دورية أكاديمية
Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria
| العنوان: | Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria |
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| المؤلفون: | Jansen, Marc H., van Zanten, Sophie E. Veldhuijzen, Aliaga, Esther Sanchez, Heymans, Martijn W., Warmuth-Metz, Monika, Hargrave, Darren, van der Hoeven, Erica J., Gidding, Corrie E., de Bont, Eveline S., Eshghi, Omid S., Reddingius, Roel, Peeters, Cache M., Schouten-van Meeteren, Antoinette Y. N., Gooskens, Rob H. J., Granzen, Bernd, Paardekooper, Gabriel M., Janssens, Geert O., Noske, David P., Barkhof, Frederik, Kramm, Christof M., Vandertop, W. Peter, Kaspers, Gertjan J., van Vuurden, Dennis G. |
| المصدر: | Jansen , M H , van Zanten , S E V , Aliaga , E S , Heymans , M W , Warmuth-Metz , M , Hargrave , D , van der Hoeven , E J , Gidding , C E , de Bont , E S , Eshghi , O S , Reddingius , R , Peeters , C M , Schouten-van Meeteren , A Y N , Gooskens , R H J , Granzen , B , Paardekooper , G M , Janssens , G O , Noske , D P , Barkhof , F , Kramm .... |
| سنة النشر: | 2015 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | brainstem neoplasms, glioma, magnetic resonance imaging, pons, prognosis, BRAIN-STEM GLIOMA, CHILDHOOD, TUMORS, CHEMOTHERAPY, TRIALS |
| الوصف: | Background. Although diffuse intrinsic pontine glioma (DIPG) carries the worst prognosis of all pediatric brain tumors, studies on prognostic factors in DIPG are sparse. To control for confounding variables in DIPG studies, which generally include relatively small patient numbers, a survival prediction tool is needed. Methods. A multicenter retrospective cohort study was performed in the Netherlands, the UK, and Germany with central review of clinical data and MRI scans of children with DIPG. Cox proportional hazards with backward regression was used to select prognostic variables (P<.05) to predict the accumulated 12-month risk of death. These predictors were transformed into a practical risk score. The model's performance was validated by bootstrapping techniques. Results. A total of 316 patients were included. The median overall survival was 10 months. Multivariate Cox analysis yielded 5 prognostic variables of which the coefficients were included in the risk score. Age Conclusions. We developed a DIPG survival prediction tool that can be used to predict the outcome of patients and for stratification in trials. Validation of the model is needed in a prospective cohort. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/48f63060-97cd-4b66-bdfb-d677d62ec1c6Test |
| DOI: | 10.1093/neuonc/nou104 |
| الإتاحة: | https://doi.org/10.1093/neuonc/nou104Test https://hdl.handle.net/11370/48f63060-97cd-4b66-bdfb-d677d62ec1c6Test https://research.rug.nl/en/publications/48f63060-97cd-4b66-bdfb-d677d62ec1c6Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.D0803F5F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/neuonc/nou104 |
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