دورية أكاديمية
Bevacizumab for newly diagnosed ovarian cancers: Best candidates among high-risk disease patients (icon-7)
| العنوان: | Bevacizumab for newly diagnosed ovarian cancers: Best candidates among high-risk disease patients (icon-7) |
|---|---|
| المؤلفون: | Colomban, O, Tod, M, Peron, J, Perren, TJ, Leary, A, Cook, AD, Sajous, C, Freyer, G, You, B |
| المصدر: | JNCI Cancer Spectrum , 4 (3) , Article pkaa026. (2021) |
| سنة النشر: | 2021 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | chemotherapy regimen, ca-125 antigen, phase 3 clinical trials, kinetics, neoplasms, ovarian cancer, bevacizumab, elimination rate constant, progression-free survival, datasets |
| الوصف: | Bevacizumab is approved as a maintenance treatment in first-line setting in advanced-stage III-IV ovarian cancers, because GOG-0218 and ICON-7 phase III trials demonstrated progression-free survival benefits. However, only the subgroup of patients with high-risk diseases (stage IV, and incompletely resected stage III) derived an overall survival (OS) gain in the ICON-7 trial (4.8 months). The modeled CA-125 elimination rate constant K (KELIM) parameter, based on the longitudinal CA- 125 kinetics during the first 100 days of chemotherapy, is a potential indicator of the tumor primary chemo-sensitivity. In the ICON-7 trial dataset, the OS of patients within the low- and high-risk disease groups was assessed according to treatment arms and KELIM. Among the patients with high-risk diseases, those with favorable standardized KELIM of at least 1.0 (n=214, 46.7%) had no survival benefit from bevacizumab, whereas those with unfavorable KELIM less than 1.0 (n=244, 53.2%) derived the highest OS benefit (absolute difference = 9.1 months, 2-sided log-rank P=.10; Cox hazard ratio = 0.78, 95% confidence interval = 0.58 to 1.04, 2-sided P=.09). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10123745/1/pkaa026.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10123745Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10123745/1/pkaa026.pdfTest https://discovery.ucl.ac.uk/id/eprint/10123745Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.ECBDBF8E |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |