التفاصيل البيبلوغرافية
| العنوان: |
Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis. |
| المؤلفون: |
Evans, Idris V. R., Phillips, Gary S., Alpern, Elizabeth R., Angus, Derek C., Friedrich, Marcus E., Kissoon, Niranjan, Lemeshow, Stanley, Levy, Mitchell M., Parker, Margaret M., Terry, Kathleen M., Watson, R. Scott, Weiss, Scott L., Zimmerman, Jerry, Seymour, Christopher W. |
| المصدر: |
JAMA: Journal of the American Medical Association; 7/24/2018, Vol. 320 Issue 4, p358-367, 10p |
| مصطلحات موضوعية: |
SEPTICEMIA in children, HOSPITAL mortality, CHILD mortality, ANTIBIOTICS, BOLUS drug administration, THERAPEUTICS, SEPTICEMIA treatment, EMERGENCY medical services, HOSPITAL emergency services, LONGITUDINAL method, MANAGEMENT, MEDICAL protocols, RESEARCH funding, RISK assessment, SEPSIS, TIME, ODDS ratio |
| مصطلحات جغرافية: |
NEW York (State) |
| مستخلص: |
Importance: The death of a pediatric patient with sepsis motivated New York to mandate statewide sepsis treatment in 2013. The mandate included a 1-hour bundle of blood cultures, broad-spectrum antibiotics, and a 20-mL/kg intravenous fluid bolus. Whether completing the bundle elements within 1 hour improves outcomes is unclear.Objective: To determine the risk-adjusted association between completing the 1-hour pediatric sepsis bundle and individual bundle elements with in-hospital mortality.Design, Settings, and Participants: Statewide cohort study conducted from April 1, 2014, to December 31, 2016, in emergency departments, inpatient units, and intensive care units across New York State. A total of 1179 patients aged 18 years and younger with sepsis and septic shock reported to the New York State Department of Health who had a sepsis protocol initiated were included.Exposures: Completion of a 1-hour sepsis bundle within 1 hour compared with not completing the 1-hour sepsis bundle within 1 hour.Main Outcomes and Measures: Risk-adjusted in-hospital mortality.Results: Of 1179 patients with sepsis reported at 54 hospitals (mean [SD] age, 7.2 [6.2] years; male, 54.2%; previously healthy, 44.5%; diagnosed as having shock, 68.8%), 139 (11.8%) died. The entire sepsis bundle was completed in 1 hour in 294 patients (24.9%). Antibiotics were administered to 798 patients (67.7%), blood cultures were obtained in 740 patients (62.8%), and the fluid bolus was completed in 548 patients (46.5%) within 1 hour. Completion of the entire bundle within 1 hour was associated with lower risk-adjusted odds of in-hospital mortality (odds ratio [OR], 0.59 [95% CI, 0.38 to 0.93], P = .02; predicted risk difference [RD], 4.0% [95% CI, 0.9% to 7.0%]). However, completion of each individual bundle element within 1 hour was not significantly associated with lower risk-adjusted mortality (blood culture: OR, 0.73 [95% CI, 0.51 to 1.06], P = .10; RD, 2.6% [95% CI, -0.5% to 5.7%]; antibiotics: OR, 0.78 [95% CI, 0.55 to 1.12], P = .18; RD, 2.1% [95% CI, -1.1% to 5.2%], and fluid bolus: OR, 0.88 [95% CI, 0.56 to 1.37], P = .56; RD, 1.1% [95% CI, -2.6% to 4.8%]).Conclusions and Relevance: In New York State following a mandate for sepsis care, completion of a sepsis bundle within 1 hour compared with not completing the 1-hour sepsis bundle within 1 hour was associated with lower risk-adjusted in-hospital mortality among patients with pediatric sepsis and septic shock. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
