التفاصيل البيبلوغرافية
| العنوان: |
The Genetics of Preterm Birth: Using What We Know to Design Better Association Studies. |
| المؤلفون: |
Weinberg, Clarice R.1 weinber2@niehs.nih.gov, Min Shi |
| المصدر: |
American Journal of Epidemiology. Dec2009, Vol. 170 Issue 11, p1373-1381. 9p. 5 Charts, 4 Graphs. |
| مصطلحات موضوعية: |
*PREMATURE labor, *LABOR complications (Obstetrics), *PREGNANCY, *CHILDBIRTH, *LOG-linear models, *PREMATURE infants, *GENETICS |
| مستخلص: |
Women delivering preterm are at greatly increased risk of another preterm birth in subsequent pregnancies, reflecting effects of the environment, genetics, or both. Recent literature tells an increasingly coherent story about genetic susceptibility. Women who change partners after delivering preterm retain their elevated risk, whereas fathers who change partners do not. Women who themselves were preterm are at increased risk, an association not seen in fathers. Women with a half-sister who delivered preterm are at increased risk only if the shared parent was the mother. Concordance for preterm delivery is elevated in monozygotic compared with dizygotic twin mothers but not in monozygotic twin fathers. Several mechanisms could be operating: mitochondrial genes, maternal genes, or fetal genes expressing only the maternally derived copy. The authors compare 3 study designs for their ability to detect variants and to distinguish among mechanisms underlying heritability of this common outcome. The case-parent triad design offers robustness against self-selection and genetic population stratification, providing for estimation of genetic effects that are fetal, maternal, or that depend on the parent of origin. A case-base approach compares case-mothers with randomly sampled baby-mother pairs and permits estimation of the same relative risk parameters. Both designs offer important advantages over the commonly applied case-mother/control-mother design. [ABSTRACT FROM PUBLISHER] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder