Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer
| العنوان: | Selective phytochemicals targeting pancreatic stellate cells as new anti-fibrotic agents for chronic pancreatitis and pancreatic cancer |
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| المؤلفون: | Wei Mee Loh, Rhanye Mac Guad, Maw Shin Sim, Subash C. B. Gopinath, Puvanesswaray Ramakrishnan, Yuan Seng Wu, Ismail Muhamad Fareez, Srinivasa Reddy Bonam |
| المصدر: | Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 399-413 (2020) Acta Pharmaceutica Sinica. B |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Drug, Curcumin, Emodin, media_common.quotation_subject, Phytochemicals, Review, Pharmacology, Resveratrol, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Resverastrol, Pancreatic cancer, Medicine, General Pharmacology, Toxicology and Pharmaceutics, 030304 developmental biology, media_common, 0303 health sciences, Pancreatic stellate cells, business.industry, lcsh:RM1-950, Rhein, medicine.disease, Metformin, Anti-fibrotic, lcsh:Therapeutics. Pharmacology, chemistry, Green tea catechin, 030220 oncology & carcinogenesis, Hepatic stellate cell, Pancreatitis, business, Chronic pancreatitis, medicine.drug |
| الوصف: | Activated pancreatic stellate cells (PSCs) have been widely accepted as a key precursor of excessive pancreatic fibrosis, which is a crucial hallmark of chronic pancreatitis (CP) and its formidable associated disease, pancreatic cancer (PC). Hence, anti-fibrotic therapy has been identified as a novel therapeutic strategy for treating CP and PC by targeting PSCs. Most of the anti-fibrotic agents have been limited to phase I/II clinical trials involving vitamin analogs, which are abundant in medicinal plants and have proved to be promising for clinical application. The use of phytomedicines, as new anti-fibrotic agents, has been applied to a variety of complementary and alternative approaches. The aim of this review was to present a focused update on the selective new potential anti-fibrotic agents, including curcumin, resveratrol, rhein, emodin, green tea catechin derivatives, metformin, eruberin A, and ellagic acid, in combating PSC in CP and PC models. It aimed to describe the mechanism(s) of the phytochemicals used, either alone or in combination, and the associated molecular targets. Most of them were tested in PC models with similar mechanism of actions, and curcumin was tested intensively. Future research may explore the issues of bioavailability, drug design, and nano-formulation, in order to achieve successful clinical outcomes with promising activity and tolerability. Graphical abstract Quiescent PSCs are converted to their activated form by the actions of lymphocyte, macrophage and/or via autocrine stimulation. Our selective phytochemicals treat chronic pancreatitis and pancreatic cancer by targeting PSCs via the suppression of the same signaling pathways, including ERK1/2, P38 MAPK, SHH signaling and PI3K/Akt.Image 1 |
| اللغة: | English |
| تدمد: | 2211-3835 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cc8f545dab3dc347260adafa522c48Test http://www.sciencedirect.com/science/article/pii/S2211383519310767Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....49cc8f545dab3dc347260adafa522c48 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22113835 |
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