المؤلفون: Tanghöj, Gustaf, Naumburg, Estelle

المصدر: Scientific Reports; 2/27/2024, Vol. 14 Issue 1, p1-6, 6p

مصطلحات موضوعية: ATRIAL septal defects, CONGENITAL heart disease, PREMATURE labor, CHILDBIRTH, HEART failure, DOWN syndrome

مصطلحات جغرافية: SWEDEN

مستخلص: Atrial septal defect secundum is a common type of congenital heart defect and even more common among children born premature. The aim of this study was to assess premature birth as a potential associated risk factors for cardiac morbidity in children with isolated ASD II. In this retrospective national registry-based case–control study all children born in Sweden between 2010 and 2015 with an isolated ASD II diagnosis were included. Association between premature birth and cardiac morbidity in children with isolated ASD II was assessed by different outcomes-models using conditional logistic regression and adjustments were made for confounding factors. Overall, 11% of children with an isolated ASD II received treatment for heart failure. Down syndrome was the only independent risk factors for associated with cardiac morbidity in children with ASD II (OR = 2.25 (95%CI 1.25–4.07). Preterm birth in children was not associated with an increased risk of ASD II cardiac morbidity. [ABSTRACT FROM AUTHOR]

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المؤلفون: Sassa, Miho, Kinoshita, Ryo, Murano, Yayoi, Shoji, Hiromichi, Yoneoka, Daisuke

المصدر: PLoS ONE; 2/14/2024, Vol. 19 Issue 2, p1-5, 5p

مصطلحات موضوعية: BIRTH certificates, CHILDBIRTH, PREMATURE labor, HOLIDAYS, BIRTH weight

مصطلحات جغرافية: JAPAN

مستخلص: Maternity and neonatal services always have to operate 24 hours a day and 7 days a week, and require well preparedness to guarantee safe deliveries for both mothers and babies. However, the evidence of holiday effect from large-scale data is still insufficient from the obstetrics perspective. We analyzed data of over 21 million births in Japan from January 1, 1979, to December 31, 2018. We revealed that the number of births is lower on holidays, and especially among high-risk births such as low birthweight and preterm births. The frequency of high-risk birth has been increasing over the study period, and the variation by the day of week and between holiday and non-holiday have become more prevalent in recent years. [ABSTRACT FROM AUTHOR]

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المؤلفون: Khayargoli, Pranamika, Mayrand, Marie-Hélène, Niyibizi, Joseph, Audibert, François, Laporte, Louise, Lacaille, Julie, Carceller, Ana Maria, Lacroix, Jacques, Comète, Émilie, Coutlée, François, Trottier, Helen

المصدر: Viruses (1999-4915); Feb2024, Vol. 16 Issue 2, p298, 13p

مصطلحات موضوعية: HUMAN papillomavirus, VIRAL load, PREGNANCY, PREMATURE labor, FIRST trimester of pregnancy, THIRD trimester of pregnancy, CHILDBIRTH

مستخلص: Recent evidence shows increased preterm birth risk with human papillomavirus-16 (HPV16) infection during pregnancy. This study aimed to measure the association between HPV16 viral load during pregnancy and preterm birth. We used data from participants in the HERITAGE study. The Linear Array assay was used for HPV DNA testing on vaginal samples collected during the first and third trimesters of pregnancy. The HPV16 viral load was measured with a real-time polymerase chain reaction. We used logistic regression to measure the associations between HPV16 viral load during pregnancy and preterm birth (defined as birth before 37 weeks of gestation). The adjusted odd ratios (aORs) and the 95% confidence intervals [CIs] were estimated with inverse probability treatment weighting of the propensity score. This study included 48 participants who tested positive for HPV16 during the first trimester of pregnancy. The aOR for the association between first-trimester HPV16 viral load (higher viral load categorized with a cutoff of 0.5 copy/cell) was 13.04 [95% CI: 1.58–107.57]). Similar associations were found using different cutoffs for the categorization of viral load during the first and third trimesters. Our findings suggest a strong association between a high HPV16 viral load during pregnancy and preterm birth, demonstrating a biological gradient that reinforces the biological plausibility of a causal association. [ABSTRACT FROM AUTHOR]

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المؤلفون: Najafi, Zahra¹ (AUTHOR), Mirghafourvand, Mojgan² (AUTHOR), Ghanbari-Homaie, Solmaz³ (AUTHOR) homayisolmaz@gmail.com

المصدر: BMC Pregnancy & Childbirth. 4/13/2023, Vol. 23 Issue 1, p1-9. 9p.

مصطلحات موضوعية: *PREMATURE labor, *CONVENIENCE sampling (Statistics), *CHILDBIRTH, *CROSS-sectional method, *SATISFACTION

مصطلحات جغرافية: IRAN, TABRIZ (Iran)

مستخلص: Background: The unpredictable nature of preterm labour can be a stressful experience for the mother. The occurrence of preterm birth can lead to the failure of the mother's previous expectations regarding the process of labour and birth leading to negative perception towards birth. Methods: This descriptive-analytical cross-sectional study was conducted in Tabriz, Iran. We employed convenience sampling to recruit eligible mothers with term birth (314 women) and preterm birth (157 women). Childbirth Experience Questionnaire 2.0, Preterm Birth Experiences and Satisfaction Scale, and Delivery Fear Scale were used to measure the woman's fear of delivery during labour and birth experience. Data were analysed by general linear model. Results: The prevalence of negative birth experience in the term and preterm birth groups was 31.8% and 14.3%, respectively. The results of the multivariable general linear model, after the adjustment of demographic and obstetric characteristics, showed that there was no statistically significant difference between the two groups of mothers with term and preterm birth [β (95% CI): -0.06 (-0.22 to 0.09); p = 0.414] in terms of childbirth experience. However, the fear of delivery had a significant relationship with the childbirth experience [-0.02 (-0.03 to -0.01); p < 0.001]. Conclusion: There was no statistically significant difference in terms of women's childbirth experience between the mothers with term and preterm births. The fear of delivery during labour was the predictor of childbirth experience. In order to improve women's childbirth experience, interventions should be made to reduce their fear during labour. [ABSTRACT FROM AUTHOR]

المؤلفون: Blavier, Frédéric^1,2 fredericblavier@yahoo.fr, Barbe, Kurt³, Faron, Gilles¹, Doutreloup, Sébastien⁴, Boukerrou, Malik^5,6,7, Fuchs, Florent⁸, Gucciardo, Leonardo¹

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Dec2022, Vol. 35 Issue 25, p6663-6669. 7p.

مصطلحات موضوعية: *CHILDBIRTH, *PREMATURE labor, *ATMOSPHERIC temperature, *ATMOSPHERIC pressure, *TEMPERATURE effect

مصطلحات جغرافية: REUNION, BRUSSELS (Belgium), BELGIUM

مستخلص: Objective We studied potential effects of outdoor air temperatures or barometric pressure on births, preterm births and births associated with maternal hypertension. Methods 12,269 births were retrospectively reviewed in Brussel and 25,880 in South Reunion Island. National Belgium and French weather reference centers provided outdoor air temperatures and barometric pressures from the nearest weather stations on the corresponding birthdays. Poisson regression models were used to assess if outdoor air temperatures or barometric pressure could be correlated, immediately and several days later, with the number of daily births, preterm births and births associated with hypertension. Results Outdoor air temperature was significantly correlated to the number of daily births in Brussels. For each additional degree Celsius, overall births increased by 0.4% during the same day. Four days later, overall births increased by 1.8%, preterm births by 2.6% and births associated with hypertension by 5.7%. Similar observations on numbers of daily births were reported in South Reunion Island, without reaching statistical significance (p = .08). Conclusion As previously demonstrated in recent studies, increased air temperature leads progressively to higher rates of births and preterm births. An even stronger delayed effect of air temperature was observed on births associated with hypertension. This would be worth further investigating. [ABSTRACT FROM AUTHOR]

المؤلفون: Gruber, Teresa Mira, Ortlieb, Laura, Henrich, Wolfgang, Mechsner, Sylvia

المصدر: Journal of Clinical Medicine; Jan2024, Vol. 13 Issue 2, p414, 11p

مصطلحات موضوعية: PREGNANCY complications, CHILDBIRTH, PLACENTA praevia, PREMATURE labor, MATERNAL age, ENDOMETRIOSIS, PELVIC pain

مستخلص: Women with endometriosis (EM), particularly the manifestations of adenomyosis (AM) and deep infiltrating endometriosis (DIE), suffer from pain and sterility. DIE also appears with several specific obstetric complications. To determine the risk profile, we designed a retrospective case–control study. Primary outcomes were defined as the risk of preterm birth and caesarean delivery (CD). Primiparous singleton pregnancies in women with DIE were compared with controls without EM. We matched for mode of conception and maternal age. A total of 41 women diagnosed with DIE and 164 controls were recruited. A total of 92.7% of the cases were also diagnosed with AM. Preterm birth occurred in 12.2% of cases and in 6.7% of controls. The difference was not statistically significant (OR: 1.932; 95% CI: 0.632–5.907). The rate of CD was similar in both groups. Remarkably, placental implantation disorders in the form of placenta praevia were eight times more frequent in women with DIE (9.8%) than in controls (1.2%, OR: 8.757; 95% CI: 1.545–49.614). Neonatal outcome was similar in both groups. Four out of fourteen cases reported abdominal wall endometriosis after CD. Women with DIE/AM and with placenta praevia are at risk of bleeding complications. After CD, they can develop abdominal wall EM. We therefore suggest evaluating the birth mode in each woman with DIE/AM. [ABSTRACT FROM AUTHOR]

