CHILDBIRTH, PREMATURE labor, RUSSIANS, PREGNANCY complications

مستخلص: Background: A substantial number of women who subsequently become pregnant and give birth have a history of physical, sexual, and/or child abuse. This study investigated the associations of these types of traumas and their cumulative effect with childbirth experiences, namely, mode of birth, maternal and child complications during pregnancy/childbirth, preterm birth, medical procedures, and obstetric violence during labour. Methods: A group of Russian women (n = 2,575) who gave birth within the previous 12 months, completed a web-based survey, where they provided demographic information, details about their childbirth experiences, and a history of trauma. Results: Women with any type of past abuse were at higher risk for maternal complications during pregnancy/childbirth (exp(β) < 0.73, p < 0.010 for all). More specific to the type of trauma were associations of physical abuse with caesarean birth, child abuse with complications during pregnancy/childbirth for the baby, and physical and child abuse with obstetric violence (exp(β) < 0.54, p < 0.022 for all). There was a cumulative effect of trauma for all the outcomes except for medical procedures during childbirth and preterm birth. Conclusion: This study provides insights into potential different individual effects of physical, sexual, and/or child abuse as well as their cumulative impact on the childbirth experiences. The robust findings about maternal complications during pregnancy/childbirth and obstetric violence highlight the importance of trauma-informed care, supportive policies, and interventions to create safe and empowering birthing environments that prioritise patient autonomy, dignity, and respectful communication. [ABSTRACT FROM AUTHOR]

: Copyright of BMC Pregnancy & Childbirth is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Adamczak, Ada Maria, Werblińska, Alicja, Jamka, Małgorzata, Walkowiak, Jarosław

المصدر: Biomedicines; Mar2024, Vol. 12 Issue 3, p490, 19p

مصطلحات موضوعية: GUT microbiome, PREMATURE labor, HUMAN microbiota, CHILDREN'S health

مستخلص: In recent years, the number of scientific publications on the role of intestinal microbiota in shaping human health, as well as the occurrence of intestinal dysbiosis in various disease entities, has increased dynamically. However, there is a gap in comprehensively understanding the factors influencing a child's gut microbiota. This review discusses the establishment of gut microbiota and the immunological mechanisms regulating children's microbiota, emphasising the importance of prioritising the development of appropriate gut microbiota in a child from the planning stages of pregnancy. The databases PubMed, Web of Sciences, Cochrane, Scopus and Google Scholar were searched to identify relevant articles. A child's gut microbiota composition is influenced by numerous factors, such as diet during pregnancy, antibiotic therapy, the mother's vaginal microbiota, delivery method, and, later, feeding method and environmental factors. During pregnancy, the foetus naturally acquires bacterial strains from the mother through the placenta, thereby shaping the newborn's immune system. Inappropriate maternal vaginal microbiota may increase the risk of preterm birth. Formula-fed infants typically exhibit a more diverse microbiota than their breastfed counterparts. These factors, among others, shape the maturation of the child's immune system, impacting the production of IgA antibodies that are central to cellular humoral immune defence. Further research should focus on identifying specific microbiota–immune system interactions influencing a child's immune health and developing personalised treatment strategies for immune-related disorders. [ABSTRACT FROM AUTHOR]

: Copyright of Biomedicines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)