المؤلفون: Woo Youp Kim, Su Young Been, Gilson Khang, Cheol Ui Song, Hun Hwi Cho, Jeong Eun Song, Alessio Bucciarelli, Jeong Min Choi, Joo Hee Choi

المصدر: ACS Applied Bio Materials. 4:1900-1911

مصطلحات موضوعية: Scaffold, Bone Regeneration, Composite number, Biomedical Engineering, Biocompatible Materials, Bone tissue engineering, Biomaterials, chemistry.chemical_compound, Materials Testing, Animals, Particle Size, Bone regeneration, Rest (music), Tissue Engineering, Tissue Scaffolds, Polysaccharides, Bacterial, Biochemistry (medical), Hydrogels, Mesenchymal Stem Cells, General Chemistry, Skeleton (computer programming), Gellan gum, Rats, chemistry, Rabbits, Demineralized bone, Biomedical engineering

الوصف: Bone is the rigid tissue that constitutes the skeleton. The material for bone regeneration has to provide the mechanical stability by maintaining the mechanical loads both in the rest conditions and during the body movements. Bone is dynamic tissue constantly reshaped by the action of cells (osteoblasts and osteoclasts). This activity is normally enough to heal bone injuries; however, in several conditions, when bone is subjected to fatal damages, self-renewal is difficult, if not even impossible, and a medical treatment is required. The transplantation of a biomaterial is one of the common surgical procedures to overcome critical injuries. In this study, we exploited the effect of the use of different sources of demineralized bone powder (DBP) in combination with gellan gum (GG) to form a GG-DBP hydrogel scaffold with the purpose of regenerating the bone tissue. DBP was extracted from the femurs of two typologies of

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49c4d4e28c6b2b48f002e4113bb8b5fTest
https://doi.org/10.1021/acsabm.0c01549Test

المؤلفون: Mazhar Iqbal, Saif Ullah, Sana Aslam, Julie Pelletier, Jamshed Iqbal, Sadia Sultan, Matloob Ahmad, Jean Sévigny, Afshan Kanwal

المصدر: ChemistrySelect. 5:14399-14407

مصطلحات موضوعية: Nucleotide pyrophosphatase, Benzimidazole, chemistry.chemical_compound, chemistry, Stereochemistry, Biological activity, General Chemistry, Benzothiazine, Skeleton (computer programming), Phosphodiesterase inhibition

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b0a4a6a96a05652d478b00afe5efa0acTest
https://doi.org/10.1002/slct.202003479Test

المؤلفون: Girdhar Pal Singh, Pathan Sultan Ismail, Repale Anil Vithal

المصدر: Letters in Organic Chemistry. 17:743-748

مصطلحات موضوعية: Active ingredient, In situ, chemistry.chemical_compound, chemistry, 010405 organic chemistry, Organic Chemistry, Organic chemistry, Pyrazole, 010402 general chemistry, 01 natural sciences, Biochemistry, Skeleton (computer programming), 0104 chemical sciences

الوصف: Celecoxib containing pyrazole derivatives were synthesized by path aldol condensation of substituted ketone with trifluoroethyl acetate subsequently by cyclization of the formed chalcones with 4-methanesulfonylphenylhydrazine. Here, a one-pot synthesis of celecoxib and substituted analogues have been reported which are nonsteroidal anti-inflammatory drugs for their cyclooxygenase (COX) inhibition, anti-inflammatory activity and ulcerogenic liability. In order to intermediate work-up, a continuous one-pot synthesis has been developed, performing the entire reaction sequence that results in a shorter time with good yield.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5712ef8593b2aa0859666e8ab81cdfc9Test
https://doi.org/10.2174/1570178617666200207110526Test

المؤلفون: Hyungi Kim, Min Chul Shin, Eunha Kim

المصدر: Bulletin of the Korean Chemical Society. 42:95-98

مصطلحات موضوعية: Core (optical fiber), chemistry.chemical_compound, Chemistry, Polymer chemistry, Indolizine, General Chemistry, Fluorescence, Fluoride, Skeleton (computer programming)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9213c9973a38097c5eb830d68b1f20c3Test
https://doi.org/10.1002/bkcs.12134Test

المؤلفون: Sabry H. H. Younes, Mohamed T. El-wassimy, Mohamed-Elamir F. Hegazy, Tarik A. Mohamed, Abdelaaty A. Shahat, Mahmoud Moustafa, Abdelsamed I. Elshamy, Hazem A. Albadry

المصدر: Journal of the Chinese Chemical Society. 68:338-342

مصطلحات موضوعية: chemistry.chemical_compound, Chemistry, Stereochemistry, Artemisia sieberi, General Chemistry, Sesquiterpene, Skeleton (computer programming), Tetrahydrofuran

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::dd907ffca58de9e07fe538335253a4b5Test
https://doi.org/10.1002/jccs.202000198Test

المؤلفون: Leeann D. Louis, Shoshana Yakar, Mitchell B. Schaffler, Godze Yildirim, Manisha Dixit, John J. Kopchick, Andrzej Bartke, Silvana Duran-Ortiz, Sher Bahadur Poudel

المصدر: Aging Cell

مصطلحات موضوعية: Male, Senescence, Aging, medicine.medical_specialty, Medullary cavity, Matrix (biology), Biology, Spectrum Analysis, Raman, bone, Raman microspectroscopy, Mice, chemistry.chemical_compound, Internal medicine, medicine, Animals, Original Paper, micro‐CT, Cell Biology, Original Papers, Skeleton (computer programming), Sexual dimorphism, Bone Diseases, Metabolic, Endocrinology, medicine.anatomical_structure, chemistry, sexual dimorphism, Growth Hormone, Osteocyte, Body Composition, Sclerostin, Female, Bone marrow

الوصف: Somatopause refers to the gradual declines in growth hormone (GH) and insulin‐like growth factor‐1 throughout aging. To define how induced somatopause affects skeletal integrity, we used an inducible GH receptor knockout (iGHRKO) mouse model. Somatopause, induced globally at 6 months of age, resulted in significantly more slender bones in both male and female iGHRKO mice. In males, induced somatopause was associated with progressive expansion of the marrow cavity leading to significant thinning of the cortices, which compromised bone strength. We report progressive declines in osteocyte lacunar number, and increases in lacunar volume, in iGHRKO males, and reductions in lacunar number accompanied by ~20% loss of overall canalicular connectivity in iGHRKO females by 30 months of age. Induced somatopause did not affect mineral/matrix ratio assessed by Raman microspectroscopy. We found significant increases in bone marrow adiposity and high levels of sclerostin, a negative regulator of bone formation in iGHRKO mice. Surprisingly, however, despite compromised bone morphology, osteocyte senescence was reduced in the iGHRKO mice. In this study, we avoided the confounded effects of constitutive deficiency in the GH/IGF‐1 axis on the skeleton during growth, and specifically dissected its effects on the aging skeleton. We show here, for the first time, that induced somatopause compromises bone morphology and the bone marrow environment.
Induced somatopause during aging causes a drop in GH/IGF‐1 signaling, inhibits radial bone expansion and associates with increased bone marrow adiposity. At the bone tissue level, induced somatopause leads to progressive declines in osteocyte lacunar density and connectivity.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25a3d93ce66a007e37b4ed8f8c8554aTest
https://doi.org/10.1111/acel.13505Test

المؤلفون: Carolina Afonso de Lima, Débora Barbosa Vendramini-Costa, Fernanda Francetto Juliano, Mary Ann Foglio, Darlon I. Bernardi, Giovanna B. Longato, Severino Matias de Alencar, Juliana R. Gubiani, Ronaldo A. Pilli, João E. de Carvalho, Afif F. Monteiro, Cláudio R. Nogueira, Thais Petrochelli Banzato, Antonio G. Ferreira, Roberto G. S. Berlinck

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: Magnetic Resonance Spectroscopy, PRÓPOLIS, Ovarian cancer cell line, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, 01 natural sciences, Propolis, Analytical Chemistry, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Humans, Cytotoxic T cell, Doxorubicin, Ovarian Neoplasms, Antibiotics, Antineoplastic, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Skeleton (computer programming), Phenotype, 0104 chemical sciences, Multiple drug resistance, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, Drug Resistance, Neoplasm, Molecular Medicine, Chromane, Female, Drug Screening Assays, Antitumor, Brazil, medicine.drug

الوصف: Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A-D (1-4), with a 3-{3-[(2-phenylbenzofuran-3-yl)methyl]phenyl}chromane skeleton; propolonones A-C (5-7), with a 3-[3-(3-benzylbenzofuran-2-yl)phenyl]chromane skeleton; and propolol A (8), with a 6-(3-benzylbenzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B (2) and propolonone A (5) display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a905057c23fc7d36b905545568df4caaTest
https://doi.org/10.1021/acs.jnatprod.9b01136Test

المؤلفون: Zhijie Yang, David Hui, Man Jiang, Xiangzhou Hu, Jihua Gou, Kang Senxian, Zuowan Zhou, Jing He

المصدر: Nanotechnology Reviews, Vol 9, Iss 1, Pp 345-353 (2020)