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المؤلفون: Gebreslasie, Kahsay Zenebe, Weldemariam, Solomon, Gebre, Gelawdyos, Zenebe, Dawit, Mehari, Mihreteab, Birhane, Aklil, Dewey, Rebecca Susan

المصدر: Scientific Reports; 1/16/2024, Vol. 14 Issue 1, p1-7, 7p

مصطلحات موضوعية: INTIMATE partner violence, LOW birth weight, BIRTH weight, PREGNANCY, PREMATURE labor, CHILDBIRTH, PREGNANT women

مصطلحات جغرافية: TIGRAY Kifle Hager (Ethiopia), ETHIOPIA

مستخلص: Intimate partner Violence (IPV) can affect any woman, irrespective of their economic status, religion, or culture. This is a human-rights issue and due to its prevalence and adverse effects on pregnancy and birth, it must be given greater attention. Further, there is a lack of data in the Tigray region about adverse birth outcomes due to intimate partner violence during pregnancy. The aim of this study was to assess intimate partner violence during pregnancy and its association with low birth weight and preterm birth in Tigray region. Across-sectional study design was used. 647 women were involved in the study. Simple random sampling techniques were employed to select health facilities and systematic sampling was used to select study participants. Data were entered using Epi info version 3.5.1 and was analyzed using SPSSversion 20. Logistic regression analysis was conducted to assess the association between exposure to intimate partner violence during pregnancy and preterm birth and low birth weight while adjusting for possible confounders. The prevalence of intimate partner violence during pregnancy was 7.3% and the prevalence of low birth weight and preterm birth were 18.5% and 10.8% respectively. There was a statistically significant association between exposure to intimate partner violence during pregnancy and low birth weight. After adjustment for socioeconomic status, women's habits and obstetric factors, the pregnant women who were exposed to intimate partner violence during pregnancy were two times more likely to have a child with a low birth weight (2.39 (95% CI: 1.26–4.55)). The prevalence of intimate partner violence during pregnancy, low birth weight, and preterm birth in this study was high. Women who experienced intimate partner violence during pregnancy had an increased risk of low birth weight. These findings justify a call to the federal minster of health to take measures aimed at avoiding intimate partner violence during pregnancy to reduce adverse birth outcomes. [ABSTRACT FROM AUTHOR]

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المؤلفون: Orimoloye, Helen T., He, Di, Li, Tong, Janzen, Carla, Barjaktarevic, Igor, Wang, Xuexia, Hansen, Johnni, Heck, Julia E.

المصدر: PLoS ONE; 1/2/2024, Vol. 19 Issue 1, p1-14, 14p

مصطلحات موضوعية: PREGNANCY complications, TRYPSIN inhibitors, LOW birth weight, CHILDBIRTH, POISSON regression, DELIVERY (Obstetrics), PREMATURE labor

مصطلحات جغرافية: DENMARK

مستخلص: Background: Alpha-1 antitrypsin deficiency (AATD) is related to developing lung and liver disease, but no large-scale studies examine its association with birth outcomes. Objective: We investigated the risk of pregnancy complications and adverse birth outcomes in mothers and children with AATD. Methods: Using a large cohort data of Danish mothers and children with AATD from 1973 to 2013 (n = 2,027,229), with 559 cases (305 mothers and 254 children). We conducted Poisson regression to examine associations between alpha-1 antitrypsin deficiency, adverse birth outcomes, and pregnancy complications in mothers and children. Results: AATD was related to term low birth weight [<2500g; Risk Ratio(RR) = 2.04, 95% confidence interval (CI): 1.50–2.79], lowest quartile of abdominal circumference at birth in children of non-smoking mothers (RR = 1.55, 95% CI: 1.14–2.11), delivery via Cesarean-section (RR = 1.59, 95% CI: 1.05–2.40), preterm birth (RR = 1.54, 95% CI: 1.19–2.00) and preeclampsia (RR = 2.64, 95% CI: 1.76–3.94). Conclusions: This emphasizes the need for mothers with AATD to be monitored closely during pregnancy to reduce the risk of adverse birth outcomes. Routine screening for alpha-1 antitrypsin in pregnancy may be considered among mothers with a pulmonary and liver disease history. [ABSTRACT FROM AUTHOR]

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المؤلفون: PAŘÍZEK, Antonín, HILL, Martin, DUŠKOVÁ, Michaela, KOLÁTOROVÁ, Lucie, SUCHOPÁR, Josef, ŠIMJÁK, Patrik, ANDERLOVÁ, Kateřina, KUDOVÁ, Eva, ROGALEWICZ, Vladimír, VACEK, Jaroslav, KOUDELKOVÁ, Marcela, CHLOUPKOVÁ, Renata, ALBLOVÁ, Miroslava, PAŘÍZKOVÁ, Petra, LAŠTŮVKA, Zdeněk, BARTÁK, Miroslav

