Serum Inflammatory Markers and Preeclampsia in Type 1 Diabetes
| العنوان: | Serum Inflammatory Markers and Preeclampsia in Type 1 Diabetes |
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| المؤلفون: | Mei Du, Michael Centola, Timothy J. Lyons, Satish K. Garg, Samar M. Hammad, Arpita Basu, Mingyuan Wu, Christopher E. Aston, Kristian F. Hanssen, Dongxu Fu, Alicia J. Jenkins, James A. Scardo |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030204 cardiovascular system & hematology, Gastroenterology, Preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Longitudinal Studies, Prospective Studies, Endothelial dysfunction, Prospective cohort study, Pathophysiology/Complications, Original Research, Advanced and Specialized Nursing, Type 1 diabetes, 030219 obstetrics & reproductive medicine, biology, business.industry, C-reactive protein, medicine.disease, 3. Good health, Chemokine CXCL10, Interleukin 1 Receptor Antagonist Protein, Endocrinology, C-Reactive Protein, Diabetes Mellitus, Type 1, biology.protein, Female, Age of onset, business, E-Selectin |
| الوصف: | OBJECTIVE Inflammation and endothelial dysfunction have been associated with the immunobiology of preeclampsia (PE), a significant cause of adverse pregnancy outcomes. The prevalence of PE is elevated several fold in the presence of maternal type 1 diabetes mellitus (T1DM). Although cross-sectional studies of pregnancies among women without diabetes have shown altered inflammatory markers in the presence of PE, longitudinal studies of diabetic women are lacking. In maternal serum samples, we examined the temporal associations of markers of inflammation with the subsequent development of PE in women with T1DM. RESEARCH DESIGN AND METHODS We conducted longitudinal analyses of serum C-reactive protein (CRP), adhesion molecules, and cytokines during the first (mean ± SD, 12.2 ± 1.9 weeks), second (21.6 ± 1.5 weeks), and third (31.5 ± 1.7 weeks) trimesters of pregnancy (visits 1–3, respectively). All study visits took place before the onset of PE. Covariates were BMI, HbA1c, age of onset, duration of diabetes, and mean arterial pressure. RESULTS In women with T1DM who developed PE versus those who remained normotensive, CRP tended to be higher at visits 1 (P = 0.07) and 2 (P = 0.06) and was significantly higher at visit 3 (P < 0.05); soluble E-selectin and interferon-γ–inducible protein-10 (IP-10) were significantly higher at visit 3; interleukin-1 receptor antagonist (IL-1ra) and eotaxin were higher and lower, respectively, at visit 2 (all P < 0.05). These conclusions persisted following adjustment for covariates. CONCLUSIONS In pregnant women with T1DM, elevated CRP, soluble E-selectin, IL-1ra, and IP-10 and lower eotaxin were associated with subsequent PE. The role of inflammatory factors as markers and potential mechanisms of the high prevalence of PE in T1DM merits further investigation. |
| اللغة: | English |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072f345d20ad922ef0e96f5a4b11110fTest http://europepmc.org/articles/PMC3687330Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....072f345d20ad922ef0e96f5a4b11110f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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