مصطلحات موضوعية: Technology, Materials science, Physical and theoretical chemistry, QD450-801, Energy Engineering and Power Technology, Medicine (miscellaneous), 3D printing, 02 engineering and technology, TP1-1185, 010402 general chemistry, 01 natural sciences, Nanomaterials, Biomaterials, chemistry.chemical_compound, Cellulose, solution, hydrogel skeleton, Materials processing, business.industry, 3d printing, Process Chemistry and Technology, Chemical technology, Industrial chemistry, 021001 nanoscience & nanotechnology, Skeleton (computer programming), cellulose, 0104 chemical sciences, Surfaces, Coatings and Films, chemistry, Chemical engineering, Extrusion, 0210 nano-technology, business, Biotechnology

الوصف: Cellulose is the most abundant natural polymer on earth, which has obtained increasing interest in the field of functional materials development for its renewable, high mechanical performance and environmental benign. In this study, the traditional processing method (wet spinning and film production) of cellulose-based materials was applied by using cellulose solution for 3D printing, which can directly build complex 3D patterns. Herein, a natural cellulose is dissolved in an effective mixed aqueous solution of dimethyl sulfoxide (DMSO) and tetrabutylammonium hydroxide (TBAH). The cellulose solution extrusion was controlled by a modified fused deposition modeling (FDM) 3D printer. During the controlled extrusion 3D printing process, the viscous cellulose solution will gelifies and further solidifies into a predetermined 3D pattern at room temperature in air. Subsequently, a cellulose hydrogel skeleton was obtained, when the 3D pattern was solvent-exchanged with deionized water. Finally, the mechanical and swelling performance of the cellulose hydrogel scaffold was improved by a cross-linking agent treatment method. With treatment of the 3D printed scaffolds in 0.8 wt% cross-linking agent solution, the obtained cellulose hydrogel could absorb 28 g/g water, and the compression strength was 96 kPa. This work provided an efficient way to prepare natural cellulose hydrogel by 3D printing under room temperature.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4366d1007a5a12bcbe1259a45743f3acTest
https://doaj.org/article/f8abeb151c344589ab996eef6b1462afTest

المؤلفون: Zhinan Mei, Jing Xu, Rui Qin, Yu Chen, Haida Teng, Hong Liu, Guangzhong Yang, Qing Xue

المصدر: The Journal of Organic Chemistry. 85:6620-6625

مصطلحات موضوعية: chemistry.chemical_compound, Garcibracteatone, chemistry, 010405 organic chemistry, Dodecane, Stereochemistry, Organic Chemistry, 010402 general chemistry, Garcinia bracteata, 01 natural sciences, Skeleton (computer programming), 0104 chemical sciences, Nitric oxide

الوصف: Two novel polycyclic polyprenylated acylphloroglucinols (PPAPs), garcibractinones A (1) and B (2), as well as three known analogues doitunggarcinones A-B (3-4) and garcibracteatone (5) were isolated from Garcinia bracteata fruits. Their structures were elucidated by comprehensive spectroscopic methods and single crystal X-ray diffraction. Compounds 1 and 2 possess an unprecedented caged tricyclo-[4.4.1.11,4] dodecane skeleton, and their biosynthetic pathways are also proposed. Compounds 1-2 were tested for their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::09a9ffa2909875b180408cdaf9f43a45Test
https://doi.org/10.1021/acs.joc.0c00637Test

المؤلفون: Xiao-Nian Li, Qin-Shi Zhao, Li-Yan Peng, Xing-De Wu

المصدر: The Journal of Organic Chemistry. 85:6803-6807

مصطلحات موضوعية: Lycopodium, biology, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Huperzia serrata, Hexadecane, 010402 general chemistry, Oxime, Ring (chemistry), biology.organism_classification, 01 natural sciences, Skeleton (computer programming), 0104 chemical sciences, chemistry.chemical_compound, chemistry

الوصف: Huperserratines A (1) and B (2), two Lycopodium alkaloids with an unprecedented 5-aza-bicyclo[10.4.0]hexadecane skeleton and an oxime function, were isolated from Huperzia serrata. Their structures including absolute configurations were determined by extensive NMR spectroscopic and X-ray diffraction analysis. Compounds 1 and 2 were the first examples of macrocyclic Lycopodium alkaloids with an aza-12-membered ring. A plausible biogenetic pathway of these compounds was also proposed. Compound 1 exhibited moderate anti-HIV-1 activity with an EC50 of 52.91 μg/mL and a therapy index greater than 3.78.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9b9fef3f631934bad8a32fee15631708Test
https://doi.org/10.1021/acs.joc.0c00623Test