The clinical significance of changes in ezrin expression in osteosarcoma of children and young adults
| العنوان: | The clinical significance of changes in ezrin expression in osteosarcoma of children and young adults |
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| المؤلفون: | Elżbieta Michalak, Katarzyna Szamotulska, Malgorzata Lenarcik, Teresa Klepacka, Irena Koch, Iwona Lugowska, Ewa Mierzejewska |
| المصدر: | Tumor Biology. 37:12071-12078 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Pathology, Adolescent, medicine.medical_treatment, Bone Neoplasms, macromolecular substances, Metastasis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Ezrin, Internal medicine, Biopsy, medicine, Humans, Clinical significance, Child, Osteosarcoma, Chemotherapy, medicine.diagnostic_test, business.industry, General Medicine, Prognosis, medicine.disease, Actin cytoskeleton, Cytoskeletal Proteins, 030104 developmental biology, 030220 oncology & carcinogenesis, Localized disease, Female, business |
| الوصف: | Ezrin is a protein that functions as a cross-linker between actin cytoskeleton and plasma membrane. Its clinical role in osteosarcoma is unclear. The aim of this study was to investigate, in osteosarcoma, the prognostic value of ezrin expression at biopsy and changes in expression levels after preoperative chemotherapy. Thirty-eight newly diagnosed osteosarcoma patients aged 6-23 years were included. At diagnosis, 20 patients had localized disease, the others had distant metastases. Median follow-up was 75 months (range 13-135). Ezrin expression was assessed immunohistochemically in biopsy tissue and primary tumour specimens resected after chemotherapy. The influence on survival of changes in ezrin expression after chemotherapy was analysed. Ezrin expression was significantly higher after preoperative chemotherapy and changes compared to biopsy tissue were significantly lower in patients with early progression than in patients with relapse or no further evidence of disease (p = 0.006 and p = 0.002, respectively). Similarly, ezrin expression was higher after preoperative chemotherapy and exhibited less change in expression in deceased patients compared to patients surviving more than 5 years (both p = 0.001). Ezrin expression at biopsy was significantly associated with both histopathological aggressiveness (p |
| تدمد: | 1423-0380 1010-4283 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2378c853c39b784d50de0dbfb93dca27Test https://doi.org/10.1007/s13277-016-5091-1Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2378c853c39b784d50de0dbfb93dca27 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230380 10104283 |
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