المصدر: Physiological Research; 2023 Supplement, Vol. 72, pS381-S387, 7p

مصطلحات موضوعية: CANNABINOIDS, PREMATURE labor, MISCARRIAGE, PREGNANT women, CHILDBIRTH

مستخلص: Spontaneous preterm birth (sPTB) is a major cause of perinatal morbidity and mortality, even in developed countries. Prediction of sPTB is therefore a valuable tool to reduce the associated risks. The current standard for the prediction of sPTB consists, in addition to anamnestic data, of previous sPTB and previous second trimester miscarriage, measurement of cervical length by transvaginal ultrasound (TVU CL) together with assessment of fetal fibronectin levels in cervicovaginal fluid. Other evaluation parameters, such as the level of endocannabinoids in the pregnant woman's blood, could increase the sensitivity of this management. Endocannabinoids (eCBs) are a part of the endocannabinoid system (ECS); out of them anandamide (arachidonoyl-ethanolamide, AEA), in particular, plays an important role in the regulation of pregnancy and childbirth. We present the protocol for an open, non-randomized study to evaluate concentrations of AEA and other endocannabinoids: 2-linoleoylglycerol (2-AG), 2-linoleoylglycerol (2-LG), 2-oleoylglycerol (2-OG), and 2-arachidonoyldopamine (2-ADOPA or also NADA) in the blood of pregnant women as potential predictors of sPTB. In a total of 230 women with a history of sPTB or miscarriage, eCBs levels between 22 and 28 weeks of gestation will be assessed from maternal blood, in addition to the standard procedure. The aim of the study is to determine the relationship between blood concentrations of the endocanna-binoids tested and the risk of sPTB. The results of this study will describe the prognostic significance of maternal blood eCBs levels for sPTB, and could subsequently enable improved screening programs for early identification of sPTB. [ABSTRACT FROM AUTHOR]

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المؤلفون: Kramer, Boris W., Abman, Steven, Daly, Mandy, Jobe, Alan H., Niklas, Victoria

المصدر: Paediatric Respiratory Reviews; Dec2023, Vol. 48, p24-29, 6p

مصطلحات موضوعية: LUNG development, PREMATURE labor, SOMATOMEDIN C, CHILDBIRTH, PREMATURE infants, MECONIUM aspiration syndrome, CARDIOVASCULAR diseases

مستخلص: The past decades have seen markedly improved survival of increasingly immature preterm infants, yet major health complications persist. This is particularly true for bronchopulmonary dysplasia (BPD), the chronic lung disease of prematurity, which has become the most common sequelae of prematurity and a significant predictor of respiratory morbidity throughout childhood as well as adult life, neurodevelopmental disability, cardiovascular disease, and even death. The need for novel approaches to reduce BPD and related complications of prematurity has never been more critical. Thus, despite major advances in the use of antenatal steroids, surfactant therapy, and improvements in respiratory support, there is a persistent need for developing therapeutic strategies that more specifically reflect our growing understanding of BPD in the post-surfactant age, or the "new BPD." In contrast with the severe lung injury leading to marked fibroproliferative disease from the past, the "new BPD" is primarily characterized by an arrest of lung development as related to more extreme prematurity. This distinction and the continued high incidence of BPD and related sequelae suggest the need to identify therapies that target critical mechanisms that support lung growth and maturation in conjunction with treatments to improve respiratory outcomes across the lifespan. As the prevention of BPD and its severity remains a primary goal, we highlight the concept from preclinical and early clinical observations that insulin-like growth factor 1 (IGF-1) can potentially support the natural sequence of lung growth as a replacement therapy after preterm birth. Data supporting this hypothesis are robust and include observations that low IGF-1 levels persist after extremely preterm birth in human infants and strong preclinical data from experimental models of BPD highlight the therapeutic benefit of IGF-1 in reducing disease. Importantly, phase 2a clinical data in extremely premature infants where replacement of IGF-1 with a human recombinant human IGF-1 complexed with its main IGF-1 binding protein 3, significantly reduced the most severe form of BPD, which is strongly associated with multiple morbidities that have lifelong consequences. As physiologic replacement therapy of surfactant heralded the success of reducing acute respiratory distress syndrome in preterm infants, the paradigm has the potential to become the platform for discovering the next generation of therapies like IGF-1, which becomes deficient after extremely premature birth where endogenous production by the infant is not sufficient to maintain the physiologic levels adequate to support normal organ development and maturation. [ABSTRACT FROM AUTHOR]

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