التفاصيل البيبلوغرافية
| العنوان: |
Prognostic Factors and Metastatic Patterns in Primary Myxoid/Round-Cell Liposarcoma. |
| المؤلفون: |
Haniball, J., Sumathi, V. P., Kindblom, L.-G., Abudu, A., Carter, S. R., Tillman, R. M., Jeys, L., Spooner, D., Peake, D., Grimer, R. J. |
| المصدر: |
Sarcoma; 2011, p1-10, 10p, 1 Color Photograph, 4 Charts, 3 Graphs |
| مصطلحات موضوعية: |
CANCER relapse, CHI-squared test, COMBINED modality therapy, CONFIDENCE intervals, METASTASIS, LIPOSARCOMA, RADIOTHERAPY, RESEARCH funding, SURVIVAL analysis (Biometry), T-test (Statistics), TUMOR classification, U-statistics, PROPORTIONAL hazards models, RETROSPECTIVE studies, DATA analysis software, DESCRIPTIVE statistics, PROGNOSIS, THERAPEUTICS |
| مستخلص: |
Background. This study aimed to investigate prognostic factors for patients with myxoid/round-cell liposarcoma (MRCLS), in particular the significance of the round cell component, and to identify metastatic patterns as well as possibly suggest a suitable strategy for followup. Methods. Clinical, morphologic, and follow-up data from 160 patients with MRCLS was reviewed and statistically analysed. Results. Of 130 tumours with the round cell component evaluated, 61 had no round cell component, 27 had <5% round cell component, and 42 had >5%. All patients underwent surgical excision, 15 requiring amputation. 107 patients received adjuvant radiotherapy. Local recurrence occurred in 19 patients (12%), predominantly in patients with marginal or intralesional margins and a round cell component. Overall disease specific survival was 75% at 5 years and 56% at 10 years and was related to the proportion of round cell component. Of 52 patients who developed metastases, 38 (73%) had purely extrapulmonary metastases. We could not identify any factors predicting the site of metastases developing. Conclusions. The occurrence of any round cell component is the most important adverse prognostic factor for patients with MRCLS; patients with >5% round cell component are at higher risk of local recurrence, metastasis and tumour-related death and should be considered for adjuvant radiotherapy and possibly chemotherapy. The best method of monitoring extrapulmonary metastases remains to be established. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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