يعرض 1 - 10 نتائج من 5,027 نتيجة بحث عن '"RADIOLIGAND assay"', وقت الاستعلام: 0.72s تنقيح النتائج
  1. 1
    Studies on the affinity of 6-[(n-(cyclo)aminoalkyl)oxy]-4H-chromen-4-ones for sigma 1/2 receptors

    المؤلفون: Winnie Deuther-Conrad, Isabel Iriepa, Michael Gütschow, Francisco López-Muñoz, Maria Angeles Martinez-Grau, Daniel Diez-Iriepa, José Marco-Contelles

    المصدر: Digital.CSIC. Repositorio Institucional del CSIC
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    RSC Medicinal Chemistry 12(2021)6, 1000-1004

    مصطلحات موضوعية: Stereochemistry, receptor binding, Pharmaceutical Science, Inhibitory postsynaptic potential, 01 natural sciences, Biochemistry, radioligand assay, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Receptor, Butyrylcholinesterase, 030304 developmental biology, Pharmacology, 0303 health sciences, chromenones, 010405 organic chemistry, Chemistry, Organic Chemistry, Antagonist, sigma 1/2 receptors, multitarget small molecules, Acetylcholinesterase, Small molecule, 0104 chemical sciences, ADME, docking, Molecular Medicine, Monoamine oxidase B, Selectivity

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c9ddbbaab5176df0c44aca1aede0a3Test
    https://doi.org/10.1039/d1md00105aTest


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  2. 2
    [3H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H4 Receptors

    المؤلفون: Günther Bernhardt, Takeaki Ozawa, Timo Littmann, Edith Bartole, Miho Tanaka, Armin Buschauer

    المصدر: Journal of Medicinal Chemistry. 62:8338-8356

    مصطلحات موضوعية: 0303 health sciences, Reporter gene, Chemistry, Ligand, Stereochemistry, 01 natural sciences, Radioligand Assay, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Diaminopyrimidine, Drug Discovery, Radioligand, Molecular Medicine, Structure–activity relationship, Receptor, Histamine, 030304 developmental biology

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::38cf3fa3dc7cfe67e062fa66221bab18Test
    https://doi.org/10.1021/acs.jmedchem.9b01342Test


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  3. 3
    Widespread Changes in Positive Allosteric Modulation of the Muscarinic M1 Receptor in Some Participants With Schizophrenia

    المؤلفون: Andrea Gogos, Geoffrey Pavey, Shaun Hopper, Brian Dean

    المصدر: International Journal of Neuropsychopharmacology

    مصطلحات موضوعية: Male, Allosteric modulator, hippocampus, striatum, Allosteric regulation, Hippocampus, Quinolones, musccarinic M1 receptor, Tritium, Regular Research Articles, Radioligand Assay, chemistry.chemical_compound, Allosteric Regulation, mental disorders, medicine, Humans, Pharmacology (medical), Cerebral Cortex, Pharmacology, business.industry, Dentate gyrus, Receptor, Muscarinic M1, Muscarinic acetylcholine receptor M1, Middle Aged, N-Methylscopolamine, medicine.disease, Corpus Striatum, schizophrenia, Psychiatry and Mental health, medicine.anatomical_structure, positive allosteric modulation, chemistry, Cerebral cortex, Schizophrenia, Case-Control Studies, Autoradiography, Female, business, Xanomeline, Neuroscience, Protein Binding

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19f7d8d3a17931a1a122c536c895d4dTest
    https://doi.org/10.1093/ijnp/pyz045Test


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  4. 4
    A radioligand receptor binding assay for measuring of insulin secreted by MIN6 cells after stimulation with glucose, arginine, ornithine, dopamine, and serotonin

    المؤلفون: Jiří Jiráček, Lenka Žáková, Aleš Marek, Seiya Asai, Irena Selicharová

    المصدر: Analytical and bioanalytical chemistry. 413(17)

    مصطلحات موضوعية: Ornithine, Serotonin, Arginine, medicine.medical_treatment, Dopamine, Radioimmunoassay, 02 engineering and technology, 01 natural sciences, Biochemistry, Analytical Chemistry, Cell Line, chemistry.chemical_compound, Islets of Langerhans, Mice, Radioligand Assay, Insulin-Secreting Cells, Insulin Secretion, Radioligand, medicine, Animals, Humans, Insulin, Rats, Wistar, biology, Chemistry, Ligand binding assay, 010401 analytical chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Rats, Insulin receptor, Glucose, biology.protein, Secretagogue, 0210 nano-technology

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06dcebfa0e1c3f4e53e7c0510df9ebd7Test
    https://pubmed.ncbi.nlm.nih.gov/34050775Test


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  5. 5
    C-2-Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors

    المؤلفون: Hans-Georg Breitinger, Yasmine M Mandour, Anders A. Jensen, Ahmed El Nady, Darius P. Zlotos, Ulrike Breitinger, Liza S Botros, Carine M Abdelmalek, Carmen Villmann, Ulrike Holzgrabe, Maha M. Banoub, Christoph A. Sotriffer

    المصدر: Journal of natural products. 84(2)

    مصطلحات موضوعية: Receptor complex, Stereochemistry, Pharmaceutical Science, Ligands, 01 natural sciences, Analytical Chemistry, chemistry.chemical_compound, Radioligand Assay, Receptors, Glycine, Drug Discovery, Homomeric, Humans, Binding site, Glycine receptor, Ion channel, Pharmacology, Binding Sites, 010405 organic chemistry, Chemistry, Organic Chemistry, Strychnine, 0104 chemical sciences, Protein Structure, Tertiary, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Complementary and alternative medicine, Docking (molecular), Molecular Medicine, Pharmacophore

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda231034e194187da1742a80cc1e716Test
    https://pubmed.ncbi.nlm.nih.gov/33596384Test


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  6. 6
    Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a 'Tail Switching' Strategy on a Piperazinyl Azetidine Skeleton

    المؤلفون: Yiding Zhang, Zhen Chen, Ran Cheng, Tuo Shao, Yihan Shao, Qingzhen Yu, Jun-An Ma, Kuan Hu, Xiaoyun Deng, Akiko Hatori, Steven H. Liang, Lee Josephson, Hualong Fu, Kenneth Dahl, Neil Vasdev, Michael A. Schafroth, Masayuki Fujinaga, Lin Xie, Christopher J. Fowler, Shuyin Gu, Thomas Lee Collier, Lu Wang, Benjamin F. Cravatt, Jian Rong, Daisuke Ogasawara, Tomoteru Yamasaki, Bao Liang, Yuancheng Gou, Ming-Rong Zhang, Xiaofei Zhang, Katsushi Kumata, Genwei Zhang, Wakana Mori, Jingjin Chen

    المصدر: Journal of Medicinal Chemistry. 62:3336-3353

    مصطلحات موضوعية: Azetidine, Proof of Concept Study, 01 natural sciences, Piperazines, Article, Rats, Sprague-Dawley, Mice, Radioligand Assay, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Tissue Distribution, Enzyme Inhibitors, Binding selectivity, 030304 developmental biology, Mice, Knockout, 0303 health sciences, Dose-Response Relationship, Drug, medicine.diagnostic_test, Neurodegeneration, Serine hydrolase, medicine.disease, Endocannabinoid system, Monoacylglycerol Lipases, Rats, 0104 chemical sciences, Molecular Docking Simulation, Monoacylglycerol lipase, 010404 medicinal & biomolecular chemistry, chemistry, Positron emission tomography, Drug Design, Positron-Emission Tomography, Biophysics, Azetidines, Molecular Medicine, Radiopharmaceuticals

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5214207fa88d5f4a116c261d6c7b1c2Test
    https://doi.org/10.1021/acs.jmedchem.8b01778Test


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  7. 7
    Monitoring of the dopamine D2 receptor agonists hordenine and N-methyltyramine during the brewing process and in commercial beer samples

    المؤلفون: Harald Hübner, Thomas Sommer, Monika Pischetsrieder, Gelena Dlugash, Peter Gmeiner

    المصدر: Food Chemistry. 276:745-753

    مصطلحات موضوعية: Spectrometry, Mass, Electrospray Ionization, Phenethylamine, Tyramine, CHO Cells, 01 natural sciences, Analytical Chemistry, Radioligand Assay, chemistry.chemical_compound, Cricetulus, 0404 agricultural biotechnology, Mashing, Tandem Mass Spectrometry, Dopamine receptor D2, Animals, Humans, Chromatography, High Pressure Liquid, N-Methyltyramine, Chromatography, Receptors, Dopamine D2, business.industry, Alkaloid, Hordenine, 010401 analytical chemistry, Beer, food and beverages, Hordeum, 04 agricultural and veterinary sciences, General Medicine, 040401 food science, 0104 chemical sciences, chemistry, Dopamine Agonists, Fermentation, Brewing, business, Food Analysis, Food Science

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081f03d7a3bb99f5d692a486fab3297dTest
    https://doi.org/10.1016/j.foodchem.2018.10.067Test


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  8. 8
    Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model

    المؤلفون: Vicent Casadó, Sergi Ferré, Antoni Cortés, Estefanía Moreno, Verònica Casadó-Anguera, Enric I. Canela, Josefa Mallol

    المصدر: Pharmacological Research. 139:337-347

    مصطلحات موضوعية: 0301 basic medicine, Dimer, Allosteric regulation, Cooperativity, Binding, Competitive, Article, Receptors, G-Protein-Coupled, Protein–protein interaction, Radioligand Assay, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Radioligand, Animals, Binding site, G protein-coupled receptor, Pharmacology, Sheep, Chemistry, Cell Membrane, Brain, Dissociation constant, 030104 developmental biology, 030220 oncology & carcinogenesis, Biophysics, Protein Multimerization

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ebe8397bb6a625106f24f2329759d2Test
    https://doi.org/10.1016/j.phrs.2018.11.032Test


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  9. 9
    Characterization of binding, functional activity, and contractile responses of the selective 5-HT1F receptor agonist lasmiditan

    المؤلفون: Peter B. Senese, Eric Zanelli, Kristian Agmund Haanes, Joseph Kovalchin, Ad J.J.C. Bogers, Antoinette MaassenVanDenBrink, Carlos M. Villalón, Alejandro Labastida-Ramírez, Antoon J. van den Bogaerdt, Kirk W. Johnson, Laurent Meeus, Eloísa Rubio-Beltrán, Michael R Gralinski, A.H. Jan Danser

    المساهمون: Internal Medicine, Cardiothoracic Surgery

    المصدر: British Journal of Pharmacology
    British Journal of Pharmacology, 176(24), 4681-4695. Wiley-Blackwell

    مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, medicine.drug_class, Pyridines, Triptans, CHO Cells, Pharmacology, In Vitro Techniques, Binding, Competitive, 03 medical and health sciences, chemistry.chemical_compound, Radioligand Assay, 0302 clinical medicine, Cricetulus, Dogs, Piperidines, In vivo, medicine, Potency, Animals, Humans, Receptor, Dose-Response Relationship, Drug, business.industry, Sumatriptan, Cell Membrane, 5-HT1F receptor, Research Papers, Coronary Vessels, Meningeal Arteries, Lasmiditan, Serotonin Receptor Agonists, 030104 developmental biology, chemistry, Vasoconstriction, Receptors, Serotonin, Benzamides, cardiovascular system, Female, business, 030217 neurology & neurosurgery, medicine.drug, Research Paper, Muscle Contraction, Protein Binding

    وصف الملف: application/pdf

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45db3763c959ce78f9ceaf2dbf6f5759Test
    https://doi.org/10.1111/bph.14832Test


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  10. 10
    From Darkness to Light: Pretargeted Radionuclide Imaging Driven by Tetrazine Bioorthogonal Chemistry

    المؤلفون: Guohua Shen, Baoyi Ge, Zhenhua Liu, Anren Kuang, Haoxing Wu

    المصدر: Current Topics in Medicinal Chemistry. 18:1515-1519

    مصطلحات موضوعية: Radioisotopes, Antibodies, Monoclonal, Tetrazoles, General Medicine, Ligands, Combinatorial chemistry, Theranostic Nanomedicine, Kinetics, Radioligand Assay, Cyclooctanes, Tetrazine, chemistry.chemical_compound, chemistry, Neoplasms, Drug Discovery, Humans, Radionuclide imaging, Radiopharmaceuticals, Bioorthogonal chemistry, Radionuclide Imaging

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e70df4953e856b8da3f88ff733e8e1Test
    https://doi.org/10.2174/156802661818181119142326Test


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