المؤلفون: Ünal, Canan, Tanaçan, Atakan, Fadiloğlu, Erdem, Çağan, Murat, Yücesoy, Halise Meltem, Beksaç, Mehmet Sinan

المصدر: Journal of the Turkish-German Gynecological Association; Dec2023, Vol. 24 Issue 4, p241-245, 5p

مصطلحات موضوعية: OBSTRUCTIVE lung disease diagnosis, ECHOCARDIOGRAPHY, CHILDBIRTH, STATURE, LENGTH of stay in hospitals, PNEUMONIA, ACADEMIC medical centers, BODY weight, PERICARDIAL effusion, PREGNANT women, RETROSPECTIVE studies, MANN Whitney U Test, GESTATIONAL age, PREGNANCY outcomes, VITAL capacity (Respiration), PREECLAMPSIA, RISK assessment, SCOLIOSIS, SYMPTOMS, PULMONARY function tests, DESCRIPTIVE statistics, CHI-squared test, BIRTH weight, FORCED expiratory volume, HOSPITAL care, PUERPERIUM, DATA analysis software, CESAREAN section, LONGITUDINAL method, PREMATURE labor

مصطلحات جغرافية: TURKEY

مستخلص: Objective: To demonstrate the impact of scoliosis on pregnancy and gestational outcome. Material and Methods: We retrospectively evaluated gestational outcomes of pregnant women with scoliosis at Hacettepe University Hospital between 2008 and 2018. Cases were grouped according to the presence of previous scoliosis surgery and compared in terms of gestational week at birth, birthweight, rate of neonatal intensive care unit admission, hospitalization during pregnancy, route of delivery, type of anesthesia at labor and postpartum intensive care unit admission rate. Ejection fraction (EF), functional vital capacity (FVC), forced expiratory volume (FEV1) and FEV1/FVC ratio values were also recorded. Results: A total of 23 women were included, of whom 12 (52.2%) had a prior scoliosis surgery. One of the 23 (4.3%) cases was terminated due to respiratory problems, while the remaining 22 cases resulted in deliveries. The median gestational week at birth was 38.2 and the median birth weight was 3150 g. Median (range) maternal height was 143 (80-160) cm while median (range) maternal weight was 51 (35-86) kg. Three (13.6%) were diagnosed with restrictive lung disease. No significant difference was found between operated and non-operated groups in terms of respiratory function test results, cardiac EF and other related demographic and clinical features. Overall cesarean delivery rate was 63.6% (14/22) and cesarean section rate was significantly higher in the operated group (83.3% versus 40%) (p=0.04). Conclusion: Cesarean section rate was increased in this cohort of pregnancies in women with scoliosis and who had previous scoliosis surgery. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of the Turkish-German Gynecological Association is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Guo, Xiaojing¹, Li, Xiaoqiong², Qi, Tingting², Pan, Zhaojun³, Zhu, Xiaoqin⁴, Wang, Hui⁴, Dong, Ying¹, Yue, Hongni^3,4 yuehongni@hotmail.com, Sun, Bo¹ bsun@shmu.edu.cn

المصدر: BMC Pregnancy & Childbirth. 4/10/2021, Vol. 21 Issue 1, p1-12. 12p.

مصطلحات موضوعية: *CHILDBIRTH, *PREMATURE labor, *GESTATIONAL age, *MORTALITY

مصطلحات جغرافية: CHINA

مستخلص: Background: Despite 15–17 millions of annual births in China, there is a paucity of information on prevalence and outcome of preterm birth. We characterized the outcome of preterm births and hospitalized preterm infants by gestational age (GA) in Huai'an in 2015, an emerging prefectural region of China. Methods: Of 59,245 regional total births, clinical data on 2651 preterm births and 1941 hospitalized preterm neonates were extracted from Huai'an Women and Children's Hospital (HWCH) and non-HWCH hospitals in 2018–2020. Preterm prevalence, morbidity and mortality rates were characterized and compared by hospital categories and GA spectra. Death risks of preterm births and hospitalized preterm infants in the whole region were analyzed with multivariable Poisson regression. Results: The prevalence of extreme, very, moderate, late and total preterm of the regional total births were 0.14, 0.53, 0.72, 3.08 and 4.47%, with GA-specific neonatal mortality rates being 44.4, 15.8, 3.7, 1.5 and 4.3%, respectively. There were 1025 (52.8% of whole region) preterm admissions in HWCH, with significantly lower in-hospital death rate of inborn (33 of 802, 4.1%) than out-born (23 of 223, 10.3%) infants. Compared to non-HWCH, three-fold more neonates in HWCH were under critical care with higher death rate, including most extremely preterm infants. Significantly all-death risks were found for the total preterm births in birth weight < 1000 g, GA < 32 weeks, amniotic fluid contamination, Apgar-5 min < 7, and birth defects. For the hospitalized preterm infants, significantly in-hospital death risks were found in out-born of HWCH, GA < 32 weeks, birth weight < 1000 g, Apgar-5 min < 7, birth defects, respiratory distress syndrome, necrotizing enterocolitis and ventilation, whereas born in HWCH, antenatal glucocorticoids, cesarean delivery and surfactant use decreased the death risks. Conclusions: The integrated data revealed the prevalence, GA-specific morbidity and mortality rate of total preterm births and their hospitalization, demonstrating the efficiency of leading referral center and whole regional perinatal-neonatal network in China. The concept and protocol should be validated in further studies for prevention of preterm birth. [ABSTRACT FROM AUTHOR]

المؤلفون: Song, Ashley Y., Bulka, Catherine M., Niemiec, Sierra S., Kechris, Katerina, Boyle, Kristen E., Marsit, Carmen J., O'Shea, T. Michael, Fry, Rebecca C., Lyall, Kristen, Fallin, M. Daniele, Volk, Heather E., Ladd-Acosta, Christine

المصدر: Epigenetics; 2023, Vol. 18 Issue 1, p1-7, 7p

مصطلحات موضوعية: CHILD development, BODY mass index, PREMATURE labor, CHILDBIRTH, AUTISM spectrum disorders, EPIGENETICS, GESTATIONAL age, AGE groups

Reviews & Products: DIAGNOSTIC & Statistical Manual of Mental Disorders (Book)

مستخلص: Background: 'Epigenetic clocks' have been developed to accurately predict chronologic gestational age and have been associated with child health outcomes in prior work. Methods: We meta-analysed results from four prospective U.S cohorts investigating the association between epigenetic age acceleration estimated using blood DNA methylation collected at birth and preschool age Childhood Behavior Checklist (CBCL) scores. Results: Epigenetic ageing was not significantly associated with CBCL total problem scores (ß = 0.33, 95% CI: -0.95, 0.28) and DSM-oriented pervasive development problem scores (ß = -0.23, 95% CI: -0.61, 0.15). No associations were observed for other DSM-oriented subscales. Conclusions: The meta-analysis results suggest that epigenetic gestational age acceleration is not associated with child emotional and behavioural functioning for preschool age group. These findings may relate to our study population, which includes two cohorts enriched for ASD and one preterm birth cohort.; future work should address the role of epigenetic age in child health in other study populations. Abbreviations: DNAm: DNA methylation; CBCL: Child Behavioral Checklist; ECHO: Environmental Influences on Child Health Outcomes; EARLI: Early Autism Risk Longitudinal Investigation; MARBLES: Markers of Autism Risk in Babies - Learning Early Signs; ELGAN: Extremely Low Gestational Age Newborns; ASD: autism spectrum disorder; BMI: body mass index; DSM: Diagnostic and Statistical Manual of Mental Disorders. [ABSTRACT FROM AUTHOR]

: Copyright of Epigenetics is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Kennedy, Eilis¹ (AUTHOR) ekennedy@tavi-port.nhs.uk, O'Nions, Elizabeth¹ (AUTHOR), Wolke, Dieter² (AUTHOR), Johnson, Samantha³ (AUTHOR)

المصدر: Journal of the American Academy of Child & Adolescent Psychiatry. Sep2021, Vol. 60 Issue 9, p1066-1068. 3p.

مصطلحات موضوعية: *PREMATURE labor, *ADOLESCENT psychiatry, *CHILDBIRTH, *CHILD psychiatry, *HIGH-income countries, *RESEARCH, *PREMATURE infants, *RESEARCH methodology, *GESTATIONAL age, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies

مستخلص: Obstetric factors have long been recognized as risk factors for the later development of poor mental health. One of the most consistently reported of these associations is for preterm birth (birth before 37 weeks' gestation), a form of early adversity that impacts health and development across the life course. Preterm birth is not uncommon: in 2014, 10.6% of live births globally (nearly 15 million babies) were preterm.1 Advances in neonatal care since the early 1990s have dramatically increased the numbers of babies who survive extreme preterm birth (birth at <28 weeks' gestation) in high-income countries. This has led to growing interest in how extreme preterm birth impacts longer term outcomes including psychosocial development across the life span. [ABSTRACT FROM AUTHOR]

المؤلفون: Gonçalves, Joana L.¹ joanaglopes@gmail.com, Fuertes, Marina¹, Alves, Maria João¹, Antunes, Sandra², Almeida, Ana Rita³, Casimiro, Rute³, Santos, Margarida^2,4

المصدر: BMC Pregnancy & Childbirth. 5/6/2020, Vol. 20 Issue 1, p1-16. 16p.

مصطلحات موضوعية: *PREMATURE labor, *PREMATURE infants, *MOTHER-infant relationship, *MATERNAL health services, *CHILDBIRTH, *POSTPARTUM depression, *PREGNANCY, *NEONATAL intensive care, *PSYCHOLOGY of mothers, *GESTATIONAL age, *NEONATAL intensive care units, *RESEARCH funding, *LABOR (Obstetrics), *MOTHER-child relationship

مستخلص: Background: Mothers' reports about pregnancy, maternity and their experiences during the perinatal period have been associated with infants' later quality of attachment and development. Yet, there has been little research with mothers of very preterm newborns. This study aimed to explore mothers' experiences related to pregnancy, premature birth, relationship with the newborn, and future perspectives, and to compare them in the context of distinct infants' at-birth-risk conditions.Methods: A semi-structured interview was conducted with women after birth, within the first 72 h of the newborn's life. A total of 150 women participated and were divided in three groups: (1) 50 mothers of full-term newborns (Gestational Age (GA) ≥ 37 weeks; FT), (2) 50 mothers of preterm newborns (GA 32-36 weeks; PT) and (3) 50 mothers of very preterm newborns (GA < 32 weeks; VPT).Results: Mothers of full-term infants responded more often that their children were calm and that they did not expect difficulties in taking care of and providing for the baby. Mothers of preterm newborns although having planned and accepted well the pregnancy (with no mixed or ambivalent feelings about it) and while being optimistic about their competence to take care of the baby, mentioned feeling frightened because of the unexpected occurrence of a premature birth and its associated risks. Mothers of very preterm newborns reported more negative and distressful feelings while showing more difficulties in anticipating the experience of caring for their babies.Conclusion: The results indicate that Health Care Systems and Neonatal Care Policy should provide differentiated psychological support and responses to mothers, babies and families, taking into account the newborns' GA and neonatal risk factors. [ABSTRACT FROM AUTHOR]

المؤلفون: Erkamp, Jan S.^1,2 (AUTHOR), Voerman, Ellis^1,2 (AUTHOR), Steegers, Eric A. P.³ (AUTHOR), Mulders, Annemarie G. M. G. J.³ (AUTHOR), Reiss, Irwin K. M.^1,4 (AUTHOR), Duijts, Liesbeth^1,4,5 (AUTHOR), Jaddoe, Vincent W. V.^1,2 (AUTHOR), Gaillard, Romy^1,2 (AUTHOR) r.gaillard@erasmusmc.nl

المصدر: BMC Medicine. 4/7/2020, Vol. 18 Issue 1, p1-12. 12p. 2 Charts, 3 Graphs.

مصطلحات موضوعية: *PREMATURE labor, *FETAL ultrasonic imaging, *GESTATIONAL age, *VASCULAR resistance, *CHILDBIRTH, *ABRUPTIO placentae

مستخلص: Background: Preterm birth, small size for gestational age (SGA) and large size for gestational age (LGA) at birth are major risk factors for neonatal and long-term morbidity and mortality. It is unclear which periods of pregnancy are optimal for ultrasound screening to identify fetuses at risk of preterm birth, SGA or LGA at birth. We aimed to examine whether single or combined second and third trimester ultrasound in addition to maternal characteristics at the start of pregnancy are optimal to detect fetuses at risk for preterm birth, SGA and LGA.Methods: In a prospective population-based cohort among 7677 pregnant women, we measured second and third trimester estimated fetal weight (EFW), and uterine artery pulsatility and umbilical artery resistance indices as placenta flow measures. Screen positive was considered as EFW or placenta flow measure < 10th or > 90th percentile. Information about maternal age, body mass index, ethnicity, parity, smoking, fetal sex and birth outcomes was available from questionnaires and medical records. Screening performance was assessed via receiver operating characteristic (ROC) curves and area under the curve (AUC) along with sensitivity at different false-positive rates.Results: Maternal characteristics only and in combination with second trimester EFW had a moderate performance for screening for each adverse birth outcome. Screening performance improved by adding third trimester EFW to the maternal characteristics (AUCs for preterm birth 0.64 (95%CI 0.61 to 0.67); SGA 0.79 (95%CI 0.78 to 0.81); LGA 0.76 (95%CI 0.75; 0.78)). Adding third trimester placenta measures to this model improved only screening for risk of preterm birth (AUC 0.72 (95%CI 0.66 to 0.77) with sensitivity 37% at specificity 90%) and SGA (AUC 0.83 (95%CI 0.81 to 0.86) with sensitivity 55% at specificity 90%). Combining second and third trimester fetal and placental ultrasound did not lead to a better performance as compared to using only third trimester results.Conclusions: Combining single third trimester fetal and placental ultrasound results with maternal characteristics has the best screening performance for risks of preterm birth, SGA and LGA. As compared to second trimester screening, third trimester screening may double the detection of fetuses at risk of common adverse birth outcomes. [ABSTRACT FROM AUTHOR]

المؤلفون: Crump, Casey^1,2 (AUTHOR) casey.crump@mssm.edu, Friberg, Danielle³ (AUTHOR), Li, Xinjun⁴ (AUTHOR), Sundquist, Jan^1,2,4 (AUTHOR), Sundquist, Kristina^1,2,4 (AUTHOR)

المصدر: International Journal of Epidemiology. Dec2019, Vol. 48 Issue 6, p2039-2049. 11p.

مصطلحات موضوعية: *PREMATURE labor, *SLEEP apnea syndromes, *CHILDBIRTH, *GESTATIONAL age, *NEUROBEHAVIORAL disorders, *COMPARATIVE studies, *PREMATURE infants, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *RESEARCH funding, *EVALUATION research, *PROPORTIONAL hazards models

مصطلحات جغرافية: SWEDEN

مستخلص: Background: Preterm birth (gestational age <37 weeks) has previously been associated with cardiometabolic and neuropsychiatric disorders into adulthood, but has seldom been examined in relation to sleep disorders. We conducted the first population-based study of preterm birth in relation to sleep-disordered breathing (SDB) from childhood into mid-adulthood.Methods: A national cohort study was conducted of all 4 186 615 singleton live births in Sweden during 1973-2014, who were followed for SDB ascertained from nationwide inpatient and outpatient diagnoses through 2015 (maximum age 43 years). Cox regression was used to examine gestational age at birth in relation to SDB while adjusting for other perinatal and maternal factors, and co-sibling analyses assessed for potential confounding by unmeasured shared familial factors.Results: There were 171 100 (4.1%) persons diagnosed with SDB in 86.0 million person-years of follow-up. Preterm birth was associated with increased risk of SDB from childhood into mid-adulthood, relative to full-term birth (39-41 weeks) [adjusted hazard ratio (aHR), ages 0-43 years: 1.43; 95% confidence interval (CI), 1.40, 1.46; P <0.001; ages 30-43 years: 1.40; 95% CI, 1.34, 1.47; P <0.001]. Persons born extremely preterm (<28 weeks) had more than 2-fold risks (aHR, ages 0-43 years: 2.63; 95% CI, 2.41, 2.87; P <0.001; ages 30-43 years: 2.22; 95% CI, 1.64, 3.01; P <0.001). These associations affected both males and females, but accounted for more SDB cases among males (additive interaction, P = 0.003). Co-sibling analyses suggested that these findings were only partly due to shared genetic or environmental factors in families.Conclusions: Preterm-born children and adults need long-term follow-up for anticipatory screening and potential treatment of SDB. [ABSTRACT FROM AUTHOR]

المؤلفون: Ronzoni, Stefania¹ (AUTHOR) stefania.ronzoni@sunnybrook.ca, D'Souza, Rohan² (AUTHOR), Shynlova, Oksana³ (AUTHOR), Lye, Stephen³ (AUTHOR), Murphy, Kellie E.² (AUTHOR)

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Oct2019, Vol. 32 Issue 20, p3473-3479. 7p.

مصطلحات موضوعية: *PREMATURE labor, *PREGNANCY, *PREMATURE rupture of fetal membranes, *GESTATIONAL age, *CHILDBIRTH

مستخلص: Objective: To compare maternal blood endotoxin activity (EA) in women with preterm premature rupture of membranes (PPROM) with gestational age (GA) matched controls; to evaluate serial EA till birth in PPROM and its correlation with latency to delivery. Methods: We followed singleton preterm pregnancies from admission with PPROM until birth. Uncomplicated, GA-matched pregnancies served as controls. Demographics, birth and neonatal outcomes were collected. EA (EAA™) was assessed serially in PPROM and at study entry in controls. EA was compared using Mann Whitney and Wilcoxon tests, p value <.05 was considered significant. Results: We recruited 20 cases of PPROM and 20 controls. Demographics were similar between groups. Mean GA of PPROM was 29.0 ± 2.2 weeks and median latency was 7.5 (IQR 14.1) weeks. Median EA at admission following PPROM was significantly elevated over controls (0.43 (0.18) versus 0.36 (0.2); p <.02). Overall there was no difference in median EA at admission and in labor (0.43 (0.18) versus 0.33 (0.21); p =.2) following PPROM. However, on comparing cases with latency to delivery ≤7 days (n = 10) versus >7 days (n = 10), there was a significant drop in EA in the latter group (0.44 (0.2) versus 0.34 (0.2); p <.004). Conclusions: EA in PPROM represents a promising biomarker in predicting the clinical evolution of preterm birth. [ABSTRACT FROM AUTHOR]

المؤلفون: Levin, Heather I.^1,2 heather.levin@gmail.com, Sciscione, Anthony³, Ananth, Cande V.^1,4, Drassinower, Daphnie^1,5, Obican, Sarah G.^1,6, Wapner, Ronald J.¹

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Aug2018, Vol. 31 Issue 16, p2136-2140. 5p.

مصطلحات موضوعية: *PREMATURE labor, *PREGNANCY complications, *LABOR complications (Obstetrics), *PREMATURE infants, *CHILDBIRTH, *BED rest, *GESTATIONAL age, *LONGITUDINAL method, *ACTIVITIES of daily living

مستخلص: Purpose: We sought to determine whether activity restriction (AR) in a cohort of women at high risk for preterm delivery is associated with the risk of preterm delivery.Materials and Methods: This is a secondary analysis of the Maternal-Fetal Medicine Units MFMU's Preterm Prediction Study; a multicenter prospective cohort study designed to identify risk factors of preterm birth (PTB). The study group consisted of women with a singleton gestation that at their first study visit (23-24 weeks) had at least one of the following criteria: patient reported contractions, severe back pain, a cervical length <15 mm, spotting, protruding membranes, or positive fetal fibronectin. Women were assessed for AR at a 27- to 29-week study visit. Associations between AR and preterm delivery (<37 weeks) were examined through logistic regression models before and after adjustment for confounders.Results: Of the 1086 women that met the inclusion criteria, 16.5% (n = 179) delivered preterm. In this cohort, 9.7% (n = 105) of women were recommended AR, with 37.1% (n = 39) having a PTB. In the group not recommended AR (n = 981), 14.3% (n = 140) delivered preterm.Conclusion: In this cohort of women at high risk for PTB, activity restriction was associated with an increased risk of PTB. The use of AR in this population should be discouraged. [ABSTRACT FROM AUTHOR]

المؤلفون: Mosbah, Alaa¹ (AUTHOR) alaamosbah@hotmail.com, Barakat, Rafik¹ (AUTHOR), Nabiel, Yasmin² (AUTHOR), Barakat, Ghada² (AUTHOR)

المصدر: Journal of Maternal-Fetal & Neonatal Medicine. Mar2018, Vol. 31 Issue 6, p720-725. 6p.

مصطلحات موضوعية: *PAPILLOMAVIRUSES, *PREMATURE labor, *OBSTETRICS, *MEDICINE, *CHILDBIRTH, *PREMATURE labor prevention, *PAPILLOMAVIRUS disease diagnosis, *GENE expression, *GESTATIONAL age, *PAPILLOMAVIRUS diseases, *POLYMERASE chain reaction, *PROTEOLYTIC enzymes, *SPECIALTY hospitals, *CASE-control method

مصطلحات جغرافية: EGYPT

مستخلص: Introduction: This study aimed to detect the correlation between human papillomavirus (HPV) and spontaneous preterm labor in Egyptian women and its association to the human papilloma viral load and MPP2 gene expression.Material and Methods: We performed an observational comparative case-control study in Department of Obstetric and Gynecology, Mansoura University Hospitals over women presented with spontaneous preterm labor, besides females admitted for giving birth at full term to detect conserved sequence in HPV-L1 gene (GP5/GP6) followed by genotype detection of high- and low-risk HPVs with quantification of the viral load and the MMP2 gene expression using real-time polymerase chain reaction (PCR).Results: The prevalence of HPV was 18.1% in preterm females, but only 4% in full-term women (p value = 0.019*). Twenty percent were PCR positive for HPV 16 and 40% for HPV 18 whereas none of the control was positive for any of the studied high-risk genotypes. Thirty percent were PCR positive for HPV 6 and 10% were positive for HPV 11. MMP2 gene expression was significantly higher in preterm than full term. Human papilloma viral load was found to be positively correlated to the rate of MMP2 expression and the gestational age was significantly related to the viral load and the rate of expression of MMP2 gene.Conclusion: Human pabilloma virus especially high-risk genotypes was correlated to spontaneous preterm labor in Egyptian females through increasing early expression of MMP2 gene. The time of occurrence of preterm labor was affected by the viral load and so the rate of expression of MMP2 gene. [ABSTRACT FROM AUTHOR]