دورية أكاديمية
Phenotypic expressions of CCR5-Delta 32/Delta 32 homozygosity
| العنوان: | Phenotypic expressions of CCR5-Delta 32/Delta 32 homozygosity |
|---|---|
| المؤلفون: | Nguyen, GT, Carrington, M, Beeler, JA, Dean, M, Aledort, LM, Blatt, PM, Cohen, AR, DiMichele, D, Eyster, ME, Kessler, CM, Konkle, B, Leissinger, C, Luban, N, O'Brien, SJ, Goedert, JJ, O'Brien, TR |
| المصدر: | Nguyen , GT , Carrington , M , Beeler , JA , Dean , M , Aledort , LM , Blatt , PM , Cohen , AR , DiMichele , D , Eyster , ME , Kessler , CM , Konkle , B , Leissinger , C , Luban , N , O'Brien , SJ , Goedert , JJ & O'Brien , TR 1999 , ' Phenotypic expressions of CCR5-Delta 32/Delta 32 homozygosity ' , Journal of acquired immune deficiency syndromes , vol. 22 , no. 1 , pp. 75-82 . ; ISSN:1077-9450 |
| سنة النشر: | 1999 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | AIDS, CCR5, chemokine, receptors, epidemiology, genetics, HIV-1, hemophilia, hepatitis C virus, hypertension, lymphocytes, therapy, HUMAN IMMUNODEFICIENCY VIRUS, HIV-1 INFECTION, CHEMOKINE RECEPTORS, DISEASE PROGRESSION, DELETION ALLELE, RESISTANCE, GENE, CORECEPTOR |
| الوصف: | Objective: As blockade of CC-chemokine receptor 5 (CCR5) has been proposed as therapy for HIV-1, we examined whether the CCR5-Delta 32/Delta 32 homozygous genotype has phenotypic expressions other than those related to HIV-1. Design: Study subjects were white homosexual men or men with hemophilia who were not infected with HIV-1. In this study, 15 CCR5-Delta 32/Delta 32 homozygotes were compared with 201 CCR5 wild-type (+/+) subjects for a wide range of clinical conditions and laboratory assay results ascertained during prospective cohort studies and routine clinical care. CCR5-Delta 32 genotype was determined by polymerase chain reaction, followed by single-stranded conformational polymorphism analysis. Results: Hypertension and conditions attributable to hemophilia were the only diagnoses frequently found in clinical records of CCR5-Delta 32/Delta 32 study subjects. Based on blood pressure measurement and treatment history, CCR5-Delta 32/Delta 32 homozygotes had a 2.8-fold higher prevalence of hypertension than age-matched CCR5-+/+ study subjects (95% confidence interval [CI], 1.2-6.4; p = .01); none of the homozygotes had severe hypertension. Hematologic measures were generally similar across the genotypes, but total lymphocyte counts were similar to 20% higher in CCR5-Delta 32/Delta 32 study subjects than in CCR5-+/+ study subjects (p <.05). Among patients with hemophilia who were infected with hepatitis C virus (HCV), mean alanine aminotransferase levels were 117% higher among CCR5-Delta 32/Delta 32 homozygotes (p <.05), but serum HCV levels did not differ by CCR5-Delta 32 genotype. CCR5-Delta 32/Delta 32 homozygous study subjects had a lower prevalence of antibodies to measles virus than those with other genotypes, but this association was not confirmed in a group of blood donors. The prevalence of antibodies to nine other common viruses, HBV, and HCV was not related to CCR5 genotype. Conclusions: CCR5-Delta 32/Delta 32 homozygotes are generally similar to wild-type persons. Confirmatory ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| الإتاحة: | http://hdl.handle.net/11370/8508394d-d1a9-4338-a5bc-c0ec9a7919ddTest https://research.rug.nl/en/publications/phenotypic-expressions-of-ccr5delta-32delta-32-homozygosityTest(8508394d-d1a9-4338-a5bc-c0ec9a7919dd).html |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.6FE1A4B3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |