التفاصيل البيبلوغرافية
| العنوان: |
Persistent lymph nodes after curative chemoradiotherapy for head and neck cancer: imaging predictors of response for decision-making. |
| المؤلفون: |
Páez-Carpio, Alfredo1 (AUTHOR) paez@clinic.cat, Medrano-Martorell, Santiago1 (AUTHOR), Berenguer, Joan1 (AUTHOR), Muxí, Africa2 (AUTHOR), Vilaseca, Isabel3 (AUTHOR), Valduvieco, Izaskun4 (AUTHOR), Castillo, Paola5 (AUTHOR), Baste, Neus6 (AUTHOR), Avilés-Jurado, F. Xavier3 (AUTHOR), Grau, Juan José6 (AUTHOR), Oleaga, Laura1 (AUTHOR) |
| المصدر: |
European Archives of Oto-Rhino-Laryngology. Mar2023, Vol. 280 Issue 3, p1369-1379. 11p. |
| مصطلحات موضوعية: |
*LYMPH nodes, *HEAD & neck cancer, *HUMAN papillomavirus, *CHEMORADIOTHERAPY, *SQUAMOUS cell carcinoma |
| مستخلص: |
Purpose: To identify response predictors in patients with head and neck squamous cell carcinoma (N + HNSCC) and persistent lymph nodes after curative chemoradiotherapy treatment (CCRT). Materials and methods: Consecutive patients with N + HNSCC treated with CCRT and persistent lymph nodes at first follow-up between 2015 and 2021 were identified and analyzed. Complete response was defined as the absence of lymph node metastatic involvement in patients with salvage lymphadenectomy or the absence of progression after 1 year of successive follow-ups. Tumour type and location, staging, and human papillomavirus (HPV) status were considered for analysis. The number and size of lymph nodes, type, shape, enhancement and margins on diagnostic and follow-up CT were also analyzed. Results: The cohort included 46 patients with 134 pathological lymph nodes. Logistic regression models showed the following variables to be significant: performance of salvage lymphadenectomy (OR 0.094, [CI 95% 0.004–0.61], p = 0.037); the type of lymphadenopathy on diagnostic CE-CT (solid vs. cystic) (N1: OR = 4.11, [CI 95% 1.11–17.93], p = 0.042 and N3: OR 6.42, [CI 95% 1.2–42.56], p = 0.036); the change of shape (round to oval) on the follow-up CE-CT (OR 9.76, [CI 95% 1.79–8.57], p = 0.016) and the time in days between CCRT and the first follow-up CE-CT (OR 1.06, [CI 95% 1.004–1.13], p = 0.048). Conclusions: In our experience, the presence of solid lymph nodes on pre-treatment CT and the change in shape from round to oval on post-treatment CT are predictors of response to treatment in patients with N + HNSCC persistent lymph nodes after CCRT. Increasing the temporal interval between treatment and follow-up CT should be considered to avoid unnecessary nodal dissections. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
