نتائج البحث - "Marcus C. S. Lee"

1

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage

المؤلفون: Prapon Wilairat, Maria G. Gomez-Lorenzo, Thanat Chookajorn, Kesinee Chotivanich, Krittikorn Kümpornsin, Laura M. Sanz, Cristina de Cozar, Marcus C. S. Lee, Namfon Kotanan, Duangkamon Loesbanluechai, Nicholas J. White, Francisco-Javier Gamo

المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 186-190 (2021)
International Journal for Parasitology: Drugs and Drug Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d3e099e19347efd4515052b596b009Test
http://www.sciencedirect.com/science/article/pii/S2211320721000488Test

2

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature communications, vol 11, iss 1

مصطلحات موضوعية: 0301 basic medicine, ved/biology.organism_classification_rank.species, Protozoan Proteins, General Physics and Astronomy, Synthetic lethality, Endoplasmic Reticulum, Plasmodium, Mass Spectrometry, chemistry.chemical_compound, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, lcsh:Science, Chromatography, High Pressure Liquid, Chromatography, Multidisciplinary, Secretory Pathway, biology, Brefeldin A, Cell biology, Infectious Diseases, 5.1 Pharmaceuticals, High Pressure Liquid, HIV/AIDS, Development of treatments and therapeutic interventions, medicine.symptom, Infection, Science, 030106 microbiology, Saccharomyces cerevisiae, Plasmodium falciparum, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Antimalarials, Inhibitory Concentration 50, Rare Diseases, Target identification, parasitic diseases, medicine, Secretion, Model organism, Gene, Secretory pathway, ved/biology, Endoplasmic reticulum, Autophagy, General Chemistry, biology.organism_classification, Malaria, Vector-Borne Diseases, Good Health and Well Being, 030104 developmental biology, chemistry, Mechanism of action, Pyrazoles, lcsh:Q

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b18290350407667761814a3f37b90a3Test
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69Test

3

Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

المصدر: Cell Chemical Biology. 29:191-201.e8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e3028ee2d6c74bf0739d4ebecac7ebTest
https://doi.org/10.1016/j.chembiol.2021.07.010Test

4

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

المصدر: Cell Chem Biol

مصطلحات موضوعية: Hydrolases, Clinical Biochemistry, Plasmodium falciparum, Drug Resistance, Protozoan Proteins, Drug resistance, Biology, 01 natural sciences, Biochemistry, Article, Serine, chemistry.chemical_compound, Antimalarials, parasitic diseases, Drug Discovery, medicine, Animals, Humans, Parasites, Malaria, Falciparum, Diet, Fat-Restricted, Molecular Biology, Pharmacology, Orlistat, Biological Products, Natural product, 010405 organic chemistry, Serine hydrolase, Lipid metabolism, biology.organism_classification, Bridged Bicyclo Compounds, Heterocyclic, Lipid Metabolism, Monoacylglycerol Lipases, Malaria, 0104 chemical sciences, Monoacylglycerol lipase, Mechanism of action, chemistry, Molecular Medicine, Click Chemistry, medicine.symptom

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd1de8040b695e68d20b488036ea2d8Test
https://pubmed.ncbi.nlm.nih.gov/32084335Test

5

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery

المؤلفون: Manuel Llinás, David A. Fidock, Eva S. Istvan, Elizabeth A. Winzeler, Sabine Ottilie, James M. Murithi, Marcus C. S. Lee, Kelly Chibale, Daniel E. Goldberg, Edward Owen, Manu Vanaerschot

المصدر: Cell chemical biology. 27(2)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986390d82f3fd8a60506373de3bb3953Test
https://pubmed.ncbi.nlm.nih.gov/32084336Test

6

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

المؤلفون: Megan R. Ansbro, Krittikorn Kümpornsin, Cristina de Cozar, Francisco-Javier Gamo, Kesinee Chotivanich, Thanat Chookajorn, Nicholas J. White, Prapon Wilairat, Laura M. Sanz, Theerarat Kochakarn, Namfon Kotanan, Duangkamon Loesbanluechai, Marcus C. S. Lee

المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss, Pp 16-22 (2019)
International Journal for Parasitology: Drugs and Drug Resistance

مصطلحات موضوعية: 0301 basic medicine, 030231 tropical medicine, Population, Plasmodium falciparum, Plasmepsin, Drug Resistance, Gene Dosage, Protozoan Proteins, Artesunate, Microbial Sensitivity Tests, Pharmacology, Biology, Article, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, chemistry.chemical_compound, Antimalarials, Inhibitory Concentration 50, 0302 clinical medicine, Plasmepsin II, Chloroquine, Piperaquine, parasitic diseases, medicine, Aspartic Acid Endopeptidases, Pharmacology (medical), lcsh:RC109-216, Artemisinin, education, education.field_of_study, biology.organism_classification, Malaria, 030104 developmental biology, Infectious Diseases, chemistry, Quinolines, Parasitology, Cambodia, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d17c8d5806e04364f6db892fb8a7b6Test
https://ora.ox.ac.uk/objects/uuid:8b0786fe-9a95-41e1-b755-e01b79b2efb9Test

7

CRISPR-Cas9-modifiedpfmdr1protectsPlasmodium falciparumasexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs

المؤلفون: Amélie Le Bihan, David A. Fidock, Victoria C. Corey, Pietro Alano, Giulia Siciliano, Selina Bopp, Martine Clozel, Rachel G. Kasdin, Sergio Wittlin, Elizabeth A. Winzeler, Lucia Bertuccini, Mariana Justino de Almeida, Caroline L. Ng, Marcus C. S. Lee

المصدر: Molecular Microbiology. 101:381-393

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e95e7af3f97a2378e235c43d765da3d5Test
https://doi.org/10.1111/mmi.13397Test

8

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

المؤلفون: Erika Sasaki, David A. Fidock, María Linares, Maria G. Gomez-Lorenzo, Pedro A. Moura, Gregory LaMonte, Eva S. Istvan, Olga Tanaseichuk, Dionicio Siegel, Elizabeth A. Winzeler, Virginia Franco, Olivia Fuchs, Aslı Akidil, Erika L. Flannery, Nina F. Gnädig, Manuel Llinás, Yingyao Zhou, Tomoyo Sakata-Kato, Daniel E. Goldberg, Ignacio Arriaga, Pamela Magistrado, Roy Williams, Heather J. Painter, Sang W. Kim, Paul Willis, Dyann F. Wirth, Sabine Ottilie, James M. Murithi, Annie N. Cowell, Lawrence T. Wang, Edward Owen, Olivia Coburn-Flynn, Victoria C. Corey, Matthew Abraham, Manu Vanaerschot, Francisco-Javier Gamo, Selina Bopp, Yang Zhong, Amanda K. Lukens, Marcus C. S. Lee, Purva Gupta, Christine H. Teng, Sophie H. Adjalley, Christin Reimer

المصدر: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Science (New York, N.Y.)
Science (New York, N.Y.), vol 359, iss 6372

مصطلحات موضوعية: 0301 basic medicine, Nonsynonymous substitution, Genes, Protozoan, Druggability, Drug Resistance, Genome, Activation, Metabolic, chemistry.chemical_compound, 2.2 Factors relating to the physical environment, Aetiology, Multidisciplinary, Drug discovery, Drug Resistance, Multiple, 3. Good health, Infectious Diseases, Protozoan, Infection, Multiple, DNA Copy Number Variations, General Science & Technology, Plasmodium falciparum, Activation, Computational biology, Biology, Article, Vaccine Related, 03 medical and health sciences, Antimalarials, Rare Diseases, Genetic, Biodefense, Genetics, Chemogenomics, Metabolomics, Selection, Genetic, Selection, Gene, Alleles, Prevention, Human Genome, biology.organism_classification, Malaria, Resistome, Vector-Borne Diseases, Emerging Infectious Diseases, Orphan Drug, Good Health and Well Being, 030104 developmental biology, Genes, chemistry, Mutation, Metabolic, Antimicrobial Resistance, Directed Molecular Evolution, Genome, Protozoan, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e8cf3f4266035d283abb3c97fc622bTest
https://repositoriosaludmadrid.es/handle/20.500.12530/38180Test

9

Mapping the malaria parasite drug-able genome using in vitro evolution and chemogenomics

مصطلحات موضوعية: Genetics, 0303 health sciences, 030306 microbiology, Drug discovery, Genomics, Plasmodium falciparum, Drug resistance, Biology, biology.organism_classification, Genome, 3. Good health, Resistome, Multiple drug resistance, 03 medical and health sciences, chemistry.chemical_compound, chemistry, parasitic diseases, Chemogenomics, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2a260fb1258addb091c29bd48b0b26Test

10

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

المؤلفون: Adele M. Lehane, Anupam Pradhan, David A. Fidock, Dennis E. Kyle, Gloria Holbrook, Amy Matheny, Martina Sigal, Anang A. Shelat, David Waterson, Iñigo Angulo-Barturen, Kathleen O’Loughlin, Jian Liu, Laura M. Sanz, Philip D. Stein, Daniel H. Ebert, Kiaran Kirk, Hongshen Ma, Marcus C. S. Lee, Jon C. Mirsalis, W. Armand Guiguemde, Xiaoyan Deng, Greg Fedewa, Ane Rodríguez-Alejandre, María Belén Jiménez-Díaz, María G. Gómez, Angela K. Carrillo, Mariana Justino de Almeida, Yandira G. Salinas, Vicky M. Avery, David M. Shackleford, Sandra Duffy, Marie-Eve Myrand-Lapierre, Gregory M. Miller, María Santos Martínez, Adelaide S. M. Dennis, Charles C. Kim, R. Kiplin Guy, Julie Clark, Jeremy A. Horst, Aaron N. Endsley, Joseph L. DeRisi, Zheng Wang, Spencer Knapp, Fangyi Zhu, David M. Floyd, Santiago Ferrer, Jonathon Diep, Francisco-Javier Gamo, Susan A. Charman, Natalie J. Spillman

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 50

مصطلحات موضوعية: Models, Molecular, Plasmodium, Erythrocytes, Drug Resistance, Drug resistance, Pharmacology, Corrections, chemistry.chemical_compound, Models, Heterocyclic Compounds, Drug Discovery, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Cellular Senescence, PfATP4, Multidisciplinary, Molecular Structure, Drug discovery, Flow Cytometry, Cell biology, Infectious Diseases, PNAS Plus, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Infection, Cell aging, Intracellular, Phenotypic screening, malaria, Calcium-Transporting ATPases, Biology, Heterocyclic Compounds, 4 or More Rings, drug discovery, Antimalarials, Rare Diseases, In vivo, Prevention, Molecular, Plasmodium falciparum, 4 or More Rings, biology.organism_classification, Isoquinolines, Cipargamin, High-Throughput Screening Assays, Malaria, Vector-Borne Diseases, Orphan Drug, Good Health and Well Being, chemistry

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd38753b4b27787a1d271647ca26a4f8Test
https://europepmc.org/articles/PMC4273362Test/